Cromer, Sara J Lakhani, Chirag M Mercader, Josep M Majarian, Timothy D Schroeder, Philip Cole, Joanne B Florez, Jose C Patel, Chirag J Manning, Alisa K Burnett-Bowie, Sherri-Ann M
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Published in
Diabetes care
Quantify the impact of genetic and socioeconomic factors on risk of type 2 diabetes (T2D) and obesity. Among participants in the Mass General Brigham Biobank (MGBB) and UK Biobank (UKB), we used logistic regression models to calculate cross-sectional odds of T2D and obesity using 1) polygenic risk scores for T2D and BMI and 2) area-level socioecono...
McKeigue, Paul M McGurnaghan, Stuart Blackbourn, Luke Bath, Louise E McAllister, David A Caparrotta, Thomas M Wild, Sarah H Wood, Simon N Stockton, Diane Colhoun, Helen M
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Published in
Diabetes care
Studies using claims databases reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection >30 days earlier was associated with an increase in the incidence of type 1 diabetes. Using exact dates of diabetes diagnosis from the national register in Scotland linked to virology laboratory data, we sought to replicate this findi...
Lehmann, Vera Föll, Simon Maritsch, Martin van Weenen, Eva Kraus, Mathias Lagger, Sophie Odermatt, Katja Albrecht, Caroline Fleisch, Elgar Zueger, Thomas
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Published in
Diabetes care
To develop a noninvasive hypoglycemia detection approach using smartwatch data. We prospectively collected data from two wrist-worn wearables (Garmin vivoactive 4S, Empatica E4) and continuous glucose monitoring values in adults with diabetes on insulin treatment. Using these data, we developed a machine learning (ML) approach to detect hypoglycemi...
Akhtari, Farida S Lloyd, Dillon Burkholder, Adam Tong, Xiaoran House, John S Lee, Eunice Y Buse, John Schurman, Shepherd H Fargo, David C Schmitt, Charles P
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Published in
Diabetes care
Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicability of results. We conducted an exposome-wide association study in the multiancestry Personalized Environment ...
Sasidharan Pillai, Sabitha Has, Phinnara Quintos, Jose Bernardo Serrano Gonzalez, Monica Kasper, Vania L Topor, Lisa Swartz Fredette, Meghan E
Published in
Diabetes care
To describe the evolving impact of the coronavirus disease 2019 pandemic on the incidence and presentation of new-onset pediatric type 2 diabetes. Retrospective medical record review of youth with new-onset type 2 diabetes comparing the prepandemic period (1 January 2017-29 February 2020) with the first (1 March 2020-31 December 2020) and second pa...
Andersen, Mette K Ängquist, Lars Bork-Jensen, Jette Jonsson, Anna E Stinson, Sara E Sandholt, Camilla H Thodberg, Malte Pikkupeura, Laura Maarit Ongstad, Emily L Grarup, Niels
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Published in
Diabetes care
The association between FTO rs9939609 and obesity is modified by physical activity (PA) and/or insulin sensitivity (IS). We aimed to assess whether these modifications are independent, to assess whether PA and/or IS modify the association between rs9939609 and cardiometabolic traits, and to elucidate underlying mechanisms. Genetic association analy...
Lee, You-Bin Kim, Gyuri Jun, Ji Eun Park, Hyunjin Lee, Woo Je Hwang, You-Cheol Kim, Jae Hyeon
Published in
Diabetes care
We investigated the efficacy of an integrated digital health care platform with artificial intelligence (AI)-based dietary management in adults with type 2 diabetes (T2D). In this 48-week, open-label, randomized, multicenter clinical trial, overweight or obese adults with T2D were randomly assigned to one of three groups in a 1:1:1 ratio: group A r...
Holman, Naomi Barron, Emma Young, Bob Gregg, Edward W Khunti, Kamlesh Valabhji, Jonathan Sattar, Naveed
Published in
Diabetes care
The incidence of diabetes may be elevated following coronavirus disease 2019 (COVID-19), but it is unclear whether this is specific to severe acute respiratory syndrome coronavirus 2 infection, associated with shared risk factors for severe COVID-19 and diabetes, and/or a generic risk following illness. People admitted to the hospital for COVID-19 ...
Baidal, David A Ballou, Cassandra M Rickels, Michael R Berney, Thierry Pattou, Francois Payne, Elizabeth H Barton, Franca B Alejandro, Rodolfo
Published in
Diabetes care
To determine C-peptide measures and levels associated with positive glycemic control outcomes following islet transplant (ITx) in type 1 diabetes. We evaluated Collaborative Islet Transplant Registry (CITR) islet-alone recipients with pretransplant C-peptide
Petrovski, Goran Campbell, Judith Pasha, Maheen Day, Emma Hussain, Khalid Khalifa, Amel van den Heuvel, Tim
Published in
Diabetes care
We aimed to compare glucose control in adolescents with type 1 diabetes (T1D) using the MiniMed 780G system who used simplified meal announcement with those who used precise carbohydrate counting. This randomized controlled trial included 34 participants (age 12-18 years) with T1D who were on multiple daily injections or insulin pump and were sched...
