Brown, Landon C Zhu, Jason Labriola, Matthew K Wu, Yuan Cheris, Sachica Liu, Xin Perkinson, Kathryn Su, Zuowei McCall, Shannon Huang, Jiaoti
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Published in
Clinical genitourinary cancer
Immune checkpoint inhibitors are now standard of care for many patients with metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC). Given real-world limitations in programmed death-ligand 1 (PD-L1) testing, concordance studies between PD-L1 assays are needed. We undertook comparisons of Dako 28-8 and Ventana SP142 assays ...
Roscigno, Marco Stabile, Armando Lughezzani, Giovanni Pepe, Pietro Galosi, Andrea Benedetto Naselli, Angelo Naspro, Richard Nicolai, Maria La Croce, Giovanni Aljoulani, Muhannad
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Published in
Clinical genitourinary cancer
The objective of this study was to test Prostate Imaging Reporting and Data System (PI-RADS) classification on multiparametric magnetic resonance imaging (mpMRI) and MRI-derived prostate-specific antigen density (PSAD) in predicting the risk of reclassification in men in active surveillance (AS), who underwent confirmatory or per-protocol follow-up...
Vannucchi, Margherita Minervini, Andrea Salvi, Matteo Montironi, Rodolfo Raspollini, Maria Rosaria
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Clinical genitourinary cancer
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms with unpredictable behavior. They are characterized by epithelioid cells, which stain with melanocytic markers, associated with spindle cells reactive for smooth muscle markers. PEComas may be sporadic or associated with the tuberous sclerosis complex, with mutations affe...
Rakic, Nikola Sood, Akshay Dalela, Deepansh Arora, Sohrab Malovana, Ulyana Keeley, Jacob Rogers, Craig Peabody, James Menon, Mani Abdollah, Firas
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Published in
Clinical genitourinary cancer
To examine the utilization of adjuvant radiotherapy (aRT) in contemporary prostate cancer patients with adverse pathological features at radical prostatectomy (RP). We identified 189,240 patients with adverse features at RP (positive margin, stage ≥pT3a, and/or pN1 disease), from 2004 to 2015, within the National Cancer Database, and validated our ...
Adashek, Jacob J Reed, Jarred P Tandon, Ankita Freedland, Stephen J Posadas, Edwin Bhowmick, Neil Chung, Leland W Freeman, Michael Figlin, Robert A Gong, Jun
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Published in
Clinical genitourinary cancer
The addition of docetaxel and abiraterone to androgen deprivation therapy (ADT) heralded a new era in the first-line treatment of metastatic castration-sensitive prostate cancer (mCSPC). Following the success of these combination regimens, 3 new trials presented data on using enzalutamide or apalutamide in men with mCSPC, which showed similar succe...
Patel, Sunil H Uzzo, Robert G Larcher, Alessandro Peyronnet, Benoit Lane, Brian R Pruthi, Deepak Reddy, Madhumitha Capitanio, Umberto Joshi, Shreyas Noyes, Sabrina
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Published in
Clinical genitourinary cancer
The efficacy of partial nephrectomy (PN) in setting of pT3a pathologic-upstaged renal cell carcinoma (RCC) is controversial. We compared oncologic and functional outcomes of radical nephrectomy (RN) and PN in patients with upstaged pT3a RCC. This was a multicenter retrospective analysis of patients with cT1-2N0M0 RCC upstaged to pT3a postoperativel...
Bellmunt Molins, Joaquim García-Donas Jiménez, Jesús Valderrama, Begoña P Virizuela Echaburu, Juan Antonio Hernando-Polo, Susana Climent Durán, Miguel Ángel Villa-Guzmán, José Carlos Arranz Arija, José Ángel Ostiategui, Mar Llorente Milagro, Nuria Laínez
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Published in
Clinical genitourinary cancer
The MAJA study compared vinflunine (VFL) plus best supportive care (BSC) maintenance therapy versus BSC alone in advanced urothelial carcinoma responsive to first-line chemotherapy. The primary end point of progression-free survival was achieved. We present the final overall survival (OS) and long-term follow-up safety analyses. Patients were enrol...
Yi, Zhenglin Liu, Renyu Hu, Jiao He, Tongchen Wang, Zihao Li, Yangle Zu, Xiongbing
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Clinical genitourinary cancer
Primary renal neuroendocrine neoplasms (NENs) are exceedingly rare. We used the Surveillance, Epidemiology, and End Results (SEER) data to summarize clinicopathologic characteristics, treatment outcomes, and prognostic factors of primary renal NENs. Data were identified from the SEER database. Clinicopathologic characteristics were compared by the ...
Hird, Amanda E Magee, Diana E Cheung, Douglas C Sander, Beate Sridhar, Srikala Nam, Robert K Kulkarni, Girish S
Published in
Clinical genitourinary cancer
Upper tract urothelial carcinoma (UTUC) is clinically understudied, and there are no definitive recommendations regarding timing of perioperative chemotherapy. The objective of this study was to compare 3 treatment pathways in UTUC: nephroureterectomy (NU) alone, neoadjuvant chemotherapy (NAC), and adjuvant chemotherapy (AC) using a microsimulation...
Kodiyan, Joyson Guirguis, Adel Ashamalla, Hani
Published in
Clinical genitourinary cancer
Radical prostatectomy with pelvic lymph node dissection (PLND) is the standard of care for unfavorable risk prostate cancer. We investigated dissection practice patterns and their impact on overall survival using a large national database. Men with prostate adenocarcinoma diagnosed between 2004 and 2013 were identified from the National Cancer Data...