Fleming, G Alexander Petrie, John R Bergenstal, Richard M Holl, Reinhard W Peters, Anne L Heinemann, Lutz
Published in
Diabetologia
Digital health technology, especially digital and health applications ('apps'), have been developing rapidly to help people manage their diabetes. Numerous health-related apps provided on smartphones and other wireless devices are available to support people with diabetes who need to adopt either lifestyle interventions or medication adjustments in...
Oshima, Masaya Pechberty, Séverine Bellini, Lara Göpel, Sven O Campana, Mélanie Rouch, Claude Dairou, Julien Cosentino, Cristina Fantuzzi, Federica Toivonen, Sanna
...
Published in
Diabetologia
During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion by insulin-producing pancreatic beta cells. The majority of data on the deleterious effects of lipids on functional beta cell mass were obtained either in vivo in rodent models or in vitro using rodent islet...
Jun, Goo Aguilar, David Evans, Charles Burant, Charles F Hanis, Craig L
Published in
Diabetologia
To understand the complex metabolic changes that occur long before the diagnosis of type 2 diabetes, we investigated differences in metabolomic profiles in plasma between prediabetic and normoglycaemic individuals for subtypes of prediabetes defined by fasting glucose, 2 h glucose and HbA1c measures. Untargeted metabolomics data were obtained from ...
Rolandsson, Olov Hampe, Christiane S Sharp, Stephen J Ardanaz, Eva Boeing, Heiner Fagherazzi, Guy Mancini, Francesca Romana Nilsson, Peter M Overvad, Kim Chirlaque, Maria-Dolores
...
Published in
Diabetologia
Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. ...
Ellingsgaard, Helga Seelig, Eleonora Timper, Katharina Coslovsky, Michael Soederlund, Line Lyngbaek, Mark P Wewer Albrechtsen, Nicolai J Schmidt-Trucksäss, Arno Hanssen, Henner Frey, Walter O
...
Published in
Diabetologia
IL-6 is a cytokine with various effects on metabolism. In mice, IL-6 improved beta cell function and glucose homeostasis via upregulation of glucagon-like peptide 1 (GLP-1), and IL-6 release from muscle during exercise potentiated this beneficial increase in GLP-1. This study aimed to identify whether exercise-induced IL-6 has a similar effect in h...
Sayers, Sophie R Beavil, Rebecca L Fine, Nicholas H F Huang, Guo C Choudhary, Pratik Pacholarz, Kamila J Barran, Perdita E Butterworth, Sam Mills, Charlotte E Cruickshank, J Kennedy
...
Published in
Diabetologia
Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance in mouse models of diabetes. Despite this, the ...
Bizino, Maurice B Jazet, Ingrid M de Heer, Paul van Eyk, Huub J Dekkers, Ilona A Rensen, Patrick C N Paiman, Elisabeth H M Lamb, Hildebrandus J Smit, Johannes W
Published in
Diabetologia
The aim of this work was to assess the effect of liraglutide on ectopic fat accumulation in individuals with type 2 diabetes mellitus. This study is a pre-specified subanalysis of the MAGNetic resonance Assessment of VICTOza efficacy in the Regression of cardiovascular dysfunction In type 2 diAbetes mellitus (MAGNA VICTORIA) study, with primary end...
Yuan, Shuai Larsson, Susanna C
Published in
Diabetologia
Epidemiological data on the associations of circulating fatty acid levels with type 2 diabetes are inconsistent. We conducted a two-sample Mendelian randomisation study to explore the causal associations of plasma levels of ten fatty acids with type 2 diabetes and glycaemic traits. Thirteen SNPs associated with circulating levels of ten individual ...
Ventriglia, Giuliana Mancarella, Francesca Sebastiani, Guido Cook, Dana P Mallone, Roberto Mathieu, Chantal Gysemans, Conny Dotta, Francesco
Published in
Diabetologia
MicroRNAs (miRNAs) are a novel class of potential biomarkers emerging in many diseases, including type 1 diabetes. Here, we aim to analyse a panel of circulating miRNAs in non-obese diabetic (NOD) mice and individuals with type 1 diabetes. We adopted standardised methodologies for extracting miRNAs from small sample volumes to evaluate a profiling ...
Bandosz, Piotr Ahmadi-Abhari, Sara Guzman-Castillo, Maria Pearson-Stuttard, Jonathan Collins, Brendan Whittaker, Hannah Shipley, Martin J Capewell, Simon Brunner, Eric J O'Flaherty, Martin
...
Published in
Diabetologia
Diabetes is associated with an increased risk of dementia. We estimated the potential impact of trends in diabetes prevalence upon mortality and the future burden of dementia and disability in England and Wales. We used a probabilistic multi-state, open cohort Markov model to integrate observed trends in diabetes, cardiovascular disease and dementi...
