Chen, Shibin Xie, Qiujie Yang, Ming Shi, Yajun Shi, Junhui Zeng, Xiaobin
Published in
Current pharmaceutical biotechnology
Baicalin, a flavonoid glycoside compound present in Scutellaria baicalensis, has shown a wide spectrum of biological activities, but its liposolubility, water-solubility and mucosal permeability are all very poor, which leads to the low concentration in brain and poor bioavailability by oral or intravenous injective administration. The primary obje...
Januszyk, Krzysztof Januszyk, Piotr Grabarek, Beniamin O Boroñ, Dariusz Oplawski, Marcin
Published in
Current pharmaceutical biotechnology
Apoptosis could take place in the pathway dependent on death receptors or pathways dependent on mitochondria. In both, a key role is played by enzymes with protease activity, known as caspases. The aim of this study was to assess the variances in the expression pattern of caspase-dependent signaling pathways in the endometrial cancer cell line when...
Kiełbasiński, Kamil Peszek, Wojciech Grabarek, Beniamin O. Boroń, Dariusz Wierzbik-Strońska, Magdalena Oplawski, Marcin
Published in
Current Pharmaceutical Biotechnology
Background Salinomycin is part of a group of ionophore antibiotics characterized by an activity towards tumor cells. To this day, the mechanism through which salinomycin induces their apoptosis is not fully known yet. The goal of this study was to assess the expression pattern of genes and the proteins coded by them connected with the process of pr...
Kiełabsiński, Robert Kieszkowski, Przemysław Grabarek, Beniamin O. Boroń, Dariusz
Published in
Current Pharmaceutical Biotechnology
Background A reduced concentration of adiponectin is considered as an independent factor of the risk of inducing endometrial cancer. Cisplatin is a drug used in the therapy of this type of neoplasm. However, knowledge of the effects of cisplatin on the adiponectin level is still limited. Objective The purpose of this study was to assess the impact ...
Kieszkowski, Przemysław Dąbruś, Dariusz Grabarek, Beniamin O. Boroń, Dariusz
Published in
Current Pharmaceutical Biotechnology
Background Semaphorin 3F (SEMA3F) plays a substantial role in carcinogenesis, because of its role in inducing angiogenesis, and creating a microenvironment for the developing tumor. Objective The purpose of this work was to assess the impact of cisplatin, depending on the concentration and exposure time on the expression pattern of SEMA3F in an end...
Irais, Castillo-Maldonado de-la-Luz, Sevilla-González María Dealmy, Delgadillo-Guzmán Agustina, Ramírez-Moreno Nidia, Cabral-Hipólito Mario-Alberto, Rivera-Guillén Luis-Benjamín, Serrano-Gallardo María-del-Carmen, Vega-Menchaca David, Pedroza-Escobar
Published in
Current Pharmaceutical Biotechnology
Background Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions. Methods Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemic...
Moni, Sivakumar S. Alam, Mohammad F. Safhi, Mohammed M. Sultan, Muhammad H. Makeen, Hafiz A. Elmobark, Mohamed E.
Published in
Current Pharmaceutical Biotechnology
Background: Sorafenib is the first oral therapeutic agent to show the activity against human hepatocellular carcinoma. Sorafenib leads to severe toxicity due to the multiple-dose regimen. Reducing the overall dose of sorafenib through injectable dosage form to release sustainably is of therapeutically more important to combat drug-induced toxicity....
Bub, Gil Daniels, Matthew J
Published in
Current pharmaceutical biotechnology
In 1791, Galvani established that electricity activated excitable cells. In the two centuries that followed, electrode stimulation of neuronal, skeletal and cardiac muscle became the adjunctive method of choice in experimental, electrophysiological, and clinical arenas. This approach underpins breakthrough technologies like implantable cardiac pace...
Dziobek, Konrad Oplawski, Marcin Zmarzły, Nikola Gabarek, Beniamin O Kiełbasiński, Robert Kiełbasiński, Kamil Kieszkowski, Przemysław Talkowski, Karol Boroń, Dariusz
Published in
Current pharmaceutical biotechnology
Endometrial cancer is one of the most common gynecological cancer in the developed countries and occurs mainly in postmenopausal women. Angiogenesis is important for cancer formation as it provides nutrients for growing tumor mass. Most tumors do not show detectable Homeobox A5 (HOXA5 level), suggesting its potential role as a cancer suppressor. It...
Fedulova, Liliya V Basov, Alexandr A Vasilevskaya, Ekaterina R Dzhimak, Stepan S
Published in
Current pharmaceutical biotechnology
The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for the prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals. In the present work we took the rats with model of cyclophosphamide-induced im...
