von Kaeppler, Ericka P Wang, Qian Raghu, Harini Bloom, Michelle S Wong, Heidi Robinson, William H
Published in
Clinical immunology (Orlando, Fla.)
Osteoarthritis (OA), the leading cause of joint failure, is characterized by breakdown of articular cartilage and remodeling of subchondral bone in synovial joints. Despite the high prevalence and debilitating effects of OA, no disease-modifying drugs exist. Increasing evidence, including genetic variants of the interleukin 4 (IL-4) and IL-4 recept...
Leija-Martínez, José J Del-Río-Navarro, Blanca E Sanchéz-Muñoz, Fausto Muñoz-Hernández, Onofre Hong, Enrique Giacoman-Martínez, Abraham Romero-Nava, Rodrigo Patricio-Román, Karla L Hall-Mondragon, Margareth S Espinosa-Velazquez, Dario
...
Published in
Clinical immunology (Orlando, Fla.)
Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in a...
Gasmi, Amin Peana, Massimiliano Pivina, Lyudmila Srinath, Shvetha Gasmi Benahmed, Asma Semenova, Yuliya Menzel, Alain Dadar, Maryam Bjørklund, Geir
Published in
Clinical immunology (Orlando, Fla.)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory tract virus that causes Coronavirus disease (COVID-19). The virus originated in Wuhan, China, in December 2019 and has spread across the globe to-date. The disease ranges from asymptomatic carriers to symptoms such as fever, sore throat, cough, lung infections, and in...
Talotta, Rossella
Published in
Clinical immunology (Orlando, Fla.)
van Oers, Nicolai S C Hanners, Natasha W Sue, Paul K Aquino, Victor Li, Quan-Zhen Schoggins, John W Wysocki, Christian A
Published in
Clinical immunology (Orlando, Fla.)
X-linked severe combined immunodeficiency (X-SCID) is a disorder of adaptive immunity caused by mutations in the IL-2 receptor common gamma chain gene resulting in deficiencies of T and natural killer cells, coupled with severe dysfunction in B cells. X-SCID is lethal without allogeneic stem cell transplant or gene therapy due to opportunistic infe...
Cooper, Nina Li, Yu-Tung Möller, Anette Schulz-Weidner, Nelly Sachs, Ulrich J Wagner, Franz Hackstein, Holger Wienzek-Lischka, Sandra Grüneberg, Marianne Wild, Martin K
...
Published in
Clinical immunology (Orlando, Fla.)
Individuals with the Bombay phenotype (Oh) in the ABO blood group system do not express the H, A, and B antigens but have no clinical symptoms. Bombay phenotype with clinical symptoms has been described in leukocyte adhesion deficiency type II (LAD II), a fucosylation disorder caused by mutations in SLC35C1. Only few LAD II patients have been descr...
Radin, Massimo Cecchi, Irene Rubini, Elena Foddai, Silvia Grazietta Barinotti, Alice Menegatti, Elisa Roccatello, Dario Sciascia, Savino
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Clinical immunology (Orlando, Fla.)
Antiphospholipid syndrome (APS) is the most common acquired thrombophilia. The clinical manifestations of APS are mainly vascular thrombosis (venous and/or arterial) and/or recurrent pregnancy morbidity with the concomitant persistent presence of antiphospholipid antibodies (aPL). Therefore, the goals of the treatment of patients with APS are reduc...
Perry, Daniel J Titov, Anton A Sobel, Eric S Brusko, Todd M Morel, Laurence
Published in
Clinical immunology (Orlando, Fla.)
This study performed an integrated analysis of the cellular and transcriptional differences in peripheral immune cells between patients with Systemic Lupus Erythematosus (SLE) and healthy controls (HC). Peripheral blood was analyzed using standardized flow cytometry panels. Transcriptional analysis of CD4+ T cells was performed by microarrays and N...
Zhang, Bo Liu, Limin Zhou, Tian Shi, Xiaoli Wu, Haijing Xiang, Zhongyuan Zhao, Ming Lu, Qianjin
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Clinical immunology (Orlando, Fla.)
Systemic lupus erythematosus (SLE) is a complex heterogenous autoimmune disease that can be challenging to diagnose. We previously identified the IFN-induced protein 44-like (IFI44L) methylation marker for SLE diagnosis, which can be detected by pyrosequencing. Although the previous technique has high sensitivity and specificity, it requires specia...
Phillips, Bradley G Wang, Ye Ambati, Suresh Ma, Ping Meagher, Richard B
Published in
Clinical immunology (Orlando, Fla.)
Obstructive Sleep Apnea (OSA) damages the health of 35% of adult Americans. Disordered sleep results in increased risk of several autoimmune disorders, but the molecular links to autoimmunity are poorly understood. Herein, we identified four cytokines associated with autoimmune disease, whose median serum levels were significantly different for OSA...
