Perlis, Roy H Dowd, Daniel Fava, Maurizio Lencz, Todd Krause, David S
Published in
Depression and anxiety
Cohort and cost-effectiveness studies suggest that measuring variation in genes that influence metabolism of common drugs could improve antidepressant treatment outcomes. Prior randomized trials have yielded inconsistent results. Multicenter randomized double-blind (subject and rater), controlled trial of pharmacogenomic testing among outpatients w...
Pegg, Samantha Dickey, Lindsay Green, Haley Kujawa, Autumn
Published in
Depression and anxiety
Suicidality in youth is a major public health problem and objective methods for identifying those at greatest risk are critically needed. Suicidality has been associated with alterations in reward-related decision-making, but the extent to which measures of reward responsiveness (RR) can differentiate youth with and without suicidality in clinical ...
Peter, Raphael S Meyer, Michelle L Mons, Ute Schöttker, Ben Keller, Ferdinand Schmucker, Roman Koenig, Wolfgang Brenner, Hermann Rothenbacher, Dietrich
Published in
Depression and anxiety
Anxiety and depression seem to be under-recognized in their importance and are often not incorporated in subsequent prevention strategies in routine clinical care of coronary heart disease. The KAROLA cohort included coronary heart disease patients participating in an in-patient rehabilitation program (years 1999/2000) and followed after 1, 3, 6, 8...
Sinopoli, Vanessa M Erdman, Lauren Burton, Christie L Park, Laura S Dupuis, Annie Shan, Janet Goodale, Tara Shaheen, S-M Crosbie, Jennifer Schachar, Russell J
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Published in
Depression and anxiety
Hoarding, originally only considered a symptom of obsessive-compulsive disorder (OCD), is now categorized as a separate disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). We studied candidate serotonergic genes and the distinctness of hoarding in children and adolescents and hypothesized that unique ...
Medeiros, Gustavo C Rush, A John Jha, Manish Carmody, Thomas Furman, Jennifer L Czysz, Andrew H Trombello, Joseph M Cooper, Crystal M Trivedi, Madhukar H
Published in
Depression and anxiety
Heterogeneity in major depressive disorder (MDD) is well recognized but not well understood. Core depressive features are reward and emotional symptoms, which reflect dysfunctions in the positive valence (PV) and negative valence (NV) systems, respectively. This study assessed whether PV and NV systems (based on selected symptoms) were associated w...
Weissman, David G. Lambert, Hilary K. Rodman, Alexandra M. Peverill, Matthew Sheridan, Margaret A. McLaughlin, Katie A.
Published in
Depression and anxiety
Background: Stressful life events are more likely to trigger depression among individuals exposed to childhood adversity. However, the mechanisms underlying this stress sensitization remain largely unknown. Any such mechanism must be altered by childhood adversity and interact with recent stressful life events, magnifying their association with dep...
Bonanno, George A Malgaroli, Matteo
Published in
Depression and anxiety
Diagnostic criteria for prolonged grief have appeared in the Diagnostic and Statistical Manual of Mental Disorders ( DSM-5; persistent complex bereavement disorder, PCBD) and in the ICD-11 (prolonged grief disorder, PGD), and the question of which diagnosis is most clinically useful has been hotly debated. This study provides the first longitudinal...
Djelantik, A A A Manik J Robinaugh, Donald J Kleber, Rolf J Smid, Geert E Boelen, Paul A
Published in
Depression and anxiety
Although bereavement is likely a common stressor among patients referred to a psychotrauma clinic, no study has yet examined the co-occurrence and relationships between symptoms of prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and major depressive disorder symptoms in this population. In a sample of patients seeking treatmen...
Simon, Naomi M Hoeppner, Susanne S Lubin, Rebecca E Robinaugh, Donald J Malgaroli, Matteo Norman, Sonya B Acierno, Ron Goetter, Elizabeth M Hellberg, Samantha N Charney, Meredith E
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Published in
Depression and anxiety
Complicated grief (CG) is a bereavement-specific syndrome distinct from but commonly comorbid with posttraumatic stress disorder (PTSD). While bereavement is common among military personnel (Simon et al., 2018), there is little research on the impact of CG comorbidity on PTSD treatment outcomes. To evaluate the impact of comorbid CG on PTSD treatme...
Lenferink, Lonneke I M Nickerson, Angela de Keijser, Jos Smid, Geert E Boelen, Paul A
Published in
Depression and anxiety
Previous latent trajectory studies in adult bereaved people have identified individual differences in reactions postloss. However, prior findings may not reflect the complete picture of distress postloss, because they were focused on depression symptoms following nonviolent death. We examined trajectories of symptom-levels of persistent complex ber...
