Bai, Yu-Ting Wang, Xin He, Ming-Jing Xie, Ji-Rong Chen, Xiao-Jie Zhou, Gang
Published in
Combinatorial chemistry & high throughput screening
The role of lipid droplets (LDs) and lipid droplet-associated genes (LD-AGs) remains unclear in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate LDs in HNSCC and identify LD-AGs essential for the diagnosis and prognosis of HNSCC patients. The LDs in the HNSCC and normal cell lines were stained with oil red O. Bioinform...
Zhao, Quangang Chen, Guohua Yang, Xin Wang, Taiyong Yuan, Shuhong Meng, Qi
Published in
Combinatorial chemistry & high throughput screening
Uterine Corpus Endometrial Carcinoma (UCEC) is a common malignancy of the female genital tract. The sine oculis homeobox homolog 1 (SIX1) protein has been documented to be important for tumor progression. However, little is known about the relationship between SIX1 and the pathogenesis of UCEC. This study aimed to assess the prognostic value of bio...
Feng, Shicheng Zhang, Xiuxiu Gu, Xuyu Zhou, Min Chen, Yan Wang, Cailian
Published in
Combinatorial chemistry & high throughput screening
As a subgroup of lung cancer, small cell lung cancer (SCLC) is characterized by a short tumor doubling time, high rates of early occurred distant cancer spread and poor outcomes. Our study aimed to identify novel molecular markers associated with SCLC prognosis. Microarray data from the Gene Expression Omnibus (GEO) database of SCLC tumors and pair...
Wu, Fangping Wu, Guolin Li, Tianyi Lu, Wenwen Fu, Tianxiao Zhang, Zhenyi
Published in
Combinatorial chemistry & high throughput screening
Radix Paeoniae Alba is a traditional Chinese herbal medicine. It can accelerate salivary secretion and alleviate the dry mouth of patients with Sjogren's syndrome (SS). Although it is widely used in clinical treatment, its target and mechanism remain unclear. This study aims to analyze the main components of Radix Paeoniae Alba, explore the target ...
Rivero-Cruz, Isabel Gutiérrez-González, José Alberto Pérez-Vásquez, Araceli Villaseñor, José Luis Mata, Rachel
Published in
Combinatorial chemistry & high throughput screening
Ageratina is an American genus of the tribe Eupatorieae (Asteraceae), comprising about 320 species. In Mexico, some species of this genus are highly valued for their medicinal properties, particularly A. pichinchensis, A. petiolaris, and A. grandifolia. Furthermore, herbal preparations of A. pichinchensis are available for treating several mycoses....
Luo, Benshen Wang, Chen Wang, Zhengyu Chen, Chuanguo Peng, Xiaozhuang Xu, Qingchun
Published in
Combinatorial chemistry & high throughput screening
Acute pancreatitis can eventually lead to morbidity and mortality. The present study aimed to identify the differentially expressed microRNAs (miRNAs) that are related to acute pancreatitis and explore the in vitro functional role of miR-92b in acute pancreatitis. Bioinformatics analysis was used to identify differentially expressed miRNAs in caeru...
Peng, Jing Wu, Yiwen Deng, Sijun Cao, Pu Yang, Wei Gong, Tingyi Lei, Xiaoyong Yang, Xiaoyan
Published in
Combinatorial chemistry & high throughput screening
Gastric cancer is one of the most common and highest mortality rate cancers in the world. Exosomes are vesicles secreted by cells carrying different types of molecules, such as protein and RNA. Numerous studies have confirmed that exosomes are involved in various stages of the occurrence and development of gastric cancer and play an important role....
Wu, Guang Guan, Yang Chen, Jie Zhu, Mei-Ning Qiu, Yong-Wei Zhu, Cai-Qing Wu, Yong-Zhong Zhong, Guo-Yue Ma, Qin-Ge Wei, Rong-Rui
...
Published in
Combinatorial chemistry & high throughput screening
Pyrethrum tatsienense (Bureau & Franch.) Ling ex C. Shih (PTLCS) belongs to the family Compositae, which is a perennial medicinal plant mainly distributed in the Qinghai-Tibet Plateau of China. This review provides a comprehensive summary of the ethnopharmacology, phytochemistry, and pharmacology of PTLCS. This review offers valuable references and...
Fan, Yanbo Wang, Wei He, Zhiwei Li, Jingjing Ding, Nian Lu, Lijun Zhang, Jun Xie, Miaomiao
Published in
Combinatorial chemistry & high throughput screening
Asthma is a severe chronic inflammatory airway disease. Kechuanning plaster has excellent efficacy in the treatment of asthma. The aim of this study was to analyze the molecular mechanisms of Kechuanning plaster in the treatment of asthma. An asthma model was constructed using Sprague Dawley rats. Differentially expressed genes (DEGs) were screened...
Bhaskar, Vaishnav Kumar, Sunil Nair, Aathira S Rajappan, Krishnendu P Sudevan, Sachithra T Parambi, Della G T Al-Sehemi, Abdullah G Zachariah, Subin M Pappachen, Leena K
Published in
Combinatorial chemistry & high throughput screening
Tuberculosis is one of the oldest known infectious diseases to mankind, caused by Mycobacterium tuberculosis. Although current treatment using first-line anti-tubercular drugs is proven to be effective, an infection caused by resistant strains, as in multidrug-resistant and extensive drug- resistant tuberculosis is still an impending challenge to t...
