Ogdie, Alexis Walsh, Jessica A Chakravarty, Soumya D Peterson, Steven Lo, Kim Hung Kim, Lilianne Li, Nan Hsia, Elizabeth C Chan, Eric K H Kavanaugh, Arthur
...
Published in
Clinical rheumatology
To evaluate changes in health-related quality of life (HRQoL) and productivity following treatment with intravenous (IV) golimumab in patients with psoriatic arthritis (PsA). Patients were randomized to IV golimumab 2 mg/kg (n=241) at Weeks 0, 4, then every 8 weeks (q8w) through Week 52 or placebo (n=239) at Weeks 0, 4, then q8w, with crossover to ...
Lau, Chak Sing Chen, Yi-Hsing Lim, Keith de Longueville, Marc Arendt, Catherine Winthrop, Kevin
Published in
Clinical rheumatology
To evaluate the incidence rate (IR) of tuberculosis (TB) and viral hepatitis B and C (HBV/HCV) during certolizumab pegol (CZP) treatment, worldwide and in Asia-Pacific countries, across clinical trials and post-marketing reports (non-interventional studies and real-world practice). CZP safety data were pooled across 49 clinical trials from 1998 to ...
Li, Liubing Liu, Chenxi Cheng, Linlin Yan, Songxin Chen, Haizhen Li, Yongzhe
Published in
Clinical rheumatology
The objectives of this study are to analyze the association between anti-nuclear matrix protein 2 (NXP2) autoantibody and idiopathic inflammatory myopathies (IIMs) and to assess the diagnostic and prognostic relevance of anti-NXP2 autoantibody in patients with IIMs. A systematic search was performed in PubMed, Web of Science, EMBASE, the Cochrane L...
Colaci, Michele Dal Bosco, Ylenia Schinocca, Claudia Ronsivalle, Giuseppe Guggino, Giuliana De Andres, Ilenia Russo, Alessandra A Sambataro, Domenico Sambataro, Gianluca Malatino, Lorenzo
...
Published in
Clinical rheumatology
Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction and fibroblasts activation. Microvascular disease may be easily observed by means of nailfold capillaroscopy. Recent evidences emphasized also the involvement of large-medium arteries in SSc, mainly in terms of increased stiffness of the vessel wall. The stud...
Xu, Qin Jin, Xuexiao Jiang, Yu Dang, Xin Han, Yongmei
Published in
Clinical rheumatology
The JAK family (JAK1, JAK2, JAK3, and TYK2) have recently emerged as a potential therapeutic management in controlling severe and refractory dermatomyositis. Meanwhile, the progress in the discovery of JAK blockers is significant, with an increasing number of selective JAK inhibitors reported and some are in or prepare for clinical trials. However,...
Takada, Toshinori Asakawa, Katsuaki Barrios, Roberto
Published in
Clinical rheumatology
Patients with clinically amyopathic dermatomyositis (CADM) have a risk of developing rapidly progressive interstitial lung disease (ILD). CADM-ILD is associated with the anti-MDA-5 antibody. In the USA, however, patients with CADM have these antibodies less frequently than those in Japan. In addition, those with this disorder are less often complic...
Goswami, Rudra Prosad Sit, Hiramanik Chatterjee, Moumita Lahiri, Debasish Sircar, Geetabali Ghosh, Parasar
Published in
Clinical rheumatology
(1) Development and validation of a composite ultrasound score (cUSS) for the diagnosis of carpal tunnel syndrome (CTS). (2) To predict treatment response after local corticosteroid injection. Wrists of CTS patients and controls were evaluated with high-resolution ultrasound and cross-sectional area of median nerve at carpal tunnel inlet (CSAp) and...
Zhang, Jian-Luo Zhang, Cun-Li Zhou, Bai-Gang Lei, Bo-Yi Zhang, Bo Yang, Hong-Tao
Published in
Clinical rheumatology
Osteoarthritis (OA) ranks the most common joint disorder and the leading cause of disability. Growing evidence has revealed that OA has a strong genetic background, except for aging and obesity. The aim of this study is to determine the associations between potential functional variants of the GLIS3 and GLIS3-AS1 gene and risk of knee OA among a Ch...
Wangkaew, Suparaporn Pota, Panupong Prasertwittayakij, Narawudt Phrommintikul, Arintaya
Published in
Clinical rheumatology
We investigated the incidence, predictors, and survival of pulmonary hypertension (PH) determined by Doppler echocardiography in Thai patients with early SSc (systemic sclerosis), in which the majority were diffuse cutaneous SSc (DcSSc) with anti-topoisomerase I-positive. We used an inception cohort study of patients with early SSc seen at the Rheu...
Palmer, Shea Davey, Indi Oliver, Laura Preece, Amara Sowerby, Laura House, Sophie
Published in
Clinical rheumatology
'Syndromic hypermobility' encompasses heritable connective tissue disorders such as hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders which are characterised by excessive joint range of motion and pain. Conservative interventions such as exercise are the cornerstone of management, yet their effectiveness is unclear. To systema...
