Birnie, Anthony Plat, Audrey Korkmaz, Cemil Bothma, Jacques P
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Current biology : CB
The genes that drive development each typically have many different enhancers. Properly coordinating the action of these different enhancers is crucial to correctly specifying cell-fate decisions, yet it remains poorly understood how their activity is choregraphed in time. To shed light on this question, we used recently developed single-cell live ...
Lutton, Judith E. Coker, Helena L.E. Paschke, Peggy Munn, Christopher J. King, Jason S. Bretschneider, Till Kay, Robert R.
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Current biology : CB
Macropinocytosis is a conserved endocytic process by which cells engulf droplets of medium into micron-sized vesicles. We use light-sheet microscopy to define an underlying set of principles by which macropinocytic cups are shaped and closed in Dictyostelium amoebae. Cups form around domains of PIP3 stretching almost to their lip and are supported ...
Ganguli, Sushila Wyatt, Tom Nyga, Agata Lawson, Rachel H. Meyer, Tim Baum, Buzz Matthews, Helen K.
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Current biology : CB
Graphic abstract
Yao, Yilong Chen, Jingwen Li, Xingyu Chen, Zhou-Feng Li, Peng
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Current biology : CB
Increased ventilation is a critical process that occurs when the body responds to a hypoxic environment. Sighs are long, deep breaths that prevent alveolar collapse, and their frequency is significantly increased by hypoxia. In this study, we first show that sighing is induced by hypoxia as a function of increased hypoxic severity and that hypoxia-...
Hidalgo, Sergio Anguiano, Maribel Tabuloc, Christine A Chiu, Joanna C
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Current biology : CB
Organisms adapt to seasonal changes in photoperiod and temperature to survive; however, the mechanisms by which these signals are integrated in the brain to alter seasonal biology are poorly understood. We previously reported that EYES ABSENT (EYA) shows higher levels in cold temperature or short photoperiod and promotes winter physiology in Drosop...
Arnal, Luc H Flinker, Adeen Kleinschmidt, Andreas Giraud, Anne-Lise Poeppel, David
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Screaming is arguably one of the most relevant communication signals for survival in humans. Despite their practical relevance and their theoretical significance as innate [1] and virtually universal [2, 3] vocalizations, what makes screams a unique signal and how they are processed is not known. Here, we use acoustic analyses, psychophysical exper...
Pardo-Garcia, Thibaut R Gu, Kathleen Woerner, Riley K R Dus, Monica
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Current biology : CB
In mammals, learning circuits play an essential role in energy balance by creating associations between sensory cues and the rewarding qualities of food. This process is altered by diet-induced obesity, but the causes and mechanisms are poorly understood. Here, we exploited the relative simplicity and wealth of knowledge about the D. melanogaster r...
Warecki, Brandt Bast, Ian Tajima, Matthew Sullivan, William
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Current biology : CB
The complete separation of sister chromatids during anaphase is a fundamental requirement for successful mitosis. Therefore, divisions with either persistent DNA-based connections or lagging chromosome fragments threaten aneuploidy if unresolved. Here, we demonstrate the existence of an anaphase mechanism in normally dividing cells in which pervasi...
Whiteman, Noah
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Current biology : CB
Interview with Noah Whiteman, who studies adaptations that arise from species interactions. Copyright © 2022.
Gowda, Karna Kuehn, Seppe
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Current biology : CB
The molecules of life can be double-edged, performing both beneficial and detrimental roles depending on the environmental context. New work reveals how the Jekyll and Hyde nature of nitric oxide shapes complexity in microbial biofilms, from ecological interactions to spatial structure. Copyright © 2022 Elsevier Inc. All rights reserved.
