Fu, Liya Zhu, Wanlong Tian, Dongmei Tang, Yong Ye, Yun Wei, Qiming Zhang, Chengbin Qiu, Wenqiao Qin, Dalian Yang, Xuping
...
Published in
Drug design, development and therapy
Anoectochilus roxburghii (Wall.) Lindl. polysaccharides (ARPs) have been reported to exhibit multiple pharmacological activities including anti-inflammatory and anti-hyperglycemia. This study aims to investigate the effect of ARPs on cognitive dysfunction induced by high fat diet (HFD). Six-week-old male mice were treated with ARPs by dietary suppl...
Gao, Jia Yang, Sifu Xie, Guanqun Pan, Jieli Zhu, Feiye
Published in
Drug Design, Development and Therapy
Purpose This study was designed to evaluate the pharmacological mechanisms of Aloin against gastric cancer (GC) via network pharmacology analysis combined with experimental verification. Methods Using network pharmacology methods, the potential targets of Aloin and targets related to GC were screened from public databases. The protein–protein inter...
Napolitano, Maria D’Amico, Ferdinando Ragaini, Elisa Peyrin-Biroulet, Laurent Danese, Silvio
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Drug Design, Development and Therapy
Upadacitinib is a selective small molecule that inhibits Janus kinase (JAK) type 1. This molecule is administrated orally and is currently approved for the treatment of rheumatoid arthritis, atopic dermatitis, and psoriatic arthritis. Upadacitinib has been approved by the United States Food and Drug Administration for the induction and maintenance ...
Zhou, Can-Can Huang, Fang Zhang, Jing-Ming Zhuang, Yu-Gang
Published in
Drug Design, Development and Therapy
Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage regimens remain controversial. The purpose of this article was to help guide tigecycline dosing in different patient subpopulations through comparing the published population pharmacokinetic models of tigecycline, as well as summarizing and determining the p...
Gao, Yahao Jiang, Di Wang, Changshui An, Gang Zhu, Li Cui, Changmeng
Published in
Drug Design, Development and Therapy
Purpose Sodium valproate (VPA) is the most widely used broad-spectrum antiepileptic first-line drug in clinical practice and is effective against various types of epilepsy. However, VPA can induce severe cardiotoxicity, nephrotoxicity, hepatotoxicity, and neurotoxicity, which limits its use. Metabolomic studies of VPA-induced toxicity have focused ...
Majeed, Chaudry Nasir Ma, Christopher D Xiao, Ted Rudnick, Sean Bonkovsky, Herbert L
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Drug Design, Development and Therapy
Small interfering ribonucleic acids [siRNAs] are short ribonucleic acid (RNA) fragments cleaved from double-stranded RNA molecules that target and bind to specific sequences on messenger RNA (mRNA), leading to their destruction. Therefore, the siRNA down-regulates the formation of selected mRNAs and their protein products. Givosiran is one such siR...
Hjartarson, Helgi Thor Nathorst-Böös, Kristofer Sejersen, Thomas
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Drug Design, Development and Therapy
SMA (5q SMA) is an autosomal recessive neuromuscular disease with an estimated incidence of approximately 1 in 11,000 live births, characterized by progressive degeneration and loss of α-motor neurons in the spinal cord and brain stem, resulting in progressive muscle weakness. The disease spectrum is wide, from a serious congenital to a mild adult-...
Shu, Wan Wang, Ziwei Zhao, Rong Shi, Rui Zhang, Jun Zhang, Wei Wang, Hongbo
Published in
Drug Design, Development and Therapy
Background Endometrial cancer (EC) is one of the most common gynecological malignancies, especially in postmenopausal women. Echinacoside (ECH) is a major natural bioactive ingredient derived from Cistanches Herba and Echinacea that has a variety of pharmacological effects. However, the efficacy and the mechanism of ECH against EC have not been elu...
Mekkawy, Aml I Fathy, M Mohamed, Hebatallah B
Published in
Drug Design, Development and Therapy
Liu, Jingjing Fan, Guoqing Tao, Ningning Feng, Feifei Meng, Chao Sun, Tieying
Published in
Drug Design, Development and Therapy
Purpose Idiopathic pulmonary fibrosis is a chronic and irreversible fibrotic interstitial pneumonia of unknown etiology and therapeutic strategies are limited. Emerging evidence suggests that the continuous activation of the central nucleotide-binding oligomerization-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome...
