Parkkola, Anna Turtinen, Maaret Härkönen, Taina Ilonen, Jorma Knip, Mikael
Published in
Diabetologia
Shared aetiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. We wanted to characterise the family history of type 2...
Cottle, Louise Gan, Wan Jun Gilroy, Ian Samra, Jaswinder S Gill, Anthony J Loudovaris, Thomas Thomas, Helen E Hawthorne, Wayne J Kebede, Melkam A Thorn, Peter
...
Published in
Diabetologia
We hypothesised that human beta cells are structurally and functional polarised with respect to the islet capillaries. We set out to test this using confocal microscopy to map the 3D spatial arrangement of key proteins and live-cell imaging to determine the distribution of insulin granule fusion around the cells. Human pancreas samples were rapidly...
Wargny, Matthieu Potier, Louis Gourdy, Pierre Pichelin, Matthieu Amadou, Coralie Benhamou, Pierre-Yves Bonnet, Jean-Baptiste Bordier, Lyse Bourron, Olivier Chaumeil, Claude
...
Published in
Diabetologia
Aims/hypothesis This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The CORONADO initiative is a French nationwide multicentre ...
McGovern, Andrew P. Thomas, Nick J. Vollmer, Sebastian J. Hattersley, Andrew T. Mateen, Bilal A. Dennis, John M.
Published in
Diabetologia
Nanayakkara, Natalie Curtis, Andrea J Heritier, Stephane Gadowski, Adelle M Pavkov, Meda E Kenealy, Timothy Owens, David R Thomas, Rebecca L Song, Soon Wong, Jencia
...
Published in
Diabetologia
Few studies examine the association between age at diagnosis and subsequent complications from type 2 diabetes. This paper aims to summarise the risk of mortality, macrovascular complications and microvascular complications associated with age at diagnosis of type 2 diabetes. Data were sourced from MEDLINE and All EBM (Evidence Based Medicine) data...
Mousavy Gharavy, S. Neda Owen, Bryn M. Millership, Steven J. Chabosseau, Pauline Pizza, Grazia Martinez-Sanchez, Aida Tasoez, Emirhan Georgiadou, Eleni Hu, Ming Fine, Nicholas H. F.
...
Published in
Diabetologia
Aims/hypothesis Variants close to the VPS13C / C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B . Methods CRISPR/Cas9-induced global C2cd4b -knockout mice an...
Luk, Andrea O Y Wu, Hongjiang Lau, Eric S H Yang, Aimin So, Wing-Yee Chow, Elaine Kong, Alice P S Hui, David S C Ma, Ronald C W Chan, Juliana C N
...
Published in
Diabetologia
Infection is an under-recognised but important complication in people with diabetes. Studies on temporal trends in incidence of infection in this population are limited. We report the trends in infection-related hospitalisation in people with diabetes and compared hospitalisation rates between people with and without diabetes in Hong Kong. Hospital...
Li, Bin Yu, Yijin Liu, Kun Zhang, Yuping Geng, Qi Zhang, Feng Li, Yanning Qi, Jinsheng
Published in
Diabetologia
Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of BHB in promoting the generation of claudin-5 t...
Bock, Patricia M Telo, Gabriela H Ramalho, Rafaela Sbaraini, Mariana Leivas, Gabriel Martins, Andreza F Schaan, Beatriz D
Published in
Diabetologia
The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. MEDLINE, EMBASE and the Cochrane Library were searched. The eligibility criteria for the ...
Gar, Christina Haschka, Stefanie J. Kern-Matschilles, Stefanie Rauch, Barbara Sacco, Vanessa Prehn, Cornelia Adamski, Jerzy Seissler, Jochen Wewer Albrechtsen, Nicolai J. Holst, Jens J.
...
Published in
Diabetologia
Aims/hypothesis Many individuals who develop type 2 diabetes also display increased glucagon levels (hyperglucagonaemia), which we have previously found to be associated with the metabolic syndrome. The concept of a liver–alpha cell axis provides a possible link between hyperglucagonaemia and elevated liver fat content, a typical finding in the met...