Published in Communications Biology
Evanthia Pangou and co-authors review recent insights into the important roles of non-proteolytic ubiquitylation in cellular signaling as well as in physiology and disease.
Published in Communications Biology
Visualisation of rat trigeminal ganglia activation during ophthalmic or maxillary nociceptive stimulations shows atypical tortuous vascularisation and a somatotopic hemodynamic response.
Published in Communications Biology
A new middle Permian fossil locality featuring a large abundance of exceptionally preserved plants and insects is identified in the Karoo Basin of South Africa.
Published in Communications Biology
To improve our understanding of the pathological role of TET2 mutations, Pronier, Imanci et al. use mice and human cells to show that TET2 downregulation promotes the production of macrophage migration inhibitory factor (MIF). In addition they show that whilst TET2 is recruited to the MIF promoter in healthy monocytes, decreased TET2 expression res...
Published in Communications Biology
This population genomics study identifies the complex multiple introduction history of Spodoptera frugiperda (fall armyworm) from the Americas, into Africa and Asia. This provides new insight into the ‘east-to-west’ directionality of gene flow, and suggests ample genomic exchange at the nuclear level.
Published in Communications biology
The origins of human language remains a major question in evolutionary science. Unique to human language is the capacity to flexibly recombine a limited sound set into words and hierarchical sequences, generating endlessly new sentences. In contrast, sequence production of other animals appears limited, stunting meaning generation potential. Howeve...
Published in Communications biology
G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors. Despite considerable insights into their pharmacology, the GPCR architecture at the cell surface still remains largely unexplored. Herein, we present the specific unfolding of different GPCRs at the surface of living mammalian cells by atomic force microscopy-bas...
Published in Communications Biology
The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.
Published in Communications Biology
In this Comment, Ciampitti et al. introduces a more relevant conceptual framework bridging soil and plant processes to untangle true gains of N for field crops rather than indirect progress merely based on yield.
Published in Communications biology
Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced ...
