Rhee, Jinnie J Han, Jialin Montez-Rath, Maria E Chertow, Glenn M
Published in
Diabetes, obesity & metabolism
To determine the comparative effectiveness regarding major cardiovascular events of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). We assembled a cohort of commercially insured adult patients with T2DM in the ...
Chen, Gui-Ling Liu, Yang Gao, Xue-Feng Wu, Kai-Qi Yang, Yun-Kai Chen, Yong Peng, Cong-Gao Jin, Ting-Han Huang, Yu-Bao Zhang, Yao-Wen
...
Published in
Diabetes, obesity & metabolism
Novel long-acting drugs for type 2 diabetes mellitus may optimize patient compliance and glycaemic control. Exendin-4-IgG4-Fc (E4F4) is a long-acting glucagon-like peptide-1 receptor agonist. This first-in-human study investigated the safety, tolerability, pharmacokinetic, pharmacodynamic and immunogenicity profiles of a single subcutaneous injecti...
Roth, Christian L McCormack, Shana E
Published in
Diabetes, obesity & metabolism
Hypothalamic obesity (HO) is a rare and complex disorder that confers substantial morbidity and excess mortality. HO is a unique subtype of obesity characterized by impairment in the key brain pathways that regulate energy intake and expenditure, autonomic nervous system function, and peripheral hormonal signalling. HO often occurs in the context o...
Tomlinson, Jeremy W
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Diabetes, obesity & metabolism
Bardet-Biedl syndrome (BBS) is a rare, monogenic, multisystem disorder characterized by retinal dystrophy, renal abnormalities, polydactyly, learning disabilities, as well as metabolic dysfunction, including obesity and an increased risk of type 2 diabetes. It is a primary ciliopathy, and causative mutations in more than 25 different genes have bee...
Strombotne, Kiersten L Lum, Jessica Pizer, Steven D Figueroa, Stuart Frakt, Austin B Conlin, Paul R
Published in
Diabetes, obesity & metabolism
We previously evaluated the impacts at 5 months of a digitally delivered coaching intervention in which participants are instructed to adhere to a very low carbohydrate, ketogenic diet. With extended follow-up (24 months), we assessed the longer-term effects of this intervention on changes in clinical outcomes, health care utilization and costs ass...
Ebekozien, Osagie Fantasia, Kathryn Farrokhi, Farnoosh Sabharwal, Ashutosh Kerr, David
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Diabetes, obesity & metabolism
Digital health technologies are being utilized increasingly in the modern management of diabetes. These include tools such as continuous glucose monitoring systems, connected blood glucose monitoring devices, hybrid closed-loop systems, smart insulin pens, telehealth, and smartphone applications (apps). Although many of these technologies have a so...
Shugaa Addin, Nuha Niedermayer, Fiona Thorand, Barbara Linseisen, Jakob Seissler, Jochen Peters, Annette Rospleszcz, Susanne
Published in
Diabetes, obesity & metabolism
To assess the association of serum magnesium with prevalent and incident metabolic syndrome (MetS) and its individual components in the general population and to examine any effect modification by chronic kidney disease (CKD) status. We analysed longitudinal data from the population-based KORA F4/FF4 study, including 2996 participants (387 with CKD...
Chen, Jianrong Feng, Xianjie Zhou, Xu Li, Yong
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Diabetes, obesity & metabolism
Emerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiq...
Braune, Katarina Hussain, Sufyan Lal, Rayhan Leibrand, Scott Lewis, Dana M O'Donnell, Shane
Published in
Diabetes, obesity & metabolism
Davis, Timothy M E Maxwell, Sharon Chan, Cathy Keen, Helen I Davis, Wendy A
Published in
Diabetes, obesity & metabolism
