Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
de Joussineau, Cyrille Bataillé, Laetitia Jagla, Teresa Jagla, Krzysztof
Published in
Current Topics in Developmental Biology
Understanding gene regulatory pathways underlying diversification of cell types during development is one of the major challenges in developmental biology. Progressive specification of mesodermal lineages that are at the origin of body wall muscles in Drosophila embryos has been extensively studied during past years, providing an attractive framewo...
Kopan, Raphael Chen, Shuang Little, Melissa
Published in
Current Topics in Developmental Biology
Within the developing mammalian kidney, several populations of progenitors form the discrete cellular components of the final organ. Fate mapping experiments revealed the cap mesenchyme (CM) to be the progenitor population for all nephron epithelial cells, whereas the neighboring stromal mesenchyme gives rise to mesangial, pericytic, renin-producin...
Robb, Sofia M.C. Alvarado, Alejandro Sánchez
Published in
Current Topics in Developmental Biology
The freshwater planarian Schmidtea mediterranea has emerged as a powerful model system for studying regeneration and adult stem cell (ASC) biology. This is largely due to the developmental plasticity of these organisms and the abundant distribution and experimental accessibility of their ASCs. Techniques such as whole mount in situ hybridization, d...
Shin, Soona Kaestner, Klaus H.
Published in
Current Topics in Developmental Biology
The liver plays an essential role in glucose and lipid metabolism, synthesis of plasma proteins, and detoxification of xenobiotics and other toxins. Chronic disease of this important organ is one of the leading causes of death in the United States. Following loss of tissue, liver mass can be restored by two mechanisms. Under normal conditions, or a...
Leeman, Kristen T. Fillmore, Christine M. Kim, Carla F.
Published in
Current Topics in Developmental Biology
The mammalian lung is a complex organ containing numerous putative stem/progenitor cell populations that contribute to region-specific tissue homeostasis and repair. In this review, we discuss recent advances in identifying and studying these cell populations in the context of lung homeostasis and disease. Genetically engineered mice now allow for ...
Yang, Qi-En Oatley, Jon M.
Published in
Current Topics in Developmental Biology
Sperm have a vital role in the continuity of a species by contributing genetic information to the next generation. Production of these specialized gametes in numbers sufficient to confer normal fertility occurs via cycling of the spermatogenic lineage, a process referred to as spermatogenesis. Continuity relies on the activities of a self-renewing ...
Published in
Current Topics in Developmental Biology
Tadeu, Ana Mafalda Baptista Horsley, Valerie
Published in
Current Topics in Developmental Biology
The skin is the first line of defense against dehydration and external environmental aggressions. It constantly renews itself throughout adult life mainly due to the activity of tissue-specific stem cells. In this review, we discuss fundamental characteristics of different stem cell populations within the skin and how they are able to contribute to...
Published in
Current Topics in Developmental Biology
