Jangam, Chaitanya Sadashiv Bhowmick, Shovonlal Chorge, Rekha Dhondiram Bharatrao, Lomate Dhanraj Patil, Pritee Chunarkar Chikhale, Rupesh V AlFaris, Nora Abdullah ALTamimi, Jozaa Zaidan Wabaidur, Saikh Mohammad Islam, Md Ataul
...
Published in
Computational biology and chemistry
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the present age, due to the rapid increase in antibiotic resistance worldwide, TB has become a major threat to human life. Regardless of significant efforts have been inclined to improve the healthcare systems for improving diagnosis, treatment, and anticipato...
Ram, Mousam Kumar Mukherjee, Koel Pandey, Dev Mani
Published in
Computational biology and chemistry
MicroRNAs (miRNAs) are one of the major cytoplasmic tools employed by the eukaryotes for post-transcriptional gene regulation. These ˜21 nt small non-coding RNA molecules are highly conserved among species which forms a base for identification of new miRNAs. In this study, we used previously known mature miRNAs to search their homologs in Arachis h...
K G, Arun C S, Sharanya J, Abhithaj C, Sadasivan
Published in
Computational biology and chemistry
Epigallocatechin gallate, a flavonoid from Camellia sinensis possess various pharmacological activities such as anticancer, antimicrobial and antioxidant etc. Adenosine deaminase, (ADA), is a key enzyme involved in the purine metabolism, the inhibitors of which is being considered as highly promising candidate for the development of anti-proliferat...
Lin, Xiaohui Li, Chao Ren, Weijie Luo, Xiao Qi, Yanpeng
Published in
Computational biology and chemistry
Defining important information from complex biological data is of great significance in biological study. It is known that the physiological and pathological changes in an organism are usually influenced by molecule interactions. Analyzing biological data by fusing the evaluation of the individual molecules and molecule interactions could induce a ...
Liu, Wenbin Du, Yugai Fang, Gang Kou, Zheng Wang, Xianghong Han, Henry
Published in
Computational biology and chemistry
Identifying stable gene markers at an individual level can help to understand the genetic mechanisms of each individual patient and accomplish personalized medicine. In this paper, we propose an efficient framework to identify sample-specific markers. Gene expression data first is transformed to a corresponding likelihood matrix to alleviate inhere...
Yesudasan, Sumith Averett, Rodney D
Published in
Computational biology and chemistry
The field of thrombosis and hemostasis is crucial for understanding and developing new therapies for pathologies such as deep vein thrombosis, diabetes related strokes, pulmonary embolisms, and hemorrhaging related diseases. In the last two decades, an exponential growth in studies related to fibrin clot formation using computational tools has been...
Zhang, Xiangyu Mao, Jianping Li, Wei Koike, Kazuo Wang, Jian
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Computational biology and chemistry
Three-dimension quantitative structure activity relationship (3D-QSAR) was one of the major statistical techniques to investigate the correlation of biological activity with structural properties of candidate molecules, and the accuracy of statistic greatly depended on molecular alignment methodology. Exhaustive conformational search and successful...
Suneja, Yadhu Gupta, Anil Kumar Chhuneja, Parveen Bains, Navtej Singh
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Computational biology and chemistry
Heat shock proteins are an important class of molecular chaperones known to impart tolerance under high temperature stress. sHSP26, a member of small heat shock protein subfamily is specifically involved in protecting plant's photosynthetic machinery. The present study aimed at identifying and characterizing sequence and structural variations in sH...
da Silva, Roger Sá Marins, Luis Fernando Almeida, Daniela Volcan Dos Santos Machado, Karina Werhli, Adriano V
Published in
Computational biology and chemistry
Fluorescent proteins have been applied in a wide variety of fields ranging from basic science to industrial applications. Apart from the naturally occurring fluorescent proteins, there is a growing interest in genetically modified variants that emit light in a specific wavelength. Genetically modifying a protein is not an easy task, especially beca...
Boonma, Thitiya Nutho, Bodee Rungrotmongkol, Thanyada Nunthaboot, Nadtanet
Published in
Computational biology and chemistry
Hepatitis C virus (HCV) NS3/4A protease is an attractive target for the development of antiviral therapy. However, the evolution of antiviral drug resistance is a major problem for treatment of HCV infected patients. Understanding of drug-resistance mechanisms at molecular level is therefore very important for the guidance of further design of anti...
