Zhang, You-Zhi Zhang, Yu-Lin Huang, Qi Huang, Cong Jiang, Zhi-Long Cai, Fei Shen, Jian-Fen
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Diabetes, metabolic syndrome and obesity : targets and therapy
Hypoadiponectinemia is a high risk factor for type 2 diabetes and cardiovascular disease. Although adiponectin is a protective molecule in cardiovascular diseases, it is hampered due to short plasma half-life and high cost of production. This study aimed to investigate whether AdipoRon, a small-molecule adiponectin receptor agonist, alleviated satu...
Zhu, Wanqiu Niu, Xin Wang, Mingxia Li, Zhao Jiang, Hong-Kun Li, Chuntao Caton, Samantha J Bai, Yinglong
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Diabetes, metabolic syndrome and obesity : targets and therapy
Consumption of industrially produced trans-fatty acids (iTFAs) can result in alteration to lipid profile and glucose metabolism. Moreover, a diet high in iTFAs could increase the risk of obesity, cardiovascular diseases (CVDs) and type 2 diabetes mellitus. Glucose and lipid metabolism are closely linked in white adipose tissue (WAT), yet the underl...
Wang, Na Yang, Tao Li, Jie Zhang, Xianfeng
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Diabetes, metabolic syndrome and obesity : targets and therapy
Addition of the dipeptidyl peptidase-4 (DPP4) inhibitors to insulin in patients with type 2 diabetes mellitus (T2DM) may achieve better glycemic control. However, results of pilot randomized controlled trials (RCTs) are inconsistent. We aimed to perform a meta-analysis of RCTs to evaluate efficacy and safety of DPP4 inhibitors compared with placebo...
Nadi, Maryam Bambaeichi, Effat Marandi, Seyyed Mohammad
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Diabetes, metabolic syndrome and obesity : targets and therapy
The purpose of this study was to compare the effect of 12 weeks of low-intensity resistance training and exercises for peripheral neuropathy (EPN) on the inflammatory and physiological conditions, balance, and complications of diabetic neuropathy in female patients. 45 women with mild to moderate diabetic neuropathy and an average age of 55.46±3.06...
Moukayed, Meis Grant, William B
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Diabetes, metabolic syndrome and obesity : targets and therapy
The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, increased health costs, poorer qu...
Woodman, Owen L Ortega, Jacinta M Hart, Joanne L Klein, Thomas Potocnik, Simon
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Diabetes, metabolic syndrome and obesity : targets and therapy
The aim of this study was to investigate the effects of the type-4 dipeptidyl peptidase (DPP-4) inhibitors linagliptin and vildagliptin as well as the sulfonylurea glimepiride on endothelium-dependent relaxation of aortae from female db/db mice with established hyperglycemia to determine whether these treatments were able to attenuate diabetes-indu...
Liang, Zi-Hong Jia, Yan-Bo Li, Zi-Ru Li, Min Wang, Mei-Ling Yun, Yong-Li Yu, Li-Jun Shi, Lei Zhu, Run-Xiu
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Diabetes, metabolic syndrome and obesity : targets and therapy
Depression can seriously affect the quality of life of type 2 diabetes mellitus (T2DM) patients after stroke. However, there were still no objective methods to diagnose T2DM patients with poststroke depression (PSD). Therefore, we conducted this study to deal with this problem. Gas chromatography-mass spectroscopy (GC-MS)-based metabolomics profili...
Rahmanian, Karamatollah Shojaei, Mohammad Sotoodeh Jahromi, Abdolreza
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Diabetes, metabolic syndrome and obesity : targets and therapy
The incidence of obesity is globally increasing and it is a predisposing factor for morbidity and mortality. This study assessed the prevalence of metabolically unhealthy (MU) individuals and its determinants according to body mass index (BMI). In our cross-sectional study, 891 persons aged 30 years or older participated. Participants were classifi...
Hwang, Seo Eun Kwon, Hyuktae Jeong, Su-Min Kim, Hyun-Jin Park, Jin-Ho
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Diabetes, metabolic syndrome and obesity : targets and therapy
Although some studies have tried to determine the impact of long-term air pollution exposure on obesity, they have mainly focused on body mass index (BMI) and the results are inconsistent. Therefore, we investigated the association of annual ambient air pollution exposure with various obesity traits, including computed tomography-measured abdominal...
Shafie Pour, M R Sadeghiyeh, T Hadavi, M Besharati, M Bidaki, R
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Diabetes, metabolic syndrome and obesity : targets and therapy
The decision to start insulin therapy is often difficult. Determining the barriers against insulin therapy initiation can facilitate care and treatment strategies. The aim of this study was to evaluate the barriers against initiating insulin therapy among patients with diabetes living in Yazd, Iran. This descriptive study was conducted on 214 patie...
