Kaufman-Janette, Joely Joseph, John H. Kaminer, Michael S. Clark, James Fabi, Sabrina G. Gold, Michael H. Goldman, Mitchel P. Katz, Bruce E. Peddy, Kappa Schlessinger, Joel
...
Published in
Dermatologic Surgery
Fibrous septae play a role in contour alterations associated with cellulite. OBJECTIVE To assess collagenase clostridium histolyticum-aaes (CCH) for the treatment of cellulite. MATERIALS AND METHODS Two identically designed phase 3, double-blind, randomized studies (RELEASE-1 and RELEASE-2) were conducted. Adult women with moderate/severe cellulite...
Faivre, Jimmy Gallet, Mélanie Tremblais, Elodie Trévidic, Patrick Bourdon, François
Published in
Dermatologic Surgery
Crosslinked hyaluronic acid (HA)-based soft tissue fillers possess unique viscoelastic properties intended to match specific product indications. Manufacturing has an impact on HA chain integrity and on filler properties. OBJECTIVE This study introduces 2 new rheological parameters to evaluate the macroscopic characteristics of fillers. METHODS AND...
Cohen, Joel L. Green, Lawrence J. Beer, Kenneth R. Liu, Yan Gallagher, Conor J.
Published in
Dermatologic Surgery
Pivotal studies of approved botulinum toxin type A (BoNTA) formulations for treatment of glabellar lines have mostly included treatment-naive participants, and the impact of prior BoNTA treatment on efficacy and safety is not well documented. OBJECTIVE To evaluate whether prior BoNTA treatment affects efficacy, duration of response, and tolerabilit...
Weiss, Robert Beer, Kenneth Cox, Sue E. Palm, Melanie Kaufman-Janette, Joely Bassichis, Benjamin Biesman, Brian Joseph, John Almegård, Birgitta Nilsson, Anna
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Published in
Dermatologic Surgery
HARK was recently approved in the US for lip augmentation and correction of upper perioral rhytids. OBJECTIVE To demonstrate noninferiority of HARK versus a control (HAJV) in lip fullness augmentation at Week 8 after last injection (blinded evaluation). Secondary objectives were to evaluate the effectiveness and safety of HARK in lip fullness augme...
Nikolis, Andreas Bertucci, Vince Solish, Nowell Lane, Vanessa Nogueira, Alessandra
Published in
Dermatologic Surgery
HARK is an FDA-approved flexible filler designed for lips. OBJECTIVE To quantitatively evaluate subject outcomes by measuring the change in lip texture, color (redness), lip fullness, and lip and perioral surface stretch (dynamic strain) after treatment. METHODS AND MATERIALS In this 8-week open-label, Phase IV multicenter study, subjects were trea...
Kwak, Seongsung Kang, Won-Ho Rhee, Chang-Hoon Yang, Gi-Hyeok Cruz, Deu John M
Published in
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
A new complexing protein-free botulinum toxin Type A (CBoNT) with the same mechanism of action as the botulinum toxin complex onabotulinumtoxinA (OBoNT) and complexing protein-free incobotulinumtoxinA (IBoNT) was recently developed. To compare the local paresis and chemodenervation efficacy of 3 different botulinum toxin Type A preparations in mice...
Schlessinger, Joel Cohen, Joel L. Shamban, Ava Jacob, Carolyn Karimi, Kian Maas, Corey Lane, Vanessa Coquis-Knezek, Sarah Meckfessel, Matthew
Published in
Dermatologic Surgery
Real-world re-treatment intervals for botulinum toxins vary, but most subjects receive treatment less frequently than the manufacturer-recommended minimum intervals. In subjects receiving treatment with AbobotulinumtoxinA (ABO) less frequently, high levels of satisfaction and psychosocial improvements in well-being, self-confidence, and quality of ...
Taylor, Susan C. Grimes, Pearl E. Joseph, John H. Jonker, Anneke Avelar, Rui L.
Published in
Dermatologic Surgery
BACKGROUND Limited US clinical data are available on the use of aesthetic products in patients with skin of color (SOC). OBJECTIVE To compare the efficacy and safety of prabotulinumtoxinA for the treatment of glabellar lines in patients with and without SOC. METHODS AND MATERIALS Post hoc analyses were performed on the pooled population of all 492 ...
Koh, Yun Pei Tan, Aaron Wei Min Chua, Sze Hon
Published in
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Picosecond lasers have become very popular in the treatment of hyperpigmentation. Evaluating the efficacy and safety of picosecond 755-nm laser in treatment of nevi of Ota (NO) and Hori's nevi (HN) in Asians with Fitzpatrick skin Types III/IV. A retrospective review of patient records at the National Skin Center, Singapore, from 2015 to 2017. Three...
Cohen, Joel L. Sadick, Neil S. Kirby, M. Todd McLane, Michael P. Lenderking, William R. Bender, Randall H. Chen, Jun Hurley, David Knoble, Naomi B. Liu, Genzhou
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Published in
Dermatologic Surgery
The Clinician Reported Photonumeric Cellulite Severity Scale (CR-PCSS) and Patient Reported PCSS (PR-PCSS) are newly developed tools for assessing cellulite severity. OBJECTIVE To report on the reliability, validity, and ability to detect a change in cellulite severity on the buttocks of adult women with the CR-PCSS and PR-PCSS. MATERIALS AND METHO...
