Xu, Zhewei Li, Zhiyue
Published in
Drug Design, Development and Therapy
Background This study aimed to explore the effect of Apelin-13 in protecting rats against spinal cord ischemia reperfusion injury (SCIR), as well as the related molecular mechanisms. Methods One week prior to the experiment, experimental Sprague–Dawley rats were injected with Apelin-13 and the autophagy activator rapamycin through the tail vein onc...
Ge, Jianyun Huang, Yulin Zhang, Yi Liu, Lin Gu, Tianyu Liu, Xu Yao, Lei Cai, Mengmeng Sun, Jiafeng Song, Jie
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Published in
Drug Design, Development and Therapy
Objective To elucidate the neuroprotective function of metformin in suppressing propofol-induced apoptosis of HT-22 cells. Methods HT-22 cells were treated with 0, 10 or 100 μmol/L propofol, followed by determination of their proliferative ability. Subsequently, changes in proliferation and apoptosis of propofol-treated HT-22 cells induced with met...
Li, Shumin Li, Yaqian Xu, Hong Wei, Zhongqiu Yang, Yi Jin, Fuyu Zhang, Min Wang, Chen Song, Wenxiong Huo, Jingchen
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Published in
Drug Design, Development and Therapy
Purpose The role of angiotensin-converting enzyme 2 (ACE2) in silicosis remains unknown, although previous studies have suggested that ACE2 may be beneficial. We, therefore, investigated the effect of ACE2 on silicosis, particularly with regard to its role in regulating the epithelial-mesenchymal transition (EMT) induced by silica, with the aim to ...
Yu, Xiao-Xia Ge, Ke-Li Liu, Ning Zhang, Jin-Yu Xue, Mei-Lan Ge, Yin-Lin
Published in
Drug Design, Development and Therapy
Background The efficacy of traditional therapeutic methods for liver cancer is unsatisfying because of the poor targeting, and inefficient drug delivery system. A recent study has proven that aptamers, developed through cell-SELEX, could specifically recognize cancer cells and show great potential in the development of a delivery system for antican...
Rouamba, Toussaint Sondo, Paul Derra, Karim Nakanabo-Diallo, Seydou Bihoun, Biebo Rouamba, Eli Tarnagda, Zekiba Kazienga, Adama Valea, Innocent Sorgho, Hermann
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Published in
Drug Design, Development and Therapy
Background and purpose Resource-limited countries face challenges in setting up effective pharmacovigilance systems. This study aimed to monitor the occurrence of adverse events (AEs) after the use of artemisinin-based combination therapies (ACTs), identify potential drivers of reporting suspected adverse drug reactions (ADRs) and monitor AEs among...
Zhu, Jiayi Huang, Yanling Zhang, Jiquan Feng, Yi Shen, Lan
Published in
Drug Design, Development and Therapy
Background “Unification of medicines and excipients” is the special principle which means fatty oil with pharmacodynamic activity derived from traditional Chinese medicine are taken as liquid lipids in perparation for dual-drug delivery, which improve the treatment effect and reduce unnecessary excipients. Purpose The aim of this study was to prep...
Wu, Qingbin Yuan, Xiaochen Li, Bingwei Han, Ruiqin Zhang, Honggang Xiu, Ruijuan
Published in
Drug Design, Development and Therapy
Objective To investigate the effect of salvianolic acid A (SA) on the permeability of blood–brain barrier (BBB) and brain microvascular pericyte apoptosis in spontaneously hypertensive rats (SHR). Methods Evans Blue was used to determine the BBB permeability in control rats and SHR. Western blotting was used to evaluate the expression levels of rel...
Yu, Linyuan Gong, Lihong Wang, Cheng Hu, Naihua Tang, Yunqiu Zheng, Li Dai, Xuyang Li, Yunxia
Published in
Drug Design, Development and Therapy
Purpose Nonalcoholic fatty liver disease (NAFLD) has become a predictor of death in many diseases. This study was carried out to investigate the therapeutic effect of Radix Polygoni Multiflori Preparata (RPMP) and its main component emodin on egg yolk powder-induced NAFLD in zebrafish. Further investigation was performed to explore whether emodin w...
Ghoneim, Amira M Mansour, Suzan M
Published in
Drug Design, Development and Therapy
Background and Objectives Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials on patients with special diseases. In this study, simulations were carried out to validate the pharmacokinetic parameters of clozapine and sildenafil using Simcyp® simulator in young male ad...
Liao, Yuan Tan, Rui-zhi Li, Jian-chun Liu, Tong-tong Zhong, Xia Yan, Ying Yang, Jie-ke Lin, Xiao Fan, Jun-ming Wang, Li
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Published in
Drug Design, Development and Therapy
Purpose Chronic kidney disease (CKD) is a global nephrotic syndrome characterized by chronic inflammation, oxidative stress and fibrosis in the kidney. Isoliquiritigenin (ISL), a flavonoid from licorice, has historically been reported to inhibit innate immune responses to inflammation and fibrosis in vivo. However, the effect of ISL on CKD progress...
