Gabel, Lisa A. Voss, Kelsey Johnson, Evelyn Lindström, Esther R. Truong, Dongnhu T. Murray, Erin M. Cariño, Karla Nielsen, Christiana M. Paniagua, Steven Gruen, Jeffrey R.
...
Published in
Developmental Neuroscience
Dyslexia is a common learning disability that affects processing of written language despite adequate intelligence and educational background. If learning disabilities remain untreated, a child may experience long-term social and emotional problems, which influence future success in all aspects of their life. Dyslexia has a 60% heritability rate, a...
Wu, Yongmei Huang, Sizhou Zhao, Haixia Cao, Kang Gan, Jinfan Yang, Chan Xu, Zhen Li, Shurong Su, Bingyin
Published in
Developmental Neuroscience
Minichromosome maintenance protein 5 (MCM5), a member of the microchromosomal maintenance protein family, plays an important role in the initiation and extension of DNA replication. However, its role in neural development in zebrafish remains unclear. Here, we used morpholino (MO) and CRISPR/Cas9 to knock down mcm5 and investigated the developmenta...
Mouihate, Abdeslam Kalakh, Samah
Published in
Developmental Neuroscience
Maternal immune activation (MIA) during pregnancy leads to long-lasting effects on brain development and function. Several lines of evidence suggest that the maternal inflammatory cytokine interleukin (IL)-6 plays a crucial role in the long-lasting effects of MIA on adult offspring. IL-6 is naturally produced during pregnancy in the absence of any ...
Pavăl, Denis Micluția, Ioana Valentina
Published in
Developmental Neuroscience
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. Despite intensive research, its etiopathogenesis remains largely unclear. Although studies consistently reported dopaminergic anomalies, a coherent dopaminergic model of ASD was lacking until recently. In 2017...
Levine, Seth M.
Published in
Developmental Neuroscience
Ke, Xingrao Huang, Yingliu Fu, Qi Lane, Robert H. Majnik, Amber
Published in
Developmental Neuroscience
An adverse maternal environment (AME) predisposes adult offspring toward cognitive impairment in humans and mice. However, the underlying mechanisms remain poorly understood. Epigenetic changes in response to environmental exposure may be critical drivers of this change. Epigenetic regulators, including microRNAs, have been shown to affect cognitiv...
Zhang, Lin Levenson, Cathy W. Salazar, Valentina Cea McCarthy, Deirdre M. Biederman, Joseph Zafonte, Ross Bhide, Pradeep G.
Published in
Developmental Neuroscience
Attention deficit hyperactivity disorder (ADHD) increases the risk for concussion or mild traumatic brain injury (mTBI). At the same time, recommendations for the management of ADHD include participation in sports and other organized physical activities, including those that carry an increased risk of mTBI. Very little work has been done to determi...
Li, Zhi Cui, Liangmin Zhao, Hongyao Du, Jinxin Gopinath, Subash C.B. Lakshmipriya, Thangavel Xin, Xuezhi
Published in
Developmental Neuroscience
Objective: Brain-derived neurotrophic factor (BDNF) dysregulation is widely related with various psychiatric and neurological disorders, including schizophrenia, depression, Rett syndrome, and addiction, and the available evidence suggests that BDNF is also highly correlated with Parkinson’s and Alzheimer’s diseases. Methods: The BDNF target sequen...
Huang, Jingyuan Xu, Yan Wang, Fang Wang, Haili Li, Lu Deng, Yanan Cai, Liang
Published in
Developmental Neuroscience
Objective: This study aimed to investigate whether long noncoding RNA sprouty receptor tyrosine kinase signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is involved in the regulation of ketamine-induced neurotoxicity. Methods: Human embryonic stem cells (hESCs) were induced into neurons in vitro and treated with ketamine. Apoptosis and neuri...
Hamada, Nanako Iwamoto, Ikuko Nishikawa, Masashi Nagata, Koh-ichi
Published in
Developmental Neuroscience
MED13L (mediator complex subunit 13-like) is a component of the mediator complex, which functions as a regulator for gene transcription. Since gene abnormalities in MED13L are responsible for neurodevelopmental disorders, MED13L is presumed to play an essential role in brain development. In this study, we prepared a specific antibody against MED13L...
