Luong, Thu-Lan T. Powers, Chelsea N. Reinhardt, Brian J. Weina, Peter J.
Published in
Current Research in Pharmacology and Drug Discovery
• In vitro hepatocytes assays can predict relevant drug-drug interactions (DDIs). • Proof-of concept data testing can provide a clear insight of multidrug regimen DDIs. • Classifying drugs as inhibitors/inducers alone cannot successfully identify DDIs. • Regimens requiring three or more drugs may cause significant DDIs (p-value
Gore, Manish Tiwari, Ankit Jahagirdar, Devashree Narayanasamy, Angayarkanni Jain, Ratnesh Dandekar, Prajakta
Published in
Current Research in Pharmacology and Drug Discovery
• Matrix-free three-dimensional RF/6A spheroids were developed and characterized. • VEGF-induced sprouting in RF/6A spheroids mimicked in-vivo vascular angiogenesis. • Bevacizumab showed clinically-relevant anti-angiogenic responses in spheroid model. • Proof-of-concept for in-vitro diabetic retinopathy model was developed.
Duarte, Diana Vale, Nuno
Published in
Current Research in Pharmacology and Drug Discovery
• Drug combination aims to achieve positive combination interaction effects. • The available reference models have different mathematical frameworks. • To date, there is not a standard reference model to evaluate synergism. • Reference models must be adequate to the available data and type of study. • Synergism in clinical trials is usually support...
Bansal, Preeti Singh, Naresh Joshi, Jayadev Arora, Naveen Gaur, Shailendera N
Published in
Current research in pharmacology and drug discovery
Allergic airway disease manifestation is induced by lysophosphatidylcholine (LPC) through CD1d-restricted Natural killer T (NKT) cells. Choline chloride (ChCl) and LPC both have the "choline" moiety in their structure and this may interplay the effect in allergic airway disease pathway. To test the hypothesis, mice were sensitized with cockroach ex...
Moreira Castro, Brenda Fernanda Nunes da Silva, Carolina Barbosa Cordeiro, Lídia Pereira Pereira de Freitas Cenachi, Sarah Vasconcelos-Santos, Daniel Vitor Machado, Renes Resende Dias Heneine, Luiz Guilherme Silva, Luciana Maria Silva-Cunha, Armando Fialho, Silvia Ligório
...
Published in
Current Research in Pharmacology and Drug Discovery
• Melittin at low concentration is safe for intravitreal administration. • The antiangiogenic effect of melittin on the chorioallantoic membrane model is comparable to bevacizumab. • Melittin protects retinal cells from inflammatory response induced by lipopolysaccharide. • Melittin improves clinical, functional and morphological signs of inflammat...
Dhote, Vipin Mandloi, Avinash Singh Singour, Pradeep Kumar Kawadkar, Manisha Ganeshpurkar, Aditya Jadhav, Manoj P.
Published in
Current Research in Pharmacology and Drug Discovery
• Molecular docking study. • Drug repurposing. • Combinatorial approach. • Network Pharmacology.
Akefe, Isaac Oluwatobi Adegoke, Victoria Aderonke Lamidi, Ibrahim Yusuf Ameh, Matthew Phillip Idoga, Enokela Shaibu Ubah, Simon Azubuike Ajayi, Itopa Etudaye
Published in
Current Research in Pharmacology and Drug Discovery
• Data from the present study demonstrates that the administration of streptozotocin impairs spatial memory in mice and induces alterations in markers of oxido-inflammatory response, cholinergic function, histoarchitecture, and neurotransmitter levels in the hippocampus. • The administration of myrtenal enhances spatial memory performance in strept...
Ressaissi, Asma Serralheiro, Maria Luísa M.
Published in
Current Research in Pharmacology and Drug Discovery
• Hydroxycinnamic acid derivatives and ezetimibe permeated the intestinal barrier. • Hydroxycinnamic acid derivatives decreased cholesterol permeability. • Hydroxycinnamic acid derivatives could affect the cell components. • PCA of FTIR spectra showed differences on protein and nucleic acid regions.
Joharapurkar, Amit A. Patel, Vishal J. Kshirsagar, Samadhan G. Patel, Maulik S. Savsani, Hardikkumar H. Kajavadara, Chetan Valani, Darshan Jain, Mukul R.
Published in
Current Research in Pharmacology and Drug Discovery
• Prolyl hydroxylase inhibitor desidustat reduces rhEPO requirement in anemia. • Desidustat maintains normal haemoglobin after discontinuation of rhEPO treatment. • The drug increases erythropoiesis by increasing endogenous EPO and reducing EPO-resistance. • It also enhances erythroid maturation by suppressing hepcidin-ferroportin axis. • Desidusta...
Kumar, Krishan Rani, Varsha Mishra, Mohini Chawla, Ruchi
Published in
Current Research in Pharmacology and Drug Discovery
• Chemotherapeutic drugs in combination with siRNAs. • Overcoming multidrug resistance using the combinatorial approach. • Use of Combinatorial therapy to promote apoptosis. • Extracellular barriers to RNAi mediated siRNA therapy. • Nanocarrier chemotherapeutics-siRNA co-delivery system.
