Almby, Kristina E Lundqvist, Martin H Abrahamsson, Niclas Kvernby, Sofia Fahlström, Markus Pereira, Maria J Gingnell, Malin Karlsson, F Anders Fanni, Giovanni Sundbom, Magnus
...
Published in
Diabetes
While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 s...
Bagger, Jonatan I Grøndahl, Magnus F G Lund, Asger Holst, Jens J Vilsbøll, Tina Knop, Filip K
Published in
Diabetes
Hyperglucagonemia is a well-known contributor to diabetic hyperglycemia, and glucagon-like peptide 1 (GLP-1) suppresses glucagon secretion. Reduced inhibitory effects of glucose and GLP-1 on glucagon secretion may contribute to the hyperglucagonemia in diabetes and influence the success of GLP-1 receptor agonist therapy. We examined the dose-respon...
Kim, Kyeezu Joyce, Brian T Zheng, Yinan Schreiner, Pamela J Jacobs, David R Jr Catov, Janet M Shikany, James M Carnethon, Mercedes R Greenland, Philip Van Horn, Linda V
...
Published in
Diabetes
DNA methylation (DNAm)-based biological age (epigenetic age) has been suggested as a useful biomarker of age-related conditions including type 2 diabetes (T2D), and its newest iterations (GrimAge measurements) have shown early promise. In this study, we explored the association between epigenetic age and incident T2D in the context of their relatio...
Firdessa-Fite, Rebuma Johnson, Stephanie N Leon, Martin A Khosravi-Maharlooei, Mohsen Baker, Rocky L Sestak, Joshua O Berkland, Cory Creusot, Remi J
Published in
Diabetes
Antigen-specific immunotherapy (ASIT) offers a targeted treatment of autoimmune diseases that selectively inhibits autoreactive lymphocytes, but there remains an unmet need for approaches that address the limited clinical efficacy of ASIT. Soluble antigen arrays (SAgAs) deliver antigenic peptides or proteins in multivalent form, attached to a hyalu...
Zhao, Shuiling Lo, Chao-Sheng Miyata, Kana N Ghosh, Anindya Zhao, Xin-Ping Chenier, Isabelle Cailhier, Jean-Francois Ethier, Jean Lattouf, Jean-Baptiste Filep, Janos G
...
Published in
Diabetes
We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose, kidney injury, and sodium-glucose cotransporter 2 (Sglt2) expression in diabetic Akita Nrf2 -/-/Nrf2RPTC transgenic (Tg) mice. Immortalized human RPTCs (HK2) stably transfected with plasmid contai...
Nigro, Pasquale Middelbeek, Roeland J W Alves, Christiano R R Rovira-Llopis, Susana Ramachandran, Krithika Rowland, Leslie A Møller, Andreas B Takahashi, Hirokazu Alves-Wagner, Ana B Vamvini, Maria
...
Published in
Diabetes
Recent studies demonstrate that adaptations to white adipose tissue (WAT) are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal WAT (iWAT) in male mice, including decreasing fat mass, improving mitochondrial function, inducing beiging, a...
Qu, Hua Gong, Xiaoli Liu, Xiufei Zhang, Rui Wang, Yuren Huang, Bangliang Zhang, Linlin Zheng, Hongting Zheng, Yi
Published in
Diabetes
Mitochondrial function is essential for bioenergetics, metabolism, and signaling and is compromised in diseases such as proteinuric kidney diseases, contributing to the global burden of kidney failure, cardiovascular morbidity, and death. The key cell type that prevents proteinuria is the terminally differentiated glomerular podocyte. In this study...
Kraft, Guillaume Coate, Katie C Smith, Marta Farmer, Ben Scott, Melanie Cherrington, Alan D Edgerton, Dale S
Published in
Diabetes
Hepatic glucose uptake (HGU) is critical for maintaining normal postprandial glucose metabolism. Insulin is clearly a key regulator of HGU, but the physiologic mechanisms by which it acts have yet to be established. This study sought to determine the mechanisms by which insulin regulates liver glucose uptake under postprandial-like conditions (hype...
Yin, Ye Wu, Yangyang Zhang, Xu Zhu, Yeting Sun, Yue Yu, Jiani Gong, Yufei Sun, Peng Lin, Haiyan Han, Xiao
...
Published in
Diabetes
Downregulation of mitochondrial function in adipose tissue is considered as one important driver for the development of obesity-associated metabolic disorders. Inorganic pyrophosphatase 1 (PPA1) is an enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to inorganic phosphate and is required for anabolism to take place in cells. Although...
Shuai, Lin Li, Bo-Han Jiang, Hao-Wen Yang, Lin Li, Jia Li, Jing-Ya
Published in
Diabetes
Brown and beige adipocytes are characterized as thermogenic adipocytes and have great potential for treating obesity and associated metabolic diseases. In this article, we identify a conserved mammalian lysine 79 of histone H3 (H3K79) methyltransferase, disruptor of telomeric silencing-1 like (DOT1L), as a new epigenetic regulator that controls the...
