In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes
Published in Current Opinion in Neurobiology
In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes
Editorial overview: Crosstalk between neural and immune systems
Published in Current Opinion in Neurobiology
Neuroinflammation and COVID-19.
Published in Current opinion in neurobiology
Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms, which range from mild, such as headaches, to severe, including hemorrhages. Current evidence suggests that there is no widespread infection of the central nervous system (CNS) by SARS-CoV-2, thu...
Neural architectures in the light of comparative connectomics
Published in Current Opinion in Neurobiology
• Technological innovations have lowered the barriers for whole-brain connectomics. • Comparative connectomics (CC) across suitable representative species is now feasible. • CC infers the common neural architecture across closely related animal species. • CC reveals the neural circuit details that make animals different from each other. • CC identi...
Neural circuit function redundancy in brain disorders.
Published in Current opinion in neurobiology
Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting da...
Neuronal replacement: Concepts, achievements, and call for caution
Published in Current Opinion in Neurobiology
• Restorative medicine aims to replace adequate, specific neuronal subtypes. • Criteria defining neuronal subtypes, given their high molecular diversity, are needed. • Single-cell RNA sequencing allows monitoring and refining transplanted neuron subtype identity. • Direct neuronal reprogramming from glia in vivo occurs with high efficiency. • Crite...
Regulatory roles of mitochondria and metabolism in neurogenesis.
Published in Current opinion in neurobiology
Neural stem cells (NSCs) undergo massive molecular and cellular changes during neuronal differentiation. These include mitochondria and metabolism remodelling, which were thought to be mostly permissive cues, but recent work indicates that they are causally linked to neurogenesis. Striking remodelling of mitochondria occurs right after mitosis of N...
Neurovascular crosstalk coordinates the central nervous system development
Published in Current Opinion in Neurobiology
Purpose of the review: The synchronic development of vascular and nervous systems is orchestrated by common molecules that regulate the communication between both systems. The identification of these common guiding cues and the developmental processes regulated by neurovascular communication are slowly emerging. In this review, we describe the mole...
Expressions of emotions across species
Published in Current Opinion in Neurobiology
What are emotions and how should we study them? These questions give rise to ongoing controversy amongst scientists in the fields of neuroscience, psychology and philosophy, and have resulted in different views on emotions [ 1 , 2 , 3 , 4 , 5 , 6 ]. In this review, we define emotions as functional states that bear essential roles in promoting survi...
The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isol...
Published in Current opinion in neurobiology
Social animal species present a vast repertoire of social interactions when encountering conspecifics. Reproduction-related behaviors, such as mating, parental care, and aggression, are some of the most rewarding types of social interactions and are also the most sexually dimorphic ones. This review focuses on rodent species and summarizes recent a...
