Kong, Xiangpan He, Dawei Wang, Quan
Published in
Combinatorial chemistry & high throughput screening
This study aimed to investigate the differential expression of mitophagyrelated genes in osteosarcoma patients with distinct prognostic outcomes and explore potential molecular regulatory mechanisms. We analyzed microarray data from metastatic and nonmetastatic osteosarcoma patients using the UCSC dataset. Differential gene screening and intersecti...
Zhao, Zhiming Xu, Xu Ma, Shijing Li, Li
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Combinatorial chemistry & high throughput screening
Background Malignant gliomas are the most common type of primary malignant brain tumors. Pantothenate kinase 1 (PANK1) mRNA is highly expressed in several metabolic processes, implying that PANK1 plays a potential role in metabolic programming in cancers. However, the role of PANK1 in glioma has not been fully explored. Methods Public datasets (The...
Fang, Xi Jiang, Xiao-Feng Zhang, Yi-Piao Zhou, Cheng-Liang Dong, Ying-Jie Bo-Li, Lv, Gui-Yuan Chen, Su-Hong
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Combinatorial chemistry & high throughput screening
This study investigated the molecular action mechanism of a compound herb, also known as the Dendrobium officinale throat-clearing formula (QYF), by using network pharmacology and animal experimental validation methods to treat chronic pharyngitis (CP). The active ingredients and disease targets of QYF were determined by searching the Batman-TCM an...
Wang, Kangwei Chu, Yan Zhang, Hongqiang Qu, Xinglong Wang, Bing Han, Yu
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Combinatorial chemistry & high throughput screening
The improvements in the treatment of colorectal cancer (CRC) and prolongation of survival time have improved the incidence of bone metastasis. Forkhead box D3 (FOXD3) is involved in the development of CRC. However, the role and mechanism of FOXD3 in CRC bone metastases development are unknown. Using the combined bioinformatics and cytology experime...
Zhang, Jingmei Xue, Siming Chen, Huan Jiang, Haixu Gao, Pengrong Lu, Linghui Wang, Qiyan
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Combinatorial chemistry & high throughput screening
To investigate the active ingredients and the mechanisms of Si-miaoyong- an Decoction (SMYA) in the treatment of coronary heart disease (CHD) by using network pharmacology, molecular docking technology, and in vitro validation. Through the Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), Uniprot database, GeneCards datab...
Wang, Guozhen Liu, Zijia Zheng, Yuchen Sheng, Chao Hou, Xiaonan Yao, Mengfei Zong, Qi Tang, Duo Zhou, Zhixiang Zhang, Tie
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Combinatorial chemistry & high throughput screening
Gout is a common inflammatory arthritis, which is mainly caused by the deposition of monosodium urate (MSU) in tissues. Transcriptomics was used to explore the pathogenesis and treatment of gout in our work. The objective of the study was to analyze and validate potential therapeutic targets and biomarkers in THP-1 cells that were exposed to MSU. T...
Hu, Jian-Yu Gao, Ya-Ru Bao, Yu-Qi Zhao, Jing Liu, Bo Zhao, Chang-Wei Zhang, Zheng-Yao
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Combinatorial chemistry & high throughput screening
As a malignant tumor, osteosarcoma (OS) ranks first place among adolescent cancers and is susceptible to developing resistance to chemotherapeutic agents. Differently, Traditional Chinese medicine (TCM) has multiple pharmacodynamic targets and complex biological components, which can inhibit tumor survival and drug resistance and gradually play an ...
Ahmed, Fee Faysal Podder, Anamika Bulbul, Md Farhad Hossain, Md Amzad Hasan, Mahedi Sarkar, Md Abdur Rauf Kim, Daijin
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Combinatorial chemistry & high throughput screening
To elucidate the detailed mechanisms of citrullination at the molecular level and design drugs applicable to major human diseases, predicting protein citrullination sites (PCSs) is essential. Using experimental approaches to predict PCSs is time-consuming and costly. However, there is a limited scope of the current PCS predictors. In particular, mo...
Chen, Jiamin Jin, Dan Shao, Liming Wang, Lingling Zhou, Liuzhi Cai, Jianting
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Combinatorial chemistry & high throughput screening
Colorectal cancer (CRC) has become the most prevalent gastrointestinal malignant tumor, ranking third (10.2%) in incidence and second (9.2%) in death among all malignancies globally. The most common histological subtype of CRC is colon adenocarcinoma (COAD), although the cause of CRC remains unknown, as there are no valid biomarkers. A thorough inv...
Montoya-Inzunza, Luis Aurelio Heredia, J Basilio Patra, Jayanta Kumar Gouda, Sushanto Kerry, Rout George Das, Gitishree Gutierrez-Grijalva, Erick Paul
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Combinatorial chemistry & high throughput screening
Plants from the genus Phoradendron and Viscum, also known as American and European mistletoe, are a group of hemiparasitic plants traditionally used to treat many diseases. Mistletoes have a rich content of natural compounds like terpenes, alkaloids, proteins, and phenolic compounds associated with their potential medicinal properties. In this sens...
