Lambert, Arthur W Fiore, Christopher Chutake, Yogesh Verhaar, Elisha R Strasser, Patrick C Chen, Mei Wei Farouq, Daneyal Das, Sunny Li, Xin Eaton, Elinor Ng
...
Published in
Developmental cell
Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs). Isolating pure populations of CSCs is difficult because EMT programs generate multiple alternative cell states, and phenotypic plasticity permits frequent interconversions between thes...
Rhiner, Christa Suzanne, Magali Liu, Guang-Hui Tait, Stephen W G Torii, Keiko U Ichikawa, Takafumi Zhang, Hui Ting Liu, Wen-Cheng Sun, Ning
Published in
Developmental cell
In this selection, we celebrate the art of science by highlighting some of the submitted cover images from the past year. In this collection, our authors share the stories behind their inspiration for how to portray their science to captivate a broader audience. Copyright © 2022 Elsevier Inc. All rights reserved.
Miguel-Aliaga, Irene Vunjak-Novakovic, Gordana Stephenson, Erin J Gachon, Frederic Milagre, Inês Mills, Evanna Rubin, Joshua B Kelava, Iva
Published in
Developmental cell
Researchers are exploring sex differences in experimental models of both development and disease-but are we doing enough? In this collection of Voices, we celebrate researchers who are asking this question and starting to offer mechanistic clues on sexually dimorphic differences seen in interorgan communication, metabolic disease, neurological diso...
Gvozdenovic, Ana Aceto, Nicola
Published in
Developmental cell
Metastatic recurrence develops in 30%-40% of colorectal cancer (CRC) patients in the years that follow surgical removal of the primary tumor. In a recent issue of Nature, Cañellas-Socias et al. identify a distinct population of CRC cells, marked with epithelial membrane protein 1 (EMP1), accountable for metastatic relapse. Copyright © 2022 Elsevier...
Joaquina Delás, M. Kalaitzis, Christos M. Fawzi, Tamara Demuth, Madeleine Zhang, Isabel Stuart, Hannah T. Costantini, Elena Ivanovitch, Kenzo Tanaka, Elly M. Briscoe, James
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Published in
Developmental cell
Graphic abstract
D'Amato, Gaetano Phansalkar, Ragini Naftaly, Jeffrey A Fan, Xiaochen Amir, Zhainib A Rios Coronado, Pamela E Cowley, Dale O Quinn, Kelsey E Sharma, Bikram Caron, Kathleen M
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Published in
Developmental cell
Endocardial cells lining the heart lumen are coronary vessel progenitors during embryogenesis. Re-igniting this developmental process in adults could regenerate blood vessels lost during cardiac injury, but this requires additional knowledge of molecular mechanisms. Here, we use mouse genetics and scRNA-seq to identify regulators of endocardial ang...
Campanale, Joseph P Mondo, James A Montell, Denise J
Published in
Developmental cell
Collective cell movements drive normal development and metastasis. Drosophila border cells move as a cluster of 6-10 cells, where the role of the Rac GTPase in migration was first established. In border cells, as in most migratory cells, Rac stimulates leading-edge protrusion. Upstream Rac regulators in leaders have been identified; however, the re...
Menon, Triveni Burdine, Rebecca D
Published in
Developmental cell
Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right. Copyright © 2022 Elsevier Inc. All rights reserved....
Hazra, Rasmani Brine, Lily Garcia, Libia Benz, Brian Chirathivat, Napon Shen, Michael M Wilkinson, John Erby Lyons, Scott K Spector, David L
Published in
Developmental cell
The mammalian genome encodes thousands of long non-coding RNAs (lncRNAs), many of which are developmentally regulated and differentially expressed across tissues, suggesting their potential roles in cellular differentiation. Despite this expression pattern, little is known about how lncRNAs influence lineage commitment at the molecular level. Here,...
Marie, Kerrie L Merlino, Glenn Day, Chi-Ping
Published in
Developmental cell
Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, includin...
