Skytte, Mads J Samkani, Amirsalar Petersen, Amy D Thomsen, Mads N Astrup, Arne Chabanova, Elizaveta Frystyk, Jan Holst, Jens J Thomsen, Henrik S Madsbad, Sten
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Published in
Diabetologia
Dietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in carbohydrate content is acknowledged. We compared a carbohydrate-reduced high-protein (CRHP) diet with an iso-energetic conventional diabetes (CD) diet to elucidate the effects on glycaemic control and selected cardiovascular risk mar...
Majumder, Syamantak Hadden, Mitchell J Thieme, Karina Batchu, Sri N Niveditha, Divya Chowdhury, Shibasish Yerra, Veera Ganesh Advani, Suzanne L Bowskill, Bridgit B Liu, Youan
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Published in
Diabetologia
Long non-coding RNAs (lncRNAs) are garnering increasing attention for their putative roles in the pathogenesis of chronic diseases, including diabetic kidney disease (DKD). However, much about in vivo lncRNA functionality in the adult organism remains unclear. To better understand lncRNA regulation and function in DKD, we explored the effects of th...
Staels, Willem Heremans, Yves Heimberg, Harry De Leu, Nico
Published in
Diabetologia
Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progres...
Beijer, Kristina Nowak, Christoph Sundström, Johan Ärnlöv, Johan Fall, Tove Lind, Lars
Published in
Diabetologia
The pathogenesis of type 2 diabetes is not fully understood. We investigated whether circulating levels of preselected proteins were associated with the outcome 'diabetes' and whether these associations were causal. In 2467 individuals of the population-based, cross-sectional EpiHealth study (45-75 years, 50% women), 249 plasma proteins were analys...
Boldison, Joanne Da Rosa, Larissa C Buckingham, Lucy Davies, Joanne Wen, Li Wong, F Susan
Published in
Diabetologia
Autoreactive B cells escape immune tolerance and contribute to the pathogenesis of type 1 diabetes. While global B cell depletion is a successful therapy for autoimmune disease, the fate of autoreactive cells during this treatment in autoimmune diabetes is unknown. We aimed to identify and track anti-insulin B cells in pancreatic islets and underst...
Postigo-Fernandez, Jorge Farber, Donna L Creusot, Rémi J
Published in
Diabetologia
Tolerance induction in lymph nodes can be mediated by both haematopoietic cells (e.g. specific dendritic cells subsets) and by non-haematopoietic cells (e.g. lymph node stromal cells [LNSCs]) when they present peripheral tissue antigens to autoreactive T cells. LNSCs normally regulate T cell trafficking and survival and help to maintain peripheral ...
Herrero-Cervera, Andrea Vinué, Ángela Burks, Deborah J González-Navarro, Herminia
Published in
Diabetologia
Non-alcoholic fatty liver disease (NAFLD) is frequently associated with type 2 diabetes mellitus. Progression of NAFLD is mediated, among other things, by activation of inflammatory pathways. In the present study, the role of the proinflammatory cytokine LIGHT (TNFSF14) was explored in NAFLD and type 2 diabetes mellitus in mice deficient for the cy...
Steinarsson, Andri O Rawshani, Araz Gudbjörnsdottir, Soffia Franzén, Stefan Svensson, Ann-Marie Sattar, Naveed
Published in
Diabetologia
Unfortunately, the symbols in Fig. 1 were incorrectly described in the legend.
Yang, Xiao Zhao, Yang Sun, Qi Yang, Yunxia Gao, Yan Ge, Wenhao Liu, Junhao Xu, Xi Weng, Dan Wang, Shiming
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Published in
Diabetologia
Plasma 5'-AMP (pAMP) is elevated in mouse models of type 2 diabetes. However, the metabolic regulatory role of adenine nucleotides in type 2 diabetes remains unclear. Adenine nucleotides and their metabolites in plasma and liver were examined by HPLC. 1H NMR-based metabolomics analysis was performed to explore the changes of metabolites in mouse mo...
Hockett, Christine W Harrall, Kylie K Moore, Brianna F Starling, Anne P Bellatorre, Anna Sauder, Katherine A Perng, Wei Scherzinger, Ann Garg, Kavita Ringham, Brandy M
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Published in
Diabetologia
We previously showed that intrauterine exposure to gestational diabetes mellitus (GDM) increases selected markers of adiposity in pre-pubertal adolescents. In the present study, we examined these associations in adolescence, and explored whether they are strengthened as the participants transition through puberty. Data from 597 individuals (505 une...
