Cheng, Zhangkai Jason Zhan, Zhiqing Xue, Mingshan Zheng, Peiyan Lyu, Jiali Ma, Jing Zhang, Xiaohua Douglas Luo, Wenting Huang, Huimin Zhang, Yong
...
Published in
Clinical reviews in allergy & immunology
In December 2019, the COVID-19 pandemic quickly spread throughout China and beyond, posing enormous global challenges. With prompt, vigorous, and coordinated control measures, mainland China contained the spread of the epidemic within two months and halted the epidemic in three months. Aggressive containment strategy, hierarchical management, ratio...
Qin, Rundong He, Li Yang, Zhaowei Jia, Nan Chen, Ruchong Xie, Jiaxing Fu, Wanyi Chen, Hao Lin, Xinliu Huang, Renbin
...
Published in
Clinical reviews in allergy & immunology
Abnormal immunological indicators associated with disease severity and mortality in patients with COVID-19 have been reported in several observational studies. However, there are marked heterogeneities in patient characteristics and research methodologies in these studies. We aimed to provide an updated synthesis of the association between immune-r...
Zhang, Jin-Jin Dong, Xiang Liu, Guang-Hui Gao, Ya-Dong
Published in
Clinical reviews in allergy & immunology
The outbreak of the coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an evolving global health crisis. Currently, a number of risk factors have been identified to have a potential impact on increasing the morbidity of COVID-19 in adults, including old age, male sex, pr...
Cheng, Zhangkai J Li, Bizhou Zhan, Zhiqing Zhao, Zifan Xue, Mingshan Zheng, Peiyan Lyu, Jiali Hu, Chundi He, Jianxing Chen, Ruchong
...
Published in
Clinical reviews in allergy & immunology
The current COVID-19 global pandemic poses immense challenges to global health, largely due to the difficulty to detect infection in the early stages of the disease, as well as the current lack of effective antiviral therapy. Research and understanding of the human immune system can provide important theoretical and technical support for the clinic...
Oronsky, Bryan Larson, Christopher Hammond, Terese C Oronsky, Arnold Kesari, Santosh Lybeck, Michelle Reid, Tony R
Published in
Clinical reviews in allergy & immunology
Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity, which involves persistent physical, medical, and cognitive sequelae following COVID-19, including persistent immunosuppression as well as pulmonary, cardiac, and vascular fibrosis. Pathologic fibrosis of organs and vasculature leads to increased mortality and se...
Laino, Maria Elena Ammirabile, Angela Motta, Francesca De Santis, Maria Savevski, Victor Francone, Marco Chiti, Arturo Mannelli, Lorenzo Selmi, Carlo Monti, Lorenzo
...
Published in
Clinical reviews in allergy & immunology
The cardiovascular system is frequently affected by coronavirus disease-19 (COVID-19), particularly in hospitalized cases, and these manifestations are associated with a worse prognosis. Most commonly, heart involvement is represented by myocarditis, myocardial infarction, and pulmonary embolism, while arrhythmias, heart valve damage, and pericardi...
Fiorentino, David F Casciola-Rosen, Livia
Published in
Clinical reviews in allergy & immunology
Several rheumatic diseases have a perplexing association with cancer. Unraveling this mysterious connection is likely to provide deeper understanding regarding mechanisms governing the onset of both autoimmunity and cancer immunity, in addition to providing clinicians much needed guidance around whom and when to screen for occult malignancy. System...
Hu, Mingli You, Zhengrui Li, You Huang, Bingyuan Cui, Nana Wang, Rui Wei, Yiran Li, Bo Liang, Jubo Liu, Qiaoyan
...
Published in
Clinical reviews in allergy & immunology
In autoimmune hepatitis (AIH), the persisting inflammation contributes to fibrosis progression, for which conventional biochemical markers manifest relatively unsatisfactory prediction. Herein, we assessed the value of serum CD48 (sCD48) as an indicator for inflammation and fibrosis in AIH type 1. The levels of sCD48 were detected first in an explo...
Gibson, Frederick Hanly, Ailish Grbic, Nicole Grunberg, Noah Wu, Muzhou Collard, Marianne Alani, Rhoda M
Published in
Clinical reviews in allergy & immunology
Epigenetics is the study of heritable, reversible gene expression patterns that do not originate from alterations in the DNA sequence. Epigenetic modifications influence gene expression patterns and include DNA methylation, histone modifications, and gene regulation via non-coding RNAs. While the study of epigenetics has been most broadly applied t...
Abu-Raya, Bahaa Reicherz, Frederic Lavoie, Pascal M
Published in
Clinical reviews in allergy & immunology
The highest morbidity and mortality from respiratory syncytial virus (RSV) infection occurs in young infants. Immunization of expectant mothers during pregnancy has the potential to substantially reduce the burden of RSV disease in a majority of infants. Correlates of protection (COP) are important in guiding the development of maternal RSV vaccine...