Luo, Xiaobin Zhao, Bin Chen, Baoxia Chen, Hongyu Han, Tao Bsoul, Najeeb Bassam Najeeb Yan, Hede
Published in
Drug Design, Development and Therapy
Background The application of random pattern skin flaps is limited in plastic surgery reconstruction due to necrosis. Trans-cinnamaldehyde has antibacterial, anticancer, and antioxidant properties. In this study, we aimed to investigate the effect of trans-cinnamaldehyde on skin flap survival and its possible mechanism regarding nitric oxide. Mater...
Liu, Shijiang Peng, Peipei Hu, Youli Liu, Cunming Cao, Xiaofei Yang, Chun Gao, Mei
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Drug Design, Development and Therapy
Purpose The present study aimed to determine the effectiveness of intravenous dexmedetomidine of different concentrations and to evaluate its maternal and neonatal safety when combined with butorphanol in parturients undergoing cesarean section. Patients and Methods A total of 114 parturients between 24 and 43 years of age, with singleton pregnancy...
Gomha, Sobhi M Abdelhady, Hyam A Hassain, Doaa Z H Abdelmonsef, Aboubakr H El-Naggar, Mohamed Elaasser, Mahmoud M Mahmoud, Huda K
Published in
Drug Design, Development and Therapy
Introduction Hybrid drug design has developed as a prime method for the development of novel anticancer therapies that can theoretically solve much of the pharmacokinetic disadvantages of traditional anticancer drugs. Thus a number of studies have indicated that thiazole-thiophene hybrids and their bis derivatives have important anticancer activity...
Yang, Eunsol Yoo, Hyounggyoon Jang, In-Jin Yu, Kyung-Sang Lee, SeungHwan
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Drug Design, Development and Therapy
Purpose A fixed-dose combination (FDC) of gemigliptin/rosuvastatin 50/20 mg as a monolayer tablet has been used to treat patients with both type 2 diabetes mellitus and dyslipidemia. To improve the stability of the FDC, a new FDC formulation as a bilayer tablet was developed. This study aimed to compare the pharmacokinetics (PKs) and pharmacodynami...
Sun, Yang Long, Di
Published in
Drug Design, Development and Therapy
Background The present work is an effort to develop a novel locally injection LVTT-loaded PLGA microspheres (LVTT-PLGA-MS) on the treatment of rabbits with femoral head necrosis (FHN). Methods LVTT-loaded PLGA microspheres (LVTT-PLGA MS) were prepared by an emulsion-solvent evaporation method. The physicochemical properties of LVTT-PLGA-MS were inv...
Lin, Wenxiang Zhao, Libei Tan, Qian Lin, Ding
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Drug Design, Development and Therapy
Purpose Efficacy of norvancomycin (NVCM) through continuous topical ocular instillation drug delivery (CTOIDD) system for treating severe acute bacterial keratitis infection with Staphylococcus aureus was investigated. Methods Rabbits with bacterial keratitis were treated using CTOIDD with NVCM (n=13), topical NVCM eye drops (n=11), and CTOIDD with...
Sun, Wenrui Hu, Binchuan Zhang, Xiaoshan Wang, Yuzhen Xiang, Zheng Lin, Guanyang
Published in
Drug Design, Development and Therapy
Background Polymyxin B, as the final treatment against multidrug-resistant Gram-negative bacilli, is widely used in clinical practice. However, little is known about the nephrotoxicity of polymyxin B. The purpose of this study was to elucidate the relationship between polymyxin B nephrotoxicity and daily administration frequency. Methods Sprague–Da...
Liu, Yi-Fu Fu, Sheng-Qiang Yan, Yu-Chang Gong, Bin-Bin Xie, Wen-Jie Yang, Xiao-Rong Sun, Ting Ma, Ming
Published in
Drug Design, Development and Therapy
Gonadotropin-releasing hormone (GnRH) receptor agonists are still the most commonly used androgen deprivation treatment (ADT) drugs for prostate cancer in clinical practice. Currently, the GnRH receptor antagonists used for endocrine therapy for prostate cancer primarily include degarelix and relugolix (TAK-385). The former is administered by subcu...
Guo, Ling Jiang, Bei Li, Dengren Xiao, Xiaoyan
Published in
Drug Design, Development and Therapy
Background Diabetic Nephropathy remains a major cause of morbidity and mortality in patients suffering from renal dysfunction. This study accessed the nephroprotective role of Adropinin against streptozotocin (STZ) induced diabetic nephropathy in rats and scrutinizes the possible mechanism of action. Methods STZ (45 mg/kg) dose was used for inducin...
Xie, Panpan Xue, Wei Qi, Wenyuan Li, Yang Yang, Lei Yang, Zhaojun Shi, Aixin
Published in
Drug Design, Development and Therapy
Background Ibuprofenamine hydrochloride spray is novel transdermal nonsteroidal anti-inflammatory drugs (NSAIDs), under clinical development for the treatment of Rheumatoid Arthritis and Osteoarthritis as a novel transdermal drug. Methods A single and multiple ascending dose study investigated the safety, tolerability and pharmacokinetics of ibupro...
