Corrigendum: Niche Cells and Signals that Regulate Lung Alveolar Stem Cells In Vivo.
Published in Cold Spring Harbor perspectives in biology
Erratum: Mechanisms and Impact of Symbiotic Phosphate Acquisition
Published in Cold Spring Harbor Perspectives in Biology
Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast.
Published in Cold Spring Harbor perspectives in biology
Noncoding introns are removed from nuclear precursor messenger RNA (pre-mRNA) in a two-step phosphoryl transfer reaction by the spliceosome, a dynamic multimegadalton enzyme. Cryo-electron microscopy (cryo-EM) structures of the Saccharomyces cerevisiae spliceosome were recently determined in eight key states. Combined with the wealth of available g...
Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum Homeostasis.
Published in Cold Spring Harbor perspectives in biology
The endoplasmic reticulum (ER) is a dynamic organelle responsible for many cellular functions in eukaryotic cells. Proper redox conditions in the ER are necessary for the functions of many luminal pathways and the maintenance of homeostasis. The redox environment in the ER is oxidative compared with that of the cytosol, and a network of oxidoreduct...
Stress Granules and Processing Bodies in Translational Control.
Published in Cold Spring Harbor perspectives in biology
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA granules that dynamically sequester translationally inactive messenger ribonucleoprotein particles (mRNPs) into compartments that are distinct from the surrounding cytoplasm. mRNP remodeling, silencing, and/or storage involves the dynamic partitioning of closed-loop pol...
Stomatal Development and Perspectives toward Agricultural Improvement.
Published in Cold Spring Harbor perspectives in biology
Stomata are small pores on the surface of land plants that facilitate gas exchange-acquiring CO2 from surrounding atmosphere and releasing water vapor. In adverse conditions, such as drought, stomata close to minimize water loss. The activities of stomata are vital for plant growth and survival. In the last two decades, key players for stomatal dev...
Ribosome Profiling: Global Views of Translation.
Published in Cold Spring Harbor perspectives in biology
The translation of messenger RNA (mRNA) into protein and the folding of the resulting protein into an active form are prerequisites for virtually every cellular process and represent the single largest investment of energy by cells. Ribosome profiling-based approaches have revolutionized our ability to monitor every step of protein synthesis in viv...
Role of Polyphosphate in Amyloidogenic Processes.
Published in Cold Spring Harbor perspectives in biology
Polyphosphate (polyP), an extremely simple polyanion, has long been known to be involved in a variety of different cellular processes, ranging from stress resistance, biofilm formation, and virulence in bacteria to bone mineralization, blood clotting, and mammalian target of rapamycin (mTOR) signaling in mammalian organisms. Our laboratory recently...
Illuminating Genomic Dark Matter with RNA Imaging.
Published in Cold Spring Harbor perspectives in biology
In the postgenomic era, it is clear that the human genome encodes thousands of long noncoding RNAs (lncRNAs). Along the way, RNA imaging (e.g., RNA fluorescence in situ hybridization [RNA-FISH]) has been instrumental in identifying powerful roles for lncRNAs based on their subcellular localization patterns. Here, we explore how RNA imaging technolo...
Calcium Sensors in Neuronal Function and Dysfunction.
Published in Cold Spring Harbor perspectives in biology
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular function. Neuronal Ca2+ signaling processes have also become adapted to modulate the function of specific pathways over a wide variety of time domains and these can have effects on, for example, axon outgrowth, neuronal survival, and changes in synaptic stren...
