Cartagena, Lorraine Colón McGuire, Kandace Zot, Patricija Pillappa, Raghavendra Idowu, Michael Robila, Valentina
Published in
Clinical breast cancer
Reducing the rate of margin positivity and reoperations remains a paramount goal in breast-conserving surgery (BCS). This study assesses the effectiveness of standard partial mastectomy with cavity shave margins (CSM) compared with partial mastectomy with selective margin resection (SPM), with regard to outcomes of the initial surgeries, re-excisio...
Zhao, Rui-Peng Li, Zhi Li, Chang Xu, Kang Zhen, Lin-Lin Song, Wei Shi, Jian-Hua
Published in
Clinical breast cancer
B and T lymphocyte attenuator (BTLA), an immunoinhibitory receptor, is shown to suppress the lymphocyte activation. Several studies addressed the relationship between the BTLA rs1982809 polymorphism and the risk of cancer. To identify the effects of this polymorphism on the risk of breast cancer (BC), this study examined Chinese women from China, J...
Martin Huertas, Roberto Fernández Abad, María Corral de la Fuente, Elena Serrano Domingo, Juan José Martínez Jáñez, Noelia
Published in
Clinical breast cancer
Amplification of human epidermal growth factor receptor 2 (HER2) occurs in around 25% of breast cancers and has been associated with aggressive disease. Here, we summarize published evidence on efficacy and prolonged responses with trastuzumab emtansine (T-DM1) after first-line trastuzumab plus pertuzumab and provide possible factors related to pro...
Takashima, Tsutomu Hara, Fumikata Iwamoto, Takayuki Uemura, Yukari Ohsumi, Shozo Yotsumoto, Daisuke Hozumi, Yasuo Watanabe, Takanori Saito, Tsuyoshi Watanabe, Ken-Ichi
...
Published in
Clinical breast cancer
The previous randomized phase 3 trial (SELECT BC) showed that S-1 as a first-line chemotherapy for metastatic breast cancer (MBC) is non-inferior to taxane with respect to overall survival. This study aimed to identify the usefulness of metabolism-related genes as predictive biomarkers for the response to S-1 compared with taxane using tumor tissue...
Han, Yiqun Wang, Jiayu Sun, Yanxia Yu, Pei Yuan, Peng Ma, Fei Fan, Ying Luo, Yang Zhang, Pin Li, Qing
...
Published in
Clinical breast cancer
Different clinicopathologic characteristics could contribute to inconsistent prognoses of small breast neoplasms (T1a/T1b). This study was done to conduct a retrospective analysis and establish a clinical prediction model to predict individual survival outcomes of patients with small carcinomas of the breast. Based on the Surveillance, Epidemiology...
Davis, John Jr Boughey, Judy C Hoskin, Tanya L Day, Courtney N Cheville, John C Piltin, Mara A Hieken, Tina J
Published in
Clinical breast cancer
Controversy exists regarding optimal management of the axilla in clinically node-negative (cN0) mastectomy patients with one or two positive sentinel lymph nodes (+SLNs). We evaluated the influence of frozen-section pathology on axillary management and recurrence. We studied cN0 breast cancer patients treated from 2008 to 2018 with mastectomy and S...
Sharma, Rishabha Deva Sharmin, Afroza Sinha, Aaditya Solomon, Ashley Huynh, Isabelle Alani, Azhar Nagarajakumar, Anupama Kasem, Abdul Doddi, Sudeendra
Published in
Clinical breast cancer
To determine if there is any correlation between the number of positive non-sentinel lymph nodes (NSLN) and the mRNA copy numbers of cytokeratin 19 receptor on one step nucleic acid amplification (OSNA) in the sentinel lymph node (SLN). An 8-year retrospective study of consecutive patients who had primary surgery and sentinel node biopsy for breast...
Wu, Jessie M Turashvili, Gulisa
Published in
Clinical breast cancer
The American Joint Committee on Cancer (AJCC) staging system is the reference standard for describing the extent of neoplastic disease on the basis of the size of primary tumor (T), and the presence of regional lymph node (N) involvement and distant metastasis (M). Multiple foci of invasive breast carcinoma may pose staging challenges to the report...
Salvatore, Stefano Nappi, Rossella E Casiraghi, Arianna Ruffolo, Alessandro F Degliuomini, Rebecca Parma, Marta Leone Roberti Maggiore, Umberto Athanasiou, Stavros Candiani, Massimo
Published in
Clinical breast cancer
Breast cancer (BC) is the most common female cancer worldwide. Menopausal symptoms are a well-known side effect in women with BC and have a significant negative impact on quality of life (QoL) and sexuality. Nowadays, hormonal replacement therapy and local estrogens are the most common prescriptions to treat vulvovaginal (VVA) symptoms. However, in...
Li, Xin Yan, Changjiao Xiao, Jingjing Xu, Xin Li, Yike Wen, Xinxin Wei, Hongliang
Published in
Clinical breast cancer
The breast-conserving surgery (BCS) rate for patients with breast cancer in China is much lower than that in Europe and the United States. This study aimed to identify factors affecting the choice of surgical modality following neoadjuvant chemotherapy (NAC) in patients with breast cancer in northwest China. Patients who underwent mastectomy or BCS...
