Hamada, Nanako Noda, Mariko Ito, Hidenori Iwamoto, Ikuko Nagata, Koh-ichi
Published in
Developmental Neuroscience
Centrosomal protein 152 (Cep152) regulates centriole duplication as a molecular scaffold during the cell cycle. Its gene abnormalities are responsible for autosomal recessive primary microcephaly 9 and Seckel syndrome. In this study, we prepared an antibody against mouse Cep152, anti-Cep152, and performed expression analyses focusing on mouse brain...
Zhao, Xiaoyan Shi, Dongjing Du, Yingjie Hu, Chunhua Li, Yun Liu, Jinsheng Pan, Chuxiong
Published in
Developmental Neuroscience
Background: Sevoflurane is a volatile anesthetic that is widely used in pediatric anesthesia due to its low toxicity. However, whether neonatal exposure to sevoflurane induces long-lasting cognitive impairment remains unclear. It has been reported that neuronal injury is the main cause of sevoflurane-induced learning and memory disabilities in the ...
Son, Hae-Won Ali, Declan William
Published in
Developmental Neuroscience
The endocannabinoid system (ECS) is widely studied due to its interactions with cannabis and its role in modulating physiological responses. While most research has focused on the effects of cannabis on adult ECSs, recent studies have begun to investigate the role of the ECS in developing organisms. However, little is known about the spatial or tem...
Muthu, Sakthi Jothi Lakshmanan, Ganesh Seppan, Prakash
Published in
Developmental Neuroscience
Sex steroids are neuromodulators that play a crucial role in learning, memory, and synaptic plasticity, providing circuit flexibility and dynamic functional connectivity in mammals. Previous studies indicate that testosterone is crucial for neuronal functions and required further investigation on various frontiers. However, it is surprising to note...
Barks, Amanda Beeson, Montana M. Hallstrom, Timothy C. Georgieff, Michael K. Tran, Phu V.
Published in
Developmental Neuroscience
Iron deficiency (ID) during neurodevelopment is associated with lasting cognitive and socioemotional deficits and increased risk for neuropsychiatric disease throughout the lifespan. These neurophenotypical changes are underlain by gene dysregulation in the brain that outlasts the period of ID; however, the mechanisms by which ID establishes and ma...
Guo, Shu-Lin Chin, Chih-Hui Huang, Chi-Jung Chien, Chih-Cheng Lee, Yih-Jing
Published in
Developmental Neuroscience
Stem cell-based therapy has been evaluated in many different clinical trials for various diseases. This capability was applied in various neurodegenerative diseases, such as multiple sclerosis, which is characterized by demyelination, axonal injury, and neuronal loss. Dental pulp stem cells (DPSCs) are mesenchymal stem cells from the oral cavity th...
Ramarao, Sumana Pang, Yi Carter, Kathleen Bhatt, Abhay
Published in
Developmental Neuroscience
Oligodendrocyte progenitor cells (OPC) are the primary cellular targets of brain white matter injury (WMI) in very low-birth weight (VLBW) infants. Microglia plays a significant role in inflammation-induced WMI. Our previous study showed that lipopolysaccharide (LPS)-induced OPC damage is mediated by activated microglia in vitro. We hypothesized th...
Nishikawa, Masashi Ito, Hidenori Noda, Mariko Hamada, Nanako Tabata, Hidenori Nagata, Koh-ichi
Published in
Developmental Neuroscience
Rac3 is a member of Rho family small GTPases which regulate cellular signaling and cytoskeletal dynamics. The RAC3 gene abnormalities have been shown to cause neurodevelopmental disorders with structural brain anomalies, including polymicrogyria/dysgyria, callosal abnormalities, brainstem anomalies, and cerebellar dysplasia. Although this evidence ...
Kim, Eunhee Lee, JungSoo Park, Hae-Yeon Lee, Jungjae Kim, Mee-Gang Park, Joo Hyun
Published in
Developmental Neuroscience
As visual perception development proceeds rapidly after birth, early detection of developmental maturity is required. Healthy infants do not have many opportunities for visual perception evaluation, so a reliable evaluation method is necessary. This retrospective study included 276 healthy full-term infants
da Rosa, Naiana de Medeiros, Fabiana Durante de Oliveira, Juliana Laurentino, Ana Olívia Martins Peretti, Eduardo de Medeiros Machado, Richard Simon Lourenço, Millena Pais da Silva, Thatiany Igreja Fernandes, Tamires da Cunha Reis, Patrícia Alves
...
Published in
Developmental Neuroscience
6-Shogaol is one of the main active phenolic components of ginger and has neuroprotective effects by protecting brain against the oxidative stress and regulate the levels of neurotrophic factors. The objective of the present study was to verify the effect of 6-shogaol on neurochemical parameters in offspring after maternal immune activation by lipo...
