Wake, Addisu Dabi
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Diabetes, metabolic syndrome and obesity : targets and therapy
Despite the improvements in clinical care of the patients, research updates, and public health interventions, there is still an increase in the prevalence, incidence, and mortality because of diabetes mellitus (DM). DM is a public health problem in both developed and developing countries. It has increased alarmingly, putting this disease in the dim...
Parada D, David Peña G, Karla B Vives, Margarida Molina, Alicia Mayayo, Emilio Riu, Frances Sabench, Fàtima Del Castillo, Daniel
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Diabetes, metabolic syndrome and obesity : targets and therapy
The cellular distribution of ghrelin positive cells is not well defined. The aim of the study is to quantify and determine the distribution of ghrelin cells in gastric mucosa in patients with morbid obesity and relate this finding to gender, comorbidities, gastritis, and plasmatic levels of acyl and desacylghrelin before and after laparoscopic slee...
Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong
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Diabetes, metabolic syndrome and obesity : targets and therapy
Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of...
Pengpid, Supa Peltzer, Karl
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Diabetes, metabolic syndrome and obesity : targets and therapy
The study aimed to investigate the associations between skipping breakfast and various health risk behaviours and mental health in university students in 28 countries. Using a cross-sectional study design, 21,972 university students with a median age of 20 years from 28 countries in Africa, the Americas and Asia, replied to self-reported measures o...
Ramalingam, Latha Sopontammarak, Boontharick Menikdiwela, Kalhara R Moustaid-Moussa, Naima
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Diabetes, metabolic syndrome and obesity : targets and therapy
The renin angiotensin aldosterone system (RAAS) is a hormone system known for its role in regulating blood pressure and fluid balance. Numerous RAAS inhibitors routinely prescribed for hypertension have also beneficial effects in type 2 diabetes (T2D) prevention. RAAS components are expressed locally in many tissues, including adipose tissue and pa...
Liu, Peng Ju Lou, Hui Ping Zhu, Yan Ning
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Diabetes, metabolic syndrome and obesity : targets and therapy
It has been suggested that hypertriglyceridemic waist (HW) phenotype is strongly associated with metabolic syndrome (MetS); however, there are very limited studies integrating triglyceride (TG) and waist circumference (WC) into a continuous variable to investigate the predictive power of this phenotype. Inspired from the triglyceride glucose index ...
Qi, Chen-Xing Huang, Xin Shen, Yin
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Diabetes, metabolic syndrome and obesity : targets and therapy
The current study aimed to apply the amplitude of low-frequency fluctuation (ALFF) method for investigating the spontaneous brain activity alterations and their relationships with clinical features in patients with diabetic retinopathy (DR). In total, 35 patients with DR (18 males and 17 females) and 38 healthy control (HC) subjects (18 males and 2...
Johannesen, Christina Osland Dale, Hanna Fjeldheim Jensen, Caroline Lied, Gülen Arslan
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Diabetes, metabolic syndrome and obesity : targets and therapy
According to the rising prevalence of obesity and metabolic disorders leading to impaired glucose metabolism, effective strategies to prevent and/or delay the onset of disease are of great need. A plant-based diet has been suggested as an effective lifestyle change that may reduce the degree of obesity and improve outcomes related to glucose metabo...
Sadeghi, Erfan Hosseini, Sayed Mohsen Vossoughi, Mehrdad Aminorroaya, Ashraf Amini, Massoud
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Diabetes, metabolic syndrome and obesity : targets and therapy
Dyslipidemia is claimed to be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, first-degree relatives (FDRs) of patients with T2DM are reported to be at higher risk. The aim of this study was to evaluate the association between serum lipid profile and T2DM incidence in FDRs. Information on 1222 T2DM FDRs during 14 year...
Yu, Wenshu Wu, Na Li, Ling OuYang, Hong Qian, Meichen Shen, Haitao
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Diabetes, metabolic syndrome and obesity : targets and therapy
Gestational diabetes mellitus (GDM) is associated with many adverse obstetric outcomes and neonatal outcomes, including preeclampsia, Cesarean section, and macrosomia. Active screening and early diabetes control can reduce the occurrence of adverse outcomes. Glycosylated hemoglobin (HbA1c) only reflects average blood glucose levels, but not glycemi...