Saeed, Azhar Eshrat, Fariha Umar, Shahid Saeed, Anwaar
Published in
Current Colorectal Cancer Reports
Purpose of reviewGut microbiota has the ability to modify the metabolism of wide array of therapeutic drugs. Current treatment modalities used in colorectal cancer have a narrow therapeutic index with a side effects profile that decreases tolerance to these treatments and adversely affects treatment outcome. Harnessing the gut microbiota ability to...
Teke, Martha Endum Emuakhagbon, Valerie-Sue
Published in
Current Colorectal Cancer Reports
Purpose of ReviewThis review article strives to reflect on the historic surveillance debate in colorectal cancer, outline current strategies, and guidelines, and discuss new techniques being explored in surveilling colorectal adenocarcinoma.Recent FindingsWithin the past decade, major governing bodies have proposed surveillance guidelines with the ...
Bhatt, Divya B. Emuakhagbon, Valerie-Sue
Published in
Current Colorectal Cancer Reports
Purpose of ReviewThe following review is to assess the current methods, both non-invasive and invasive, in colorectal cancer screening and discuss novel screening techniques.Recent FindingsColorectal cancer continues to affect millions of people across the world. Through increased and widespread adoption of various screening methods, the rates of c...
DeStefanis, Rebecca A. Kratz, Jeremy D. Emmerich, Philip B. Deming, Dustin A.
Published in
Current Colorectal Cancer Reports
Purpose of ReviewTreatment options for patients with metastatic colorectal cancer continue to advance as the therapeutic implications of the molecular subtypes of this disease are becoming better understood. DNA sequencing and mismatch repair assessment are now standard of care analyses for patients with metastatic colorectal cancer This review des...
Chevallay, Mickael Meyer, Jeremy Wassmer, Charles-Henri Ris, Frederic Toso, Christian Buchs, Nicolas C.
Published in
Current Colorectal Cancer Reports
Purpose of ReviewThe access of the low rectum is a surgical challenge and, in case of cancer, the outcome of the patient depends on the quality of the surgery. The transanal total mesorectal excision (taTME) is a surgical technique with a combined abdominal and perineal approach. We review the literature for technical aspect of taTME as well as com...
Morris, Van K.
Published in
Current Colorectal Cancer Reports
Purpose of ReviewThis review seeks to detail the clinical and pathologic features specific to BRAFV600E colorectal cancer. Application of novel preclinical findings translated into the clinic for the development of new therapeutic options for patients with BRAFV600E metastatic colorectal cancer will be detailed.Recent FindingsWhile BRAF inhibitors ...
Follette, Craig Liebscher, Sean Mouw, Tyler Al-Kasspooles, Mazin
Published in
Current Colorectal Cancer Reports
Purpose of ReviewPeritoneal metastases (PM) secondary to colorectal cancer is associated with a poor prognosis. However, cytoreductive surgery with hyperthermia intraperitoneal chemotherapy (CRS/HIPEC) has risen to a more accepted roll in the treatment of peritoneal metastatic disease for various cancers; colorectal cancer is no exception. This rev...
Bridges, Kristina M. Greiner, K. Allen Umar, Shahid
Published in
Current Colorectal Cancer Reports
Purpose of ReviewStudies have identified differences between the gut microbiota of colorectal cancer (CRC) patients versus healthy individuals. In this review, we assess the scientific literature to determine if gut microbes should be considered causal, co-varying, or a necessary but not sufficient agent in CRC development.Recent FindingsOral bacte...
de Azevedo, José Moreira Vailati, Bruna Borba Julião, Guilherme Pagin São Fernandez, Laura Melina Perez, Rodrigo Oliva
Published in
Current Colorectal Cancer Reports
Purpose of ReviewThe surgical approach to rectal cancer has become significantly more complex with the introduction of neoadjuvant therapies and organ preservation strategies. Optimal radiological imaging in association with relevant clinical findings provides critical information for final surgical management decision. The present review focuses o...
Kim, Sooyeon Lee, Simon C. Skinner, Celette S. Brown, Cynthia J. Balentine, Courtney J.
Published in
Current Colorectal Cancer Reports
Purpose of ReviewReview strategies to improve outcomes of colorectal cancer treatment in older patients.Recent FindingsOlder colorectal patients face many barriers to recovery during their initial inpatient stay following surgery and after leaving the hospital. In addition to the risk of inpatient morbidity and mortality, older patients are more li...
