Markowski, Mark C Kachhap, Sushant De Marzo, Angelo M Sena, Laura A Luo, Jun Denmeade, Samuel R Antonarakis, Emmanuel S
Published in
Clinical genitourinary cancer
Bipolar androgen therapy (BAT) is an emerging treatment strategy for men with metastatic castration resistant prostate cancer (mCRPC) whereby serum testosterone is cycled from supraphysiologic to near-castrate levels each month. BAT has been shown to induce clinical responses in a significant proportion of patients, some of which are extreme. We ex...
Alhalabi, Omar Hahn, Andrew W Msaouel, Pavlos Meric-Bernstam, Funda Wilson, Nathaniel Naing, Aung Piha-Paul, Sarina Janku, Filip Pant, Shubham Yap, Timothy A
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Published in
Clinical genitourinary cancer
Enrolling patients with metastatic urothelial carcinoma (mUC) in phase I trials provides an opportunity to identify biological drug activity. Developing prognostic scores may aid in patient selection for phase 1 trials. We analyzed records of patients with mUC who participated in targeted therapy and immunotherapy phase I clinical trials at MD Ande...
Leite, Katia Ramos Moreira Borges, Leonardo Lima Filho, Leopoldo Ribeiro Chade, Daher Coelho, Rafael Ferreira Cordeiro, Mauricio Srougi, Miguel Nahas, Willian Carlos
Published in
Clinical genitourinary cancer
Platinum-based neoadjuvant chemotherapy (NAC) in muscle-invasive urothelial bladder cancer (MIBC) has been adopted as a standard of care related to better survival outcomes. However, there is a considerable number of patients who do not respond, experiencing toxicity and delay in the surgical treatment. Our aim is to find biomarkers of response tha...
Ong, Wee Loon Milne, Roger L Foroudi, Farshad Millar, Jeremy L
Published in
Clinical genitourinary cancer
To evaluate the pattern of use of single-fraction conformal radiation therapy (SF-RT) and advanced radiation therapy techniques (ART), including stereotactic body radiation therapy (SBRT), for management of bone metastases (BM) in a population-based cohort of Australian men with prostate cancer (PCa) PATIENT AND METHODS: We reviewed men with metast...
Dorff, Tanya Shen, James Ruel, Nora Kittles, Rick Lyou, Yung Dandapani, Savita Wong, Jeff Wu, Huiqing Pal, Sumanta Lau, Clayton
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Published in
Clinical genitourinary cancer
Prostate cancer is the most commonly diagnosed cancer in American men, with striking differences between ethnic groups. Given the potential for lifestyle or genetic variations between subsets of Asian-American men to impact prostate cancer behavior, we sought to define the outcomes after radical prostatectomy among various Asian groups treated at a...
Costello, Brian A Bhavsar, Nrupen A Zakharia, Yousef Pal, Sumanta K Vaishampayan, Ulka Jim, Heather Fishman, Mayer N Molina, Ana M Kyriakopoulos, Christos E Tsao, Che-Kai
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Published in
Clinical genitourinary cancer
The Metastatic Renal Cell Carcinoma (MaRCC) Registry provides prospective data on real-world treatment patterns and outcomes in patients with metastatic renal cell carcinoma (mRCC). Patients with mRCC and no prior systemic therapy were enrolled at academic and community sites. End of study data collection was in March 2019. Outcomes included overal...
Curran, Catherine Adib, Elio Kazakova, Vera Grivas, Petros Diamantopoulos, Leonidas Nikolaos Alva, Ajjai Shivaram Su, Christopher Jain, Rohit K Tandon, Ankita Necchi, Andrea
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Published in
Clinical genitourinary cancer
Enfortumab vedotin (EV) is approved to treat metastatic urothelial carcinoma (mUC) following platinum and PD1/L1 inhibitors. Since the outcomes and patterns of therapy of patients following discontinuation of EV are unknown, we conducted a retrospective study to assess this issue. Data were retrospectively obtained from patients with mUC following ...
Kim, Joseph I Zhu, Denzel Barry, Emily Kovac, Evan Aboumohamed, Ahmed Agalliu, Ilir Sankin, Alex
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Clinical genitourinary cancer
The immune system plays an important role in the pathogenesis of Alzheimer disease (AD), but it remains unclear whether bacillus Calmette-Guérin (BCG) may affect the risk of AD or not. Using retrospective chart review, we collected data regarding demographics, comorbidities, cancer diagnosis, BCG treatment, and subsequent diagnosis of AD or other d...
Alessi, Sarah Maggioni, Roberta Luzzago, Stefano Colombo, Alberto Pricolo, Paola Summers, Paul E Saia, Giulia Manzoni, Marco Renne, Giuseppe Marvaso, Giulia
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Published in
Clinical genitourinary cancer
To investigate the use of apparent diffusion coefficient (ADC) values and other MRI features for predicting positive surgical margins (PSMs) in patients undergoing radical prostatectomy. We retrospectively identified 400 consecutive patients who underwent surgery for prostate cancer between January 2015 and June 2016. ADC values of the index lesion...
Bikkasani, Krishna Qin, Qian Zhong, Xiaobo Lin, Justin Galsky, Matthew D Oh, William K Tsao, Che-Kai
Published in
Clinical genitourinary cancer
Prostate-specific antigen (PSA) is a valuable prognostic and predictive biomarker in prostate cancer; however, the significance of PSA at or near the time of death is not well understood. This study aimed to characterize the significance of PSA at death in patients with metastatic castration-resistant prostate cancer (mCRPC). The Mount Sinai Genito...
