Navarro, Maxime Allemang-Trivalle, Aude Leducq, Sophie Jonville-Bera, Annie-Pierre Maurier, Anaïs Zejli, Tarik Edée, Afi-Emiliène Harchaoui, Emilie Giraudeau, Bruno Maruani, Annabel
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Published in
Dermatology
Background: Vascular anomalies (VAs) are increasingly being treated with PI3K/AKT/mTOR pathway inhibitors. These drugs have immunosuppressive properties and thus theoretically overexpose patients to opportunistic infections, especially Pneumocystis jirovecii pneumonia (PJP). PJP prophylaxis use lacks consensus. We aimed to investigate the prevalenc...
Ramelyte, Egle Welti, Michèle Gardin, Fabian Maul, Julia-Tatjana Dummer, Reinhard Imhof, Laurence
Published in
Dermatology
Introduction: Keloid is an abnormal proliferation of scar tissue that grows beyond the original margins of the injury. Even after complete resection, recurrences are common and pose a poorly understood challenge in dermatology. There is lack of large prospective clinical trials; thus, treatment recommendations are based on retrospective analyses an...
Caldarola, Giacomo De Luca, Eleonora Barini, Angelina Basile, Umberto Carnazzo, Valeria Chiricozzi, Andrea Tolusso, Barbara Gremese, Elisa Di Nardo, Lucia Peris, Ketty
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Published in
Dermatology
Introduction: Night shift work disrupts circadian rhythms and has been associated with immune system alterations and various health conditions. However, there is limited data regarding its impact on psoriasis. The aim of our study was to compare psoriasis severity and the hormonal and immunological profile in patients with a night shift work to tho...
Ubago-Rodríguez, Ana Quiñones-Vico, María I. Sánchez-Díaz, Manuel Sanabria-de la Torre, Raquel Sierra-Sánchez, Álvaro Montero-Vílchez, Trinidad Fernández-González, Ana Arias-Santiago, Salvador
Published in
Dermatology
Introduction: Psoriasis is a chronic inflammatory skin disease with variable clinical presentation, multifactorial etiology and an immunogenetic basis. Several studies demonstrate that it results from a dysregulated interaction between skin keratinocytes, immune cells, and the environment that leads to a persistent inflammatory process modulated by...
deCampos-Stairiker, Mallory Kody, Shannon Meyers, Gabrielle Maxson, Julia Ortega-Loayza, Alex G.
Published in
Dermatology
Introduction: Neutrophilic dermatoses (NDs) often occur secondary to inflammatory conditions, medication exposure, and hematologic malignancy. While malignancy-associated NDs (MA-NDs) have been well reported among those with hematologic cancers, little is known about drug-induced NDs (DI-NDs) within this population. The objective of this study was ...
Weissmann, Sarah Babyev, Amit Shira Gordon, Michal Golan-Tripto, Inbal Horev, Amir
Published in
Dermatology
Introduction: Atopic dermatitis (AD) is a common chronic skin disease with an inflammatory pathophysiology that includes the activation of the innate and adaptive immune systems. We aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and eosinophil-to-neutrophil ra...
Hu, Yu-Qing Zhang, Jian-Zhong Zhao, Yan
Published in
Dermatology
Introduction: With the aging of the population in China, the prevalence of atopic dermatitis (AD) is high in elderly patients. These patients usually have more comorbidities and they need more effective and safer treatments. Dupilumab is an anti-interleukin-4 (IL-4) receptor monoclonal antibody which was approved for the treatment of moderate-to-se...
Friedland, Rivka Glick, Mirit Amitay-Laish, Iris Toledano, Helen
Published in
Dermatology
Introduction: Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are in use for several indications for adults and children. Cutaneous toxicities are among the most common adverse effects. We aimed to describe the spectrum of cutaneous adverse events, its frequency, and severity in a cohort of pediatric patients. Methods: We r...
Lim, Sophie Soyeon Lee, Ji Su Ju, Hyun Jeong Bae, Jung Min Jo, Seong Jin Mun, Je-Ho
Published in
Dermatology
Wu, Kejia Wang, Wanrong Cheng, Qianhui Xiao, Duncheng Li, Yunxiao Chen, Mengyun Zheng, Xiaodong
Published in
Dermatology
Introduction: According to the common disease/rare variant hypothesis, it is important to study the role of rare variants in complex diseases. The association of rare variants with psoriasis has been demonstrated, but the association between rare variants and specific clinical subtypes of psoriasis has not been investigated. Methods: Gene-based and...
