In-silico Subtractive Proteomic Analysis Approach for Therapeutic Targets in MDR Salmonella enterica subsp. enterica ser...
Published in Current Topics in Medicinal Chemistry
Targeting the PAC1 Receptor for Neurological and Metabolic Disorders
Published in Current Topics in Medicinal Chemistry
The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1 ) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral nervous systems. The activation of PAC1R initiates...
Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication
Published in Current Topics in Medicinal Chemistry
The history of the human immunodeficiency virus (HIV)/AIDS therapy, which spans over 30 years, is one of the most dramatic stories of science and medicine leading to the treatment of a disease. Since the advent of the first AIDS drug, AZT or zidovudine, a number of agents acting on different drug targets, such as HIV enzymes ( e.g. reverse transcri...
Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends
Published in Current Topics in Medicinal Chemistry
Toxoplasmosis and neosporosis are closely related protozoan diseases that lead to important economic impacts in farm ruminants. Toxoplasma gondii infection mainly causes reproductive failure in small ruminants and is a widespread zoonosis, whereas Neospora caninum infection is one of the most important causes of abortion in cattle worldwide. Vaccin...
Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?
Published in Current Topics in Medicinal Chemistry
A majority of cancers display alterations in epigenetic mechanisms, such as aberrant DNA methylation at CpG islands (CGIs). This local hypermethy-lation of CGIs is associated with gene silencing leading to loss of tumor sup-pressor gene (TSG) functions that are critical for the control of tumor devel-opment. Concomitantly, global genomic hypomethyl...
Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments
Published in Current Topics in Medicinal Chemistry
Despite considerable scientific progress, the burden of cancer in our society remains a major public health problem. Tumorigenesis is recognized as a complex and multistep process that involves the accumulation of successive transformational events with multi-factorial etiology. Nevertheless, such events result in the acquisition of key hallmark ch...
Role of Histone Acetylation in Cell Cycle Regulation
Published in Current Topics in Medicinal Chemistry
Core histone acetylation is a key prerequisite for chromatin decondensation and plays a pivotal role in regulation of chromatin structure, function and dynamics. The addition of acetyl groups disturbs histone/DNA interactions in the nucleosome and alters histone/histone interactions in the same or adjacent nucleosomes. Acetyl groups can also provid...
Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic...
Published in Current Topics in Medicinal Chemistry
Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives
...Published in Current Topics in Medicinal Chemistry
The influence of the length of the first metatarsal on the risk of reulceration in the feet of patients with diabetes.
Published in Current Topics in Medicinal Chemistry
Our aim was to identify the optimal diagnostic cutoff point on the scale of protrusion measurements of the first metatarsal (M1) to predict the probability of reulceration after metatarsal head resection in patients with diabetes mellitus. We conducted a prospective study of patients with diabetes who underwent resection of at least 1 metatarsal he...
