Published in Digestive Diseases and Sciences
IntroductionLimitations in inflammatory bowel disease (IBD) care necessitate greater patient activation and self-efficacy, measures associated with positive health outcomes.MethodsWe assessed change in patient activation and general self-efficacy from baseline to 12 months through our TELEmedicine for IBD trial, a multicenter, randomized controlled...
Published in Digestive Diseases and Sciences
BackgroundHepatic encephalopathy (HE) is associated with substantial morbidity and mortality, contributing significant burden on healthcare systems.AimWe aim to evaluate trends in clinical and economic burden of HE among hospitalized adults in the USA.MethodsUsing the 2010–2014 National Inpatient Sample, we identified adults hospitalized with HE us...
Published in Digestive Diseases and Sciences
BackgroundThe differential impact of anti-tumor necrosis factor (anti-TNF) therapy with methotrexate versus thiopurine co-therapy on endoscopic remission remains uncertain.AimsTo compare rates of endoscopic remission based on methotrexate or thiopurine co-therapy used with anti-TNF therapy in Crohn’s disease.MethodsA retrospective observational stu...
Published in Digestive Diseases and Sciences
Eosinophilic esophagitis (EoE) is an immune-mediated disease triggered by food antigens for which dietary elimination treatment can induce and sustain histologic remission. Our review aims to describe the state of the art regarding dietary treatment of EoE, highlighting a number of areas of controversy related to dietary therapy in EoE, including n...
Published in Digestive Diseases and Sciences
BackgroundEphA3 is a member of Eph receptors, which is involved in tumorigenesis. The expression and clinical significance of EphA3 in colorectal cancer (CRC) have not been fully investigated.MethodsFour colon cancer cell lines and a set of CRC tissues were examined for EphA3 expression. The methylation status of a CpG island within the EphA3 promo...
Published in Digestive Diseases and Sciences
BackgroundHuntingtin-associated protein 1 (HAP1) is a neuronal protein that is predominantly expressed in neurons in the brain. HAP1 is critical for maintenance of neuronal survival as well as regulation of food intake and body weight in animals. In addition to the critical role of HAP1 in the central nervous system, HAP1 is also found in endocrine...
Published in Digestive Diseases and Sciences
Published in Digestive Diseases and Sciences
BackgroundThe aim of this study was to assess the relationship of serum vedolizumab concentrations (SVC) during induction and endoscopic remission in patients with inflammatory bowel diseases (IBD) after 52 weeks of therapy with vedolizumab. We also sought to assess the incidence of antibody to vedolizumab (ATV) formation, the effect of ATV on drug...
Published in Digestive Diseases and Sciences
BackgroundIκB kinase 2 (IKK2) is the primary catalytic subunit of the IKK complex. Activation of IKK phosphorylates the inhibitors of NF-κB (IκB), triggering the translocation of NF-κB.AimsAlthough IKK2 has been investigated in the inflammation-cancer transformation of gastric epithelium, its role in gastric cancer (GC) cells remained unexplored.Me...
Published in Digestive Diseases and Sciences
As the demand for liver transplantation continues to rise, the scarcity of liver donor grafts has led to the use of extended criteria grafts for liver transplantation in select group of patients. Hepatitis C-seropositive liver grafts have been used primarily in hepatitis C-positive recipients, with studies showing non-inferior outcomes when compare...
