Holt, Richard I. G. DeVries, J. Hans Hess-Fischl, Amy Hirsch, Irl B. Kirkman, M. Sue Klupa, Tomasz Ludwig, Barbara Nørgaard, Kirsten Pettus, Jeremy Renard, Eric
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Published in
Diabetologia
The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and technologies and addressed the following topics: diagnosis, aims ...
Remie, Carlijn M. E. Janssens, Georges E. Bilet, Lena van Weeghel, Michel Duvivier, Bernard M. F. M. de Wit, Vera H. W. Connell, Niels J. Jörgensen, Johanna A. Schomakers, Bauke V. Schrauwen-Hinderling, Vera B.
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Published in
Diabetologia
Aims/hypothesis In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has been suggested that replacing sitting time by standing and walking could be beneficial for individuals with type 2 diabetes but the underlying mechanisms are unknown and direct comparisons with...
Sen, Taha Li, Jingwei Neuen, Brendon L. Neal, Bruce Arnott, Clare Parikh, Chirag R. Coca, Steven G. Perkovic, Vlado Mahaffey, Kenneth W. Yavin, Yshai
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Published in
Diabetologia
Aims/hypothesis Higher plasma concentrations of tumour necrosis factor receptor (TNFR)-1, TNFR-2 and kidney injury molecule-1 (KIM-1) have been found to be associated with higher risk of kidney failure in individuals with type 2 diabetes in previous studies. Whether drugs can reduce these biomarkers is not well established. We measured these biomar...
Nel, Isabelle Beaudoin, Lucie Gouda, Zouriatou Rousseau, Camille Soulard, Pauline Rouland, Matthieu Bertrand, Léo Boitard, Christian Larger, Etienne Lehuen, Agnès
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Published in
Diabetologia
Aims/hypothesis Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes expressing an αβ T cell antigen receptor that recognises the MHC-related 1 molecule. MAIT cells are altered in children at risk for and with type 1 diabetes, and mouse model studies have shown MAIT cell involvement in type 1 diabetes development. Since several...
Fang, Michael Ishigami, Junichi Echouffo-Tcheugui, Justin B. Lutsey, Pamela L. Pankow, James S. Selvin, Elizabeth
Published in
Diabetologia
Aims/hypothesis The aim of this work was to assess the association between diabetes and risk for infection-related hospitalisation and mortality. Methods We conducted a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Diabetes was defined as a fasting glucose ≥7 mmol/l or non-fasting glucose ≥11.1 mmol/l, self-re...
Tran-Duy, An Knight, Josh Clarke, Philip M. Svensson, Ann-Marie Eliasson, Björn Palmer, Andrew J.
Published in
Diabetologia
Aims/hypothesis Tables reporting life expectancies by common risk factors are available for individuals with type 2 diabetes; however, there is currently no published equivalent for individuals with type 1 diabetes. We aimed to develop a life expectancy table using a recently published simulation model for individuals with type 1 diabetes. Methods ...
Saravanan, Ponnusamy Sukumar, Nithya Adaikalakoteswari, Antonysunil Goljan, Ilona Venkataraman, Hema Gopinath, Amitha Bagias, Christos Yajnik, Chittaranjan S. Stallard, Nigel Ghebremichael-Weldeselassie, Yonas
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Published in
Diabetologia
Aims/hypothesis The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide in all ethnic groups. Low vitamin B12 and low/high folate levels may contribute to GDM risk, but there is conflicting evidence. Our aim is to assess the relationships of early pregnancy vitamin B12 and folate levels with the risk of GDM status at 26–28 wee...
Wang, Xuan Younis, Shady Cen, Jing Wang, Yun Krizhanovskii, Camilla Andersson, Leif Welsh, Nils
Published in
Diabetologia
Aims/hypothesis ZBED6 (zinc finger, BED-type containing 6) is known to regulate muscle mass by suppression of Igf2 gene transcription. In insulin-producing cell lines, ZBED6 maintains proliferative capacity at the expense of differentiation and beta cell function. The aim was to study the impact of Zbed6 knockout on beta cell function and glucose t...
Gu, Yong Jia, Xiaofan Vartak, Tanwi Miao, Dongmei Dong, Fran Jerram, Samuel T. Rewers, Marian Ferrara, Assiamira Lawrence, Jean M. Yu, Liping
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Published in
Diabetologia
Aims/hypothesis It is important to differentiate the two major phenotypes of adult-onset diabetes, autoimmune type 1 diabetes and non-autoimmune type 2 diabetes, especially as type 1 diabetes presents in adulthood. Serum GAD65 autoantibodies (GADA) are the most sensitive biomarker for adult-onset autoimmune type 1 diabetes, but the clinical value o...
Thomas, Nicholas J. Dennis, John M. Sharp, Seth A. Kaur, Akaal Misra, Shivani Walkey, Helen C. Johnston, Desmond G. Oliver, Nick S. Hagopian, William A. Weedon, Michael N.
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Published in
Diabetologia
Aims/hypothesis Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to qua...
