In-silico Subtractive Proteomic Analysis Approach for Therapeutic Targets in MDR Salmonella enterica subsp. enterica ser...
Published in Current Topics in Medicinal Chemistry
Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?
Published in Current Topics in Medicinal Chemistry
A majority of cancers display alterations in epigenetic mechanisms, such as aberrant DNA methylation at CpG islands (CGIs). This local hypermethy-lation of CGIs is associated with gene silencing leading to loss of tumor sup-pressor gene (TSG) functions that are critical for the control of tumor devel-opment. Concomitantly, global genomic hypomethyl...
Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments
Published in Current Topics in Medicinal Chemistry
Despite considerable scientific progress, the burden of cancer in our society remains a major public health problem. Tumorigenesis is recognized as a complex and multistep process that involves the accumulation of successive transformational events with multi-factorial etiology. Nevertheless, such events result in the acquisition of key hallmark ch...
Role of Histone Acetylation in Cell Cycle Regulation
Published in Current Topics in Medicinal Chemistry
Core histone acetylation is a key prerequisite for chromatin decondensation and plays a pivotal role in regulation of chromatin structure, function and dynamics. The addition of acetyl groups disturbs histone/DNA interactions in the nucleosome and alters histone/histone interactions in the same or adjacent nucleosomes. Acetyl groups can also provid...
Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic...
Published in Current Topics in Medicinal Chemistry
Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives
...Published in Current Topics in Medicinal Chemistry
The influence of the length of the first metatarsal on the risk of reulceration in the feet of patients with diabetes.
Published in Current Topics in Medicinal Chemistry
Our aim was to identify the optimal diagnostic cutoff point on the scale of protrusion measurements of the first metatarsal (M1) to predict the probability of reulceration after metatarsal head resection in patients with diabetes mellitus. We conducted a prospective study of patients with diabetes who underwent resection of at least 1 metatarsal he...
Database construction and peptide identification strategies for proteogenomic studies on sequenced genomes
Published in Current Topics in Medicinal Chemistry
Since the advent of high-throughput DNA sequencing technologies, the ever-increasing rate at which genomes have been published has generated new challenges notably at the level of genome annotation. Even if gene predictors and annotation softwares are more and more efficient, the ultimate validation is still in the observation of predicted gene pro...
From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors
Published in Current Topics in Medicinal Chemistry
TNF-α was discovered more then 20 years ago as a cytokine implicated in a wide range of cell signaling pathways, many of which are known to lead to the activation of genes involved in inflammation and carcinogenesis. TNF-α is involved in the pathogenesis of many diseases, including Crohn's disease, diabetes, septic shock, tumorigenesis, rheumatoid ...
Pharmacology of CCKRs and SAR studies of peptidic analog ligands.
Published in Current Topics in Medicinal Chemistry
Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract but also found in high density in the mammalian brain. The C-terminal sulphated octapeptide fragment of cholecystokinin (CCK(8)) constitutes one of the major neuropeptides in the brain. CCK8, interacting with nanomolar affinities with two different receptors desi...
