Wu, Jin Luo, Yiting Shen, Yan Hu, Yuyao Zhu, Fangyuan Wu, Jiaqian Liu, Yingchao
Published in
Drug Design, Development and Therapy
Background Traditional Chinese medicine (TCM) has the advantage of multi-component and multi-target, which becomes a hot spot in the treatment of numerous diseases. Shaoyao decoction (SYD) is a TCM prescription, which is mainly used to treat damp-heat dysentery clinically, with small side effects and low cost. However, its mechanism remains elusive...
Ren, Qingjuan Chen, Shuchun Chen, Xing Niu, Shu Yue, Lin Pan, Xiaoyu Li, Zelin Chen, Xiaoyi
Published in
Drug Design, Development and Therapy
Purpose This study aimed to investigate the effect of Semaglutide on skeletal muscle and its metabolomics. Methods A total of 18 male C57BL/6 mice were randomly divided into normal control (NC) group, high-fat diet (HFD) group and HFD+Semaglutide group, and were given standard diet, HFD diet, HFD diet plus Semaglutide, respectively. The body weight...
Wang, Lini Wang, Yiting Ma, Yumei Mu, Xiaoxiao Zhang, Zhen Wang, Huan Zheng, Ziyu Nie, Huang
Published in
Drug Design, Development and Therapy
Purpose This retrospective study evaluated the efficacy, opioid consumption, and safety profile of two patient-controlled intravenous analgesia (PCIA) regimens (sufentanil combined with nalbuphine vs sufentanil alone) after cesarean section (CS). Patients and Methods Parturients (n = 1808) received sufentanil combined with nalbuphine (SN group) or ...
Zhang, Min Lv, Yao Liu, Haokui
Published in
Drug Design, Development and Therapy
Objective To investigate the efficacy of cyclophosphamide combined with prednisone in membranous nephropathy (MN) patients with different cytochrome P450 (CYP) 2B6 gene polymorphisms and explore the factors influencing the efficacy. Methods We performed a prospective and interventional study including 153 outpatients diagnosed with membranous nephr...
Ding, Qin Huang, Shuqi Sun, Zexu Chen, Kaifeng Li, Xin Pei, Qi
Published in
Drug Design, Development and Therapy
Posaconazole is often used for the prophylaxis and treatment of invasive fungal infections (IFI). However, intra- and inter-individual differences and drug interactions affect the efficacy and safety of posaconazole. Precision dosing of posaconazole based on the population pharmacokinetic (PopPK) model may assist in making significant clinical deci...
Schmidt, Christin Schnierle, Barbara S
Published in
Drug Design, Development and Therapy
Chikungunya virus (CHIKV) is an alphavirus that has spread globally in the last twenty years. Although mortality is rather low, infection can result in debilitating arthralgia that can persist for years. Unfortunately, no treatments or preventive vaccines are currently licensed against CHIKV infections. However, a large range of promising preclinic...
Chen, Yingna Lu, Jieya Xie, Zhihao Tang, Jialing Lian, Xuejiao Li, Xiuwen
Published in
Drug Design, Development and Therapy
Background Tumor microenvironment has attracted more and more attention in oncology. Alisol B23 acetate (AB23A) inhibits the proliferation of tumor cells including non-small cell lung cancer (NSCLC) cells. However, whether AB23A plays a role in the tumor microenvironment of NSCLC still remains obscure. Methods After THP-1 cells were polarized to M0...
Spagnuolo, Vincenzo Voarino, Marta Tonelli, Marco Galli, Laura Poli, Andrea Bruzzesi, Elena Racca, Sara Clementi, Nicola Oltolini, Chiara Tresoldi, Moreno
...
Published in
Drug Design, Development and Therapy
Background Evidence regarding the impact of remdesivir (RDV) on SARS-CoV-2 viral clearance (VC) is scarce. The aim of this study was to compare VC timing in hospitalized COVID-19 patients who did or did not receive RDV. Methods This was a matched-cohort study of patients hospitalized with pneumonia, a SARS-CoV-2-positive nasopharyngeal swab (NPS) a...
Braun, Jürgen Kiltz, Uta Baraliakos, Xenofon
Published in
Drug Design, Development and Therapy
Although the pathogenesis of spondyloarthritis (SpA) has still not been elucidated our options to treat SpA have definitely improved in the last decades. There are two main types of SpA: (i) axial spondyloarthritis (axSpA), also covering the classical ankylosing spondylitis (AS) which is largely equivalent to radiographic (r)-axSpA but different fr...
Wu, Hao Wang, Yu Zhang, Bing Li, Yao-lei Ren, Zhi-xin Huang, Jing-jian Zhang, Zhi-qi Lin, Zhi-jian Zhang, Xiao-meng
Published in
Drug Design, Development and Therapy
Smilax glabra Roxb . (SGB) is a medicinal plant widely distributed in 17 countries worldwide. It is the primary raw material of the world-famous and best-selling functional food and beneficial tea. SGB was first recorded in Ben Cao Jing Ji Zhu of the Southern and Northern Dynasties (420–589 AD) and was reported for nutritional and medicinal propert...
