Peripheral Neuropathy-Time for Better Biomarkers?
Published in Clinical chemistry
Non-Parametric Combined Reference Regions and Prediction of Clinical Risk.
Published in Clinical chemistry
Many clinical decisions depend on estimating patient risk of clinical outcomes by interpreting test results relative to reference intervals, but standard application of reference intervals suffers from two major limitations that reduce the accuracy of clinical decisions: (1) each test result is assessed separately relative to a univariate reference...
Macrophage Sensors for Early Cancer Detection.
Published in Clinical chemistry
Diagnosis of Gestational Diabetes Mellitus Will Be Flawed until We Can Measure Glucose.
Published in Clinical chemistry
Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application.
Published in Clinical chemistry
One of the objectives for the liquid biopsy is to become a surrogate to tissue biopsies in diagnosis of cancer as a minimally invasive method, with clinical utility in real-time follow-ups of patients. To achieve this goal, it is still necessary to achieve a better understanding of the mechanisms of cancer and the biological principles that govern ...
Prospective Molecular Profiling of Circulating Tumor Cells from Patients with Melanoma Receiving Combinatorial Immunothe...
...Published in Clinical chemistry
BACKGROUND Blood molecular profiling of circulating tumor cells (CTCs) can enable monitoring of patients with metastatic melanoma during checkpoint inhibitor immunotherapy (CII) and in combination with targeted therapies. We developed a microfluidics-based CTC platform to explore CTC profiling utility in CII-treated patients with melanoma using a m...
Circulating microRNAs: In a Class of Their Own.
Published in Clinical chemistry
Simultaneous Detection of Gene Fusions and Base Mutations in Cancer Tissue Biopsies by Sequencing Dual Nucleic Acid Temp...
...Published in Clinical chemistry
Targeted next-generation sequencing is a powerful method to comprehensively identify biomarkers for cancer. Starting material is currently either DNA or RNA for different variations, but splitting to 2 assays is burdensome and sometimes unpractical, causing delay or complete lack of detection of critical events, in particular, potent and targetable...
To Be Taken in Count: Prostatic Tumor Cells Break Free upon Needle Biopsy.
Published in Clinical chemistry
Point-of-Care Testing in Microbiology: A Mechanism for Improving Patient Outcomes.
Published in Clinical chemistry
Increasingly, demands for improved health and quality of life conflict with the realities of delivering healthcare in an environment of higher expenditures, adherence to test utilization, and patient-centered experience. Patient-centered care is commonly identified as a goal of healthcare delivery, and yet healthcare systems struggle with delivery ...
