Jamee, Mahnaz Moniri, Shakiba Zaki-Dizaji, Majid Olbrich, Peter Yazdani, Reza Jadidi-Niaragh, Farhad Aghamahdi, Fatemeh Abolhassani, Hassan Condliffe, Alison M Aghamohammadi, Asghar
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Published in
Clinical reviews in allergy & immunology
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a novel primary immunodeficiency (PID) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3CD) or regulatory p85α (PIK3R1) subunits leading to APDS1 and APDS2, respectively. Patients with APDS present a spectrum of clinical manifestations, particularly recurren...
You, Hanxiao Xu, Dong Zhao, Jiuliang Li, Jing Wang, Qian Tian, Xinping Li, Mengtao Zeng, Xiaofeng
Published in
Clinical reviews in allergy & immunology
The dysregulation of the JAK-STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review, we elucidate the invol...
Xu, Ting Zhang, Guangfeng Lin, Haobo Xie, Yuesheng Feng, Yuan Zhang, Xiao Dong, Guangfu
Published in
Clinical reviews in allergy & immunology
Diffuse alveolar hemorrhage (DAH) is a rare but potentially deadly manifestation of systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical characteristics and risk factors of DAH in SLE. A systematic review and meta-analysis of previous observational studies compared the clinical characteristics and risk factors b...
D'Aguanno, Vittorio Ralli, Massimo Artico, Marco Russo, Francesca Yoshie Scarpa, Alfonso Fiore, Marco Tirassa, Paola Severini, Cinzia de Vincentiis, Marco Greco, Antonio
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Published in
Clinical reviews in allergy & immunology
Amyloidosis constitutes a large spectrum of diseases characterized by an extracellular deposition of a fibrillar aggregate, generating insoluble and toxic amasses that may be deposited in tissues in bundles with an abnormal cross-β-sheet conformation, known as amyloid. Amyloid may lead to a cell damage and an impairment of organ function. Several d...
Huang, Chao Li, Fengqi Wang, Jian Tian, Zhigang
Published in
Clinical reviews in allergy & immunology
Asthma is a chronic pulmonary disease, highly associated with immune disorders. The typical symptoms of asthma include airway hyperresponsiveness (AHR), airway remodeling, mucus overproduction, and airflow limitation. The etiology of asthma is multifactorial and affected by genetic and environmental factors. Increasing trends toward dysbiosis, smok...
Palma Dos Reis, Catarina R Cardoso, Gonçalo Carvalho, Carolina Nogueira, Isabel Borges, Augusta Serrano, Fátima
Published in
Clinical reviews in allergy & immunology
Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease associated with major obstetrical complications such as gestational loss, preterm delivery, fetal growth restriction (FGR) and preeclampsia. Published literature is not consensual regarding the main risk factors for each of these outcomes. Our goal with this study was to determine ...
Chen, Ru-Xuan Zhao, Li-Dan Xiao, Xin-Yue Song, Lan Du, Hua-Yang Xu, Zuo-Jun Feng, Rui-E Yang, Hua-Xia Fei, Yun-Yun Zhang, Wen
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Published in
Clinical reviews in allergy & immunology
The aim of this study is to investigate the clinical features and outcome of interstitial lung disease (ILD)-onset rheumatoid arthritis (RA) and anti-citrullinated protein antibody (ACPA)-positive ILD-only patients. Arthritis-onset and ILD-onset RA-ILD and ACPA-positive ILD-only patients consecutively admitted to Peking Union Medical College Hospit...
Sharma, Ambika Kaur, Sargeet Sarkar, Malay Sarin, B C Changotra, Harish
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Clinical reviews in allergy & immunology
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that leads to difficulties in breathing. Chronic inflammation is another important characteristic of COPD which leads to immune cell infiltration and helps in the alveolar destruct...
Hamilton, Daniel Lehman, Heather
Published in
Clinical reviews in allergy & immunology
Asthma has been increasingly recognized as being a heterogeneous disease with multiple distinct mechanisms and pathophysiologies. Evidence continues to build regarding the existence of different cell types, environmental exposures, pathogens, and other factors that produce a similar set of symptoms known collectively as asthma. This has led to a mo...
Choudhury, Shelly Baker, Susan
Published in
Clinical reviews in allergy & immunology
Eosinophilic esophagitis (EoE) is a chronic, relapsing inflammatory disease of the esophagus, characterized by the presence of significant esophageal mucosal eosinophilic infiltrates. The clinical presentation of EoE in childhood may include failure to thrive and feeding intolerance. The complication of food impaction is often related to the presen...
