Zhang, Qianqian Wang, Ge Sun, Dehui Lin, Wanying Yan, Tizhen Wu, Yuanjun Wu, Meiying Chen, Jianhong Zou, Shaomin Xie, Wenchun
...
Published in
Clinical chemistry
Traditional phenotype-based screening for β-globin variant and β-thalassemia using hematological parameters is time-consuming with low-resolution detection. Development of a MALDI-TOF-MS assay using alternative markers is needed. We constructed a MALDI-TOF-MS-based approach for identifying various β-globin disorders and classifying thalassemia majo...
Povilaitis, Sydney C Chakraborty, Ashish Kirkpatrick, Lindsey M Downey, Rachel D Hauger, Sarmistha B Eberlin, Livia S
Published in
Clinical chemistry
Rapid identification of bacteria is critical to prevent antimicrobial resistance and ensure positive patient outcomes. We have developed the MasSpec Pen, a handheld mass spectrometry-based device that enables rapid analysis of biological samples. Here, we evaluated the MasSpec Pen for identification of bacteria from culture and clinical samples. A ...
Kavsak, Peter A
Published in
Clinical chemistry
Palomaki, Glenn E Eklund, Elizabeth E Kloza, Edward M Lambert-Messerlian, Geralyn M
Published in
Clinical chemistry
Prenatal screening for common trisomies via cell-free (cfDNA) is usually implemented by technologies utilizing massively parallel sequencing, stringent environmental controls, complex bioinformatics, and molecular expertise. An alternative and less complex methodology utilizes rolling circle amplification (RCA). Further evaluation of its performanc...
Myhre, Peder L Prescott, Margaret F Claggett, Brian Felker, G Michael Butler, Javed Piña, Ileana L Maisel, Alan S Williamson, Kristin M Ward, Jonathan H Solomon, Scott D
...
Published in
Clinical chemistry
Several different B-type natriuretic peptide (BNP) assays are used clinically for diagnostic and prognostic evaluation of heart failure (HF). BNP binds weakly to neprilysin and is cleaved in multiple areas adjacent to the binding sites for the antibodies used in these immunoassays. We assessed the changes in BNP following neprilysin inhibition as m...
Sikaris, Kenneth A
Published in
Clinical chemistry
Noel, Maxence Chasman, Daniel I Mora, Samia Otvos, James D Palmer, Christopher D Parsons, Patrick J Smoller, Jordan W Cummings, Richard D Mealer, Robert G
Published in
Clinical chemistry
GlycA is a nuclear magnetic resonance (NMR) signal in plasma that correlates with inflammation and cardiovascular outcomes in large data sets. The signal is thought to originate from N-acetylglucosamine (GlcNAc) residues of branched plasma N-glycans, though direct experimental evidence is limited. Trace element concentrations affect plasma glycosyl...
Keller, Michael Charya, Ananth Andargie, Temesgen Agbor-Enoh, Sean
Published in
Clinical chemistry
Shaw, Leslie M Vanderstichele, Hugo Knapik-Czajka, Malgorzata Blennow, Kaj Trojanowski, John Q
Published in
Clinical chemistry
Darlix, Amélie Cayrefourcq, Laure Pouderoux, Stéphane Menjot de Champfleur, Nicolas Bievelez, Alexis Jacot, William Leaha, Cristina Thezenas, Simon Alix-Panabières, Catherine
Published in
Clinical chemistry
The diagnosis of breast cancer (BC)-related leptomeningeal metastases (LM) relies on the detection of tumor cells in cerebrospinal fluid (CSF) using conventional cytology (gold standard). However, the sensitivity of this technique is low. Our goal was to evaluate whether circulating tumor cell (CTC) detection in CSF using the CellSearch® system cou...
