Xu, Huijing Gong, Yushuang Jiao, Yang Guo, Jian Zhao, Ling Yang, Juechen Tong, Haibin Sun, Meiyan Li, Miao
Published in
Current pharmaceutical design
Neuromyelitis optica (NMO) is a severe neurological demyelinating autoimmune disease affecting the optic nerves and spinal cord. The binding of neuromyelitis optica immunoglobulin G (NMO-IgG) and aquaporin-4 (AQP4) on the surface of astrocytes in the serum and cerebrospinal fluid is the main pathogenesis of NMO. Currently, therapeutic strategies fo...
Shahab, Muhammad Liang, Chaoqun Duan, Xiuyuan Zheng, Guojun Wadood, Abdul
Published in
Current pharmaceutical design
Cancer is recognized globally as the second-most dominating and leading cause of morbidities. Breast cancer is the most often diagnosed disease in women and one of the leading causes of cancer mortality. In women, 287,850, and in males, 2710 cases were reported in 2022. Approximately 10-20% of all new cases of breast cancer diagnosed in the United ...
Fang, Wen-Lai Lv, Yi-Yun Jin, Shu-Qing Zhu, Zheng Chen, Yun-Zhen
Published in
Current pharmaceutical design
Diabetic osteoporosis (DOP) has gradually gained public attention. The clinical manifestations of DOP include bone mass loss, bone microstructural damage, and increased bone fragility. Intracellular reactive oxygen species (ROS) production was significantly increased under high glucose (HG) conditions, with deleterious effects on bone mesenchymal s...
Butter, Christian Seifert, Martin Georgi, Christian Iliodromitis, Konstantinos Bogossian, Harilaos
Published in
Current pharmaceutical design
Cardiac resynchronization therapy (CRT) is the therapy of choice for patients with symptomatic systolic heart failure (HF) and left bundle branch block (LBBB), despite optimal medical therapy (OMT). The recently published 2021 European Society of Cardiology (ESC) Guidelines on cardiac pacing and cardiac resynchronization therapy highlight the impor...
Magdy, Galal Elmansi, Heba Belal, Fathalla El-Deen, Asmaa Kamal
Published in
Current pharmaceutical design
Carbon dots (CDs) have recently attracted attention as a new class of photoluminescent materials with promising optical, chemical, and electrical properties. They have been proposed for various applications, such as pharmaceutical sensing, biomarker detection, and cellular bioimaging, by virtue of their economical synthesis, cheap starting material...
Rizzo, Manfredi
Published in
Current pharmaceutical design
Li, Tengfei Li, Fengzhen Cha, Xudong Wang, Shenglei Yan, Jianyu Wang, Tianyu Liang, Caiquan Zhuang, Chunlin Ren, Wenwen Liu, Huanhai
...
Published in
Current pharmaceutical design
We aimed to evaluate the effectiveness of topical tranexamic acid (TXA) versus topical vasoconstrictors in the management of epistaxis via a systematic review and meta-analysis. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were followed for the meta-analysis. We systematically searched Embase, Web of Sci...
Cannataro, Roberto Cione, Erika
Published in
Current pharmaceutical design
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 20 to 25 nucleotides, present in all body fluids; they can be used as biomarkers, but much more than this as a therapy to replace missing protein or to downregulate excess or aberrant synthesis; here we report possible insight to future studies, needed in this exciting...
Sousa, Ana Sofia Araújo-Rodrigues, Helena Pintado, Manuela Estevez
Published in
Current pharmaceutical design
Edible mushrooms have been classified as "next-generation food" due to their high nutritional value coupled with their biological and functional potential. The most extensively studied and reported mushroom macromolecules are polysaccharides. However, macrofungi proteins and peptides are also a representative and significant bioactive group. Severa...
Moya Moreira, Thaysa Fernandes Gonçalves, Odinei Hess Leimann, Fernanda Vitória Ribeiro, Ricardo Pereira
Published in
Current pharmaceutical design
Fish protein hydrolysates (FPHs) can be obtained from substrates such as fish muscle, skin, and wastes and assign value to these fish by-products. Proteolytic enzymes catalyze the hydrolysis of these fish substrates' peptide bonds resulting in smaller peptides that present several bioactive properties. Hydrolysates' bioactive properties are a funct...
