Azoury, Marie Eliane Tarayrah, Mahmoud Afonso, Georgia Pais, Aurore Colli, Maikel L Maillard, Claire Lavaud, Cassandra Alexandre-Heymann, Laure Gonzalez-Duque, Sergio Verdier, Yann
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Published in
Diabetes
The antigenic peptides processed by β cells and presented through surface HLA Class I molecules are poorly characterized. Each HLA variant, e.g. the most common HLA-A2 and HLA-A3, carries some peptide-binding specificity. Hence, features that, despite these specificities, remain shared across variants may reveal factors favoring β-cell immunogenici...
Huang, Rong Bai, Xinxiu Li, Xueyan Wang, Xiaohui Zhao, Lina
Published in
Diabetes
Pancreatic β cell dysfunction plays a decisive role in progression of type 2 diabetes. Retinol binding protein 4 (RBP4) is a prominent adipokine in type 2 diabetes while its effect on β cell function remains elusive and the underlying mechanisms are unknown. Here, we found that elevated circulating RBP4 levels were inversely correlated with pancrea...
Burns, Christian H Yau, Belinda Rodriguez, Anjelica Triplett, Jenna Maslar, Drew An, You Sun van der Welle, Reini E N Kossina, Ross G Fisher, Max R Strout, Gregory W
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Published in
Diabetes
Insulin secretory granules (SGs) mediate the regulated secretion of insulin, which is essential for glucose homeostasis. The basic machinery responsible for this regulated exocytosis consists of specific proteins present both at the plasma membrane and on insulin SGs. The protein composition of insulin SGs thus dictates their release properties, ye...
Gamblin, Camille Rouault, Christine Lacombe, Amélie Langa-Vives, Francina Farabos, Dominique Lamaziere, Antonin Clément, Karine Gautier, Emmanuel L Yvan-Charvet, Laurent Dugail, Isabelle
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Published in
Diabetes
Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes is unclear. We show that the isolated adipocyte fraction but not the total undigested adipose tissue from obese patients has decreased LAL expression compared to non-obese. Lentiviral-mediated LAL knockd...
Jo, Seokwon Lockridge, Amber Mohan, Ramkumar Esch, Nicholas Schlichting, Regina Panigrahy, Neha Essawy, Ahmad Gustafson, Eric Alejandro, Emilyn U
Published in
Diabetes
Protein translation is essential for cell physiology, and dysregulation of this process has been linked to aging-related diseases such as type 2 diabetes. Reduced protein level of a requisite scaffolding protein of the initiation complex, eIF4G1, downstream of nutrients and insulin signaling, is associated with diabetes in both humans and mice. In ...
Li, Josephine H Szczerbinski, Lukasz Dawed, Adem Y Kaur, Varinderpal Todd, Jennifer N Pearson, Ewan R Florez, Jose C
Published in
Diabetes
There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to anti-diabetes medications. Polygenic scores provide increasing power to detect patterns of disease predisposition that might benefit from a targeted pharmacologic intervention. In the Study to Understand the Genet...
Li, Qian Liu, Xiang Yang, Jimin Erlund, Iris Lernmark, Åke Hagopian, William Rewers, Marian She, Jin-Xiong Toppari, Jorma Ziegler, Anette-G
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Published in
Diabetes
Children's plasma metabolome, especially lipidome reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The TEDDY study enrolled 8676 newborns by screening HLA-DR-DQ genotypes at six clinical centers in four countries; profiled metabolome and measured concentrations of asco...
Tuttle, Katherine R Brosius, Frank C 3rd Cavender, Matthew A Fioretto, Paola Fowler, Kevin J Heerspink, Hiddo J L Manley, Tom McGuire, Darren K Molitch, Mark E Mottl, Amy K
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Published in
Diabetes
Diabetes is the most frequent cause of chronic kidney disease (CKD), leading to nearly half of all cases of kidney failure requiring replacement therapy. The principal cause of death among patients with diabetes and CKD is cardiovascular disease (CVD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors were developed to lower blood glucose levels by...
Gastaldelli, Amalia Ghani, Muhammad Abdul DeFronzo, Ralph A
Published in
Diabetes
With the development of insulin resistance (IR), there is a compensatory increase in the plasma insulin response to offset the defect in insulin action in order to maintain normal glucose tolerance. The insulin response is the result of two factors: insulin secretion and metabolic clearance rate of insulin (MCRI).T2DM subjects (104 NGT, 57 IGT, and...
Jin, Young Ji, Yul Song, Yaechan Choe, Sung Sik Jeon, Yong Geun Na, Heeju Nam, Tae Wook Kim, Hye Jeong Nahmgoong, Hahn Kim, Sung Min
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Published in
Diabetes
Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and related metabolic diseases remains elusive. Here...
