Wang, Meng-Jie Zhao, Yu-Hang Fan, Chen Wang, Ying-Jie Wang, Xin-Qi Qiu, Xiang-Jun Shen, Rui-Le
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Drug Design, Development and Therapy
Background Upadacitinib, a novel selective Janus kinase 1 (JAK1) inhibitor, has been recently approved by the US FDA for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantitative analysis of upadacitinib i...
Yao, Jijin Wang, Ying Lin, Yujing Yang, Yingying Wan, Jingjing Gong, Xiaohua Zhang, Fanwei Zhang, Wangjian Marks, Tia Wang, Siyang
...
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Drug Design, Development and Therapy
Introduction To evaluate the role of maximal standardized uptake values (SUVmax) and total lesion glycolysis (TLG) from serial 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for early prediction of neoadjuvant chemotherapy (NAC) response in locoregionally advanced nasopharyngeal carcinoma (LANPC). Methods A t...
Voute, Marion Morel, Véronique Pickering, Gisèle
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Drug Design, Development and Therapy
Topical lidocaine is widely used in current practice for a variety of pain conditions. This literature review shows that its limited absorption and relative lack of systemic adverse events are an attractive analgesic option for a number of vulnerable patients. Topical lidocaine has been approved by health authorities for the treatment of post-herpe...
Wang, Chunyan Chen, Zhengyun Zhao, Xianlei Lin, Cuicui Hong, Shenghui Lou, Yuhan Shi, Xiaomeng Zhao, Mengdan Yang, Xiaohang Guan, Min-Xin
...
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Drug Design, Development and Therapy
Introduction Endometriosis (EMs) is associated with severe chronic pelvic pain and infertility and the development of improved EMs treatment options is an ongoing focus. In this study, we investigated the effects of resveratrol on EMs and analyzed transcriptional changes in the lesions of model rats before and after resveratrol treatment. Methods W...
Chen, Wenwen He, Lin Zhong, Lian Sun, Jiayi Zhang, Lilin Wei, Daneng Wu, Chunjie
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Drug Design, Development and Therapy
Introduction Huangtu decoction (HTD) has been widely used in the treatment of gastrointestinal bleeding, ulcerative colitis (UC) and gastrointestinal tumors in China, but its active compounds and mechanism are still not clear yet. The present research aimed to identify the active compounds and mechanism of HTD for the treatment of UC. Methods First...
Tang, Xiaomeng Yang, Meng Gu, Yongwei Jiang, Liangdi Du, Yue Liu, Jiyong
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Drug Design, Development and Therapy
Zhang, Yun Wang, Jie Liu, Yong-Mei Chen, Yin-Ying Yang, Xiao-Chen Duan, Lian
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Drug Design, Development and Therapy
Background and Purpose Two Chinese herbal medicines Huang Qi (HQ, Astragalus mongholicus ) and Dan Shen (DS, Salvia miltiorrhiza ) are often combined to treat coronary heart disease (CHD). The purpose of this study was to identify the underlying synergistic effects and mechanisms of HQ and DS against CHD. Methods The active components and targets o...
Suharyani, Ine Fouad Abdelwahab Mohammed, Ahmed Muchtaridi, Muchtaridi Wathoni, Nasrul Abdassah, Marline
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Drug Design, Development and Therapy
Li, Huan Zhai, Bingtao Sun, Jing Fan, Yu Zou, Junbo Cheng, Jiangxue Zhang, Xiaofei Shi, Yajun Guo, Dongyan
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Drug Design, Development and Therapy
Aljarba, Nada H Ali, Huma Alkahtani, Saad
Published in
Drug Design, Development and Therapy
Introduction Synergy is defined as an interaction of some substances that cooperate to give rise to the combined effect greater than the sum of their individual effects. It is a natural strategy that has evolved by nature to more efficacy with low cost. Methods This study is designed to evaluate the chemopreventive effect of a combined drug sample ...
