Roggero, Pier Francesco Calistri, Arianna Palù, Giorgio
Published in
Computational and Structural Biotechnology Journal
Our hypothesis about evolution of the COVID-19 pandemic foresees an inverse relation between infectivity (R0) and lethality (L) of SARS-CoV-2. The above parameters are driven by a continuing mutation process granting the virus a clear survival advantage over virulence. For interpreting this relation we adopted a simple equation, R0 × L ≈ k, by whic...
Felipe Cuspoca, Andrés Isaac Estrada, Pablo Velez-van-Meerbeke, Alberto
Published in
Computational and structural biotechnology journal
The development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in record time to cope with the ongoing coronavirus disease 2019 (COVID-19) pandemic has led to uncertainty about their use and the appearance of adverse neurological reactions. The SARS-CoV-2 spike protein (SP) is used to produce neutralizing antibodie...
Chen, Li Saykin, Andrew J. Yao, Bing Zhao, Fengdi
Published in
Computational and Structural Biotechnology Journal
Traditional approaches for diagnosing Alzheimer’s disease (AD) such as brain imaging and cerebrospinal fluid are invasive and expensive. It is desirable to develop a useful diagnostic tool by exploiting biomarkers obtained from peripheral tissues due to their noninvasive and easily accessible characteristics. However, the capacity of using DNA meth...
Zhao, Xichen Zhang, Yuxin Hang, Daiyun Meng, Jia Wei, Zhen
Published in
Computational and Structural Biotechnology Journal
Post-transcriptional RNA modifications are involved in a range of important cellular processes, including the regulation of gene expression and fine-tuning of the functions of RNA molecules. To decipher the context-specific functions of these post-transcriptional modifications, it is crucial to accurately determine their transcriptomic locations an...
Shen, Xilin Wu, Bingbing Jiang, Wei Li, Yu Zhang, Yuping Zhao, Kun Nie, Nanfang Gong, Lin Liu, Yixiao Zou, Xiaohui
...
Published in
Computational and Structural Biotechnology Journal
Although aging is an increasingly severe healthy, economic, and social global problem, it is far from well-modeling aging due to the aging process’s complexity. To promote the aging modeling, here we did the quantitative measurement based on aging blood transcriptome. Specifically, the aging blood transcriptome landscape was constructed through ens...
González-Llera, Laura Sobrido-Cameán, Daniel Santos-Durán, Gabriel N. Barreiro-Iglesias, Antón
Published in
Computational and Structural Biotechnology Journal
Sea lampreys are a vertebrate model of interest for the study of spontaneous axon regeneration after spinal cord injury (SCI). Axon regeneration research in lampreys has focused on the study of giant descending neurons, but less so on neurochemically-distinct descending neuronal populations with small caliber axons. Corticotropin-releasing hormone ...
Lu, Lu Qin, Jiale Chen, Jiandong Yu, Na Miyano, Satoru Deng, Zhenzhong Li, Chen
Published in
Computational and Structural Biotechnology Journal
Since COVID-19 emerged in 2019, significant levels of suffering and disruption have been caused on a global scale. Although vaccines have become widely used, the virus has shown its potential for evading immunities or acquiring other novel characteristics. Whether current drug treatments are still effective for people infected with Omicron remains ...
Antunes, Miguel Sá-Correia, Isabel
Published in
Computational and Structural Biotechnology Journal
Protein phosphorylation is the most common and versatile post-translational modification occurring in eukaryotes. In yeast, protein phosphorylation is fundamental for maintaining cell growth and adapting to sudden changes in environmental conditions by regulating cellular processes and activating signal transduction pathways. Protein kinases cataly...
Gallego-Villarejo, Lucía Wallin, Cecilia Król, Sylwia Enrich-Bengoa, Jennifer Suades, Albert Aguilella-Arzo, Marcel Gomara, María José Haro, Isabel Wärmlander, Sebastian Muñoz, Francisco J
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Published in
Computational and structural biotechnology journal
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid ne...
Moya-Rodríguez, Andrés Xie, Bingqing Cook, Dylan Klineberg, Maren Nathan, Sandeep Hammes, Mary Basu, Anindita
Published in
Computational and Structural Biotechnology Journal
End-Stage Renal Disease (ESRD) patients require arteriovenous fistulas (AVF) that allow a mature vein to withstand hemodialysis. Unfortunately, venous thrombosis and stenosis in the cephalic vein arch after AVF placement is common and heavily influenced by hemodynamics. To better assess forces and flow behavior in the cephalic arch, we have built p...
