Arshi, Banafsheh Chen, Jinluan Ikram, M Arfan Zillikens, M Carola Kavousi, Maryam
Published in
Diabetologia
The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study. We assessed the cross-sectional association between SAF and prevalent heart failure among 242...
Ling, Charlotte
Published in
Diabetologia
Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers epigenetic biomarkers that predict response to therapy, therapy-ind...
Tuchman, Arleen M
Published in
Diabetologia
This article offers an historical approach to exploring precision medicine's potential for reducing health disparities in diabetes. It examines case studies from the twentieth-century USA, from early twentieth-century beliefs that Jews were most at risk of developing diabetes to claims in the 1980s that Native Americans, African Americans, Hispanic...
Herder, Christian Roden, Michael
Published in
Diabetologia
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies and some insufficiently defined clinical features, does not reflect differences in aetiological mechanisms and in the clinical course of people with diabetes. This review discusses evidence from recent studies addressing the complexity of diabetes by proposin...
Bonner, Caroline Saponaro, Chiara
Published in
Diabetologia
Bonnefond, Amélie Semple, Robert K
Published in
Diabetologia
Integration of genomic and other data has begun to stratify type 2 diabetes in prognostically meaningful ways, but this has yet to impact on mainstream diabetes practice. The subgroup of diabetes caused by single gene defects thus provides the best example to date of the vision of 'precision diabetes'. Monogenic diabetes may be divided into primary...
Sparks, Joshua R Ghildayal, Nidhi Hivert, Marie-France Redman, Leanne M
Published in
Diabetologia
Gestational diabetes mellitus (GDM) is the most prevalent pregnancy-related endocrinopathy, affecting up to 25% of pregnancies worldwide. Pregnant individuals who develop GDM have an increased risk of complications during pregnancy and birth, as well as future development of type 2 diabetes mellitus and CVD. This increased risk is subsequently pass...
Merino, Jordi
Published in
Diabetologia
Diet plays a fundamental role in maintaining long-term health, with healthful diets being endorsed by current dietary guidelines for the prevention and management of type 2 diabetes. However, the response to dietary interventions varies widely, highlighting the need for refinement and personalisation beyond population-based 'one size fits all'. Thi...
Sørensen, Thorkild I A Metz, Sophia Kilpeläinen, Tuomas O
Published in
Diabetologia
The past decades have seen a rapid global rise in the incidence of type 2 diabetes. This surge has been driven by diabetogenic environmental changes that may act together with a genetic predisposition to type 2 diabetes. It is possible that there is a synergistic gene-environment interaction, where the effects of the diabetogenic environment depend...
Hermanns, Norbert Ehrmann, Dominic Shapira, Amit Kulzer, Bernhard Schmitt, Andreas Laffel, Lori
Published in
Diabetologia
Monitoring of glucose plays an essential role in the management of diabetes. However, to fully understand and meaningfully interpret glucose levels, additional information on context is necessary. Important contextual factors include data on behaviours such as eating, exercise, medication-taking and sleep, as well as data on mental health aspects s...
