Ovciarikova, Jana Oliveira Souza, Rodolpho Ornitz Arrizabalaga, Gustavo Sheiner, Lilach
Published in
Current Opinion in Cell Biology
Integral membrane protein complexes control key cellular functions in eukaryotes by defining membrane-bound spaces within organelles and mediating inter-organelles contacts. Despite the critical role of membrane complexes in cell biology, most of our knowledge is from a handful of model systems, primarily yeast and mammals, while a full functional ...
Rivero-Ríos, Pilar Weisman, Lois S
Published in
Current opinion in cell biology
Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of cell function. These signaling molecules are difficult to study because they are extremely low abundance. Here, we focus on two of the lowest abundance phosphoinositides, PI(3,5)P2 and PI(5)P, which play critical roles in cellular homeostasis, membrane traffic...
Valls, Pablo Oriol Esposito, Alessandro
Published in
Current opinion in cell biology
Cell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, c...
Higashi, Torahiko L Uhlmann, Frank
Published in
Current opinion in cell biology
Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes - single molecule in vitro observations have yielded fascinating images of this process. When not extruding loops, SMC complexes are known to topologically entrap one or more DNAs. Here, we review how structural insight into the SMC complex cohesin has led ...
Ishii, Midori Akiyoshi, Bungo
Published in
Current Opinion in Cell Biology
Kinetochores are the macromolecular protein complexes that govern chromosome movement by binding spindle microtubules during mitosis and meiosis. Centromeres are the specific chromosomal regions that serve as the platform on which kinetochores assemble. Despite their essentiality for proper chromosome segregation, the size and organization of centr...
Jalal, Salma Dastidar, Sumitava Tedesco, Francesco Saverio
Published in
Current opinion in cell biology
Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model complex developmental dynamics and disease mechanisms not recapitulated in animal models or in conventional monolayer cell cultures. There has been impressive progress towards creating such models by using tissue engineering approaches to recapitulate a range ...
Yang, Qiutan Liberali, Prisca
Published in
Current opinion in cell biology
Collective behaviour emerges from interacting units within communities, such as migrating herds, swimming fish schools, and cells within tissues. At the microscopic level, collective behaviours include collective cell migration in development and cancer invasion, rhythmic gene expression in pattern formation, cell competition in homeostasis and can...
Klumperman, Judith Pucadyil, Thomas
Published in
Current opinion in cell biology
Dey, Gautam Baum, Buzz
Published in
Current opinion in cell biology
The defining feature of the eukaryotic cell, the nucleus, is bounded by a double envelope. This envelope and the nuclear pores within it play a critical role in separating the genome from the cytoplasm. It also presents cells with a challenge. How are cells to remodel the nuclear compartment boundary during mitosis without compromising nuclear func...
Papalazarou, Vassilis Machesky, Laura M
Published in
Current opinion in cell biology
The Arp2/3 complex orchestrates the formation of branched actin networks at the interface between the cytoplasm and membranes. Although it is widely appreciated that these networks are useful for scaffolding, creating pushing forces and delineating zones at the membrane interface, it has only recently come to light that branched actin networks are ...
