Dubourg, Julie Fouqueray, Pascale Thang, Carole Grouin, Jean-Marie Ueki, Kohjiro
Published in
Diabetes care
The aim of this study was to investigate the efficacy and safety of imeglimin, the first in a new class of oral antidiabetic agent, in Japanese patients with type 2 diabetes. This was a double-blind, randomized, parallel-group, placebo-controlled phase 3 trial in 30 sites in Japan. Eligible participants were individuals aged ≥20 years with type 2 d...
Shen, Yun Fan, Xiaohong Zhang, Lei Wang, Yaxin Li, Cheng Lu, Jingyi Zha, Bingbing Wu, Yueyue Chen, Xiaohua Zhou, Jian
...
Published in
Diabetes care
Although elevated glucose levels are reported to be associated with adverse outcomes of coronavirus disease 2019 (COVID-19), the optimal range of glucose in patients with COVID-19 and diabetes remains unknown. This study aimed to investigate the threshold of glycemia and its association with the outcomes of COVID-19. Glucose levels were assessed th...
Blauw, Helga Onvlee, A Joannet Klaassen, Michel van Bon, Arianne C DeVries, J Hans
Published in
Diabetes care
To demonstrate the performance and safety of a bihormonal (insulin and glucagon) artificial pancreas (AP) in adults with type 1 diabetes. In this outpatient, randomized, crossover trial, 2-week fully closed loop glucose control (AP therapy) was compared with 2-week open loop control (patient's normal insulin pump therapy with a glucose sensor if th...
Frias, Juan P Bonora, Enzo Nevarez Ruiz, Luis Li, Ying G Yu, Zhuoxin Milicevic, Zvonko Malik, Raleigh Bethel, M Angelyn Cox, David A
Published in
Diabetes care
To compare efficacy and safety of dulaglutide at doses of 3.0 and 4.5 mg versus 1.5 mg in patients with type 2 diabetes inadequately controlled with metformin. Patients were randomly assigned to once-weekly dulaglutide 1.5 mg, 3.0 mg, or 4.5 mg for 52 weeks. The primary objective was determining superiority of dulaglutide 3.0 mg and/or 4.5 mg over ...
Leese, Graham P Soto-Pedre, Enrique Schofield, Christopher
Published in
Diabetes care
The aim of this study was to compare the University of Texas (UT) and Site, Ischemia, Neuropathy, Bacterial Infection, and Depth (SINBAD) foot ulcer scores in predicting ulcer outcome, within a routine diabetes foot clinic. From 2006 to 2018, data were collected from all patients attending an outpatient diabetes foot clinic with an active ulcer not...
Urbančič-Rovan, Vilma
Published in
Diabetes care
Gou, Wanglong Ling, Chu-Wen He, Yan Jiang, Zengliang Fu, Yuanqing Xu, Fengzhe Miao, Zelei Sun, Ting-Yu Lin, Jie-Sheng Zhu, Hui-Lian
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Published in
Diabetes care
To identify the core gut microbial features associated with type 2 diabetes risk and potential demographic, adiposity, and dietary factors associated with these features. We used an interpretable machine learning framework to identify the type 2 diabetes-related gut microbiome features in the cross-sectional analyses of three Chinese cohorts: one d...
Aigner, Lea Becker, Björn Gerken, Sonja Quast, Daniel R Meier, Juris J Nauck, Michael A
Published in
Diabetes care
Acute experimental variations in glycemia decelerate (hyperglycemia) or accelerate (hypoglycemia) gastric emptying. Whether spontaneous variations in fasting plasma glucose (FPG) have a similar influence on gastric emptying is yet unclear. Gastric emptying of a mixed meal was prospectively studied three times in 20 patients with type 1 diabetes and...
Yang, Aimin Wu, Hongjiang Lau, Eric S H Ma, Ronald C W Kong, Alice P S So, Wing Yee Luk, Andrea O Y Chan, Juliana C N Chow, Elaine
Published in
Diabetes care
There has been a shift toward new classes of glucose-lowering drugs (GLDs) in the past decade but no improvements in glycemic control or hospitalization rates due to severe hypoglycemia (SH) in previous surveys. We examined trends in GLDs use, glycemic control, and SH rate among patients with diabetes in Hong Kong, which introduced a territory-wide...
Echouffo-Tcheugui, Justin B Daya, Natalie Lee, Alexandra K Tang, Olive Ndumele, Chiadi E Windham, B Gwen Shah, Amil M Selvin, Elizabeth
Published in
Diabetes care
To assess the association of severe hypoglycemia measured at baseline with cardiovascular disease (CVD) among community-dwelling older individuals with diabetes, a group particularly susceptible to hypoglycemia. We included older adults with diabetes from the Atherosclerosis Risk in Communities (ARIC) study who attended visit 5 (2011-2013, baseline...
