Chowdhury, Ratul Boorla, Veda Sheersh Maranas, Costas D.
Published in
Computational and Structural Biotechnology Journal
SARS-CoV-2 is a novel highly virulent pathogen which gains entry to human cells by binding with the cell surface receptor – angiotensin converting enzyme (ACE2). We computationally contrasted the binding interactions between human ACE2 and coronavirus spike protein receptor binding domain (RBD) of the 2002 epidemic-causing SARS-CoV-1, SARS-CoV-2, a...
Calvelo, Martín Piñeiro, Ángel Garcia-Fandino, Rebeca
Published in
Computational and Structural Biotechnology Journal
The era of the explosion of immersive technologies has bumped head-on with the coronavirus disease 2019 (COVID-19) global pandemic caused by the severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2). The proper understanding of the three-dimensional structures that compose the virus, as well as of those involved in the infection process and ...
Zhang, Zhilan Li, Lin Li, Mengyuan Wang, Xiaosheng
Published in
Computational and Structural Biotechnology Journal
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 29 million people and has caused more than 900,000 deaths worldwide as of September 14, 2020. The SARS-CoV-2 human cell receptor ACE2 has recently received extensive attention for its role in SARS-CoV-2 infection . Many studies have also explored the association...
Sater, Vincent Viailly, Pierre-Julien Lecroq, Thierry Ruminy, Philippe Bérard, Caroline Prieur-Gaston, Élise Jardin, Fabrice
Published in
Computational and Structural Biotechnology Journal
Motivation With Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at very high depths thus allowing to detect abnormali...
Li, Qizhang Wang, Zhiying Zheng, Qiang Liu, Sen
Published in
Computational and Structural Biotechnology Journal
In less than eight months, the COVID-19 (coronavirus disease 2019) caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus has resulted in over 20,000,000 confirmed cases and over 700,000 deaths around the world. With the increasing worldwide spreading of this disease, the lack of effective drugs against SARS-CoV-2 infectio...
Hussein, Maytham Hu, Xiaohan Paulin, Olivia K.A. Crawford, Simon Tony Zhou, Qi Baker, Mark Schneider-Futschik, Elena K. Zhu, Yan Li, Jian Velkov, Tony
...
Published in
Computational and Structural Biotechnology Journal
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable. Combining antibiotics with various FDA-approved non-antibiotic drugs has emerged as a novel strategy against otherwise untreatable multi-drug re...
Shinkai, Soya Onami, Shuichi Nakato, Ryuichiro
Published in
Computational and Structural Biotechnology Journal
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology. Recent studies using live-imaging and polymer simulation have suggested that the higher-order chromatin structures are dynamic; the stochastic fluctuations of nucleosomes and genomic loci cannot...
Postic, Guillaume Janel, Nathalie Tufféry, Pierre Moroy, Gautier
Published in
Computational and Structural Biotechnology Journal
For three decades now, knowledge-based scoring functions that operate through the “potential of mean force” (PMF) approach have continuously proven useful for studying protein structures. Although these statistical potentials are not to be confused with their physics-based counterparts of the same name— i.e. PMFs obtained by molecular dynamics simu...
Iyer, Vaishnavi Srinivasan Jiang, Long Shen, Yunbing Boddul, Sanjaykumar V. Panda, Sudeepta Kumar Kasza, Zsolt Schmierer, Bernhard Wermeling, Fredrik
Published in
Computational and Structural Biotechnology Journal
Over the last decade Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has been developed into a potent molecular biology tool used to rapidly modify genes or their expression in a multitude of ways. In parallel, CRISPR-based screening approaches have been developed as powerful discovery platforms for dissecting the genetic basis o...
Giordano, Daniela Pesce, Alessandra Vermeylen, Stijn Abbruzzetti, Stefania Nardini, Marco Marchesani, Francesco Berghmans, Herald Seira, Constantí Bruno, Stefano Javier Luque, F.
...
Published in
Computational and Structural Biotechnology Journal
While the functions of the recently discovered cytoglobin, ubiquitously expressed in vertebrate tissues, remain uncertain, Antarctic fish provide unparalleled models to study novel protein traits that may arise from cold adaptation. We report here the spectral, ligand-binding and enzymatic properties (peroxynitrite isomerization, nitrite-reductase ...
