Santoni, Matteo Massari, Francesco Takeshita, Hideki Tapia, Jose Carlos Dionese, Michele Pichler, Renate Rizzo, Mimma Lam, Elaine T Grande, Enrique Kemp, Robert
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Published in
Clinical and experimental medicine
The ARON-2 study (NCT05290038) aimed to assess the real-world efficacy of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. This retrospective analysis reports the outcomes of urothelial carcinoma (UC) patients with bone metastases (BM). Medical records of patients with documented metastatic UC treated by pembroliz...
Zheng, Yonghui Shen, Guoshuang Zhang, Chengrong Huo, Xingfa Xin, Yuanfang Fang, Qianqian Guan, Yumei Zhao, Fuxing Ren, Dengfeng Liu, Zhen
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Published in
Clinical and experimental medicine
Anti-human epidermal growth factor receptor-2 (anti-HER2) therapy has shown excellent efficacy in patients with HER2 overexpression and amplification. Although HER2 mutations are rarely expressed in several cancers, when they occur, they can activate the HER2 signaling pathway. In recent years, studies have shown that anti-HER2 drugs have promising...
Zhang, Jiawei Zeng, Qun She, Meihua
Published in
Clinical and experimental medicine
LIM domain protein 2, also known as LIM protein FHL2, is a member of the LIM-only family. Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various proteins and plays a crucial role in regulating gene expression, cell growth, and signal transduction in muscle and cardiac tissue. In recent years, mounting evidence ha...
Chen, Ning-Chun Chang, Hung Kao, Hsiao-Wen Ou, Che-Wei Kuo, Ming-Chung Wang, Po-Nan Lin, Tung-Liang Wu, Jin-Hou Hung, Yu-Shin Su, Yi-Jiun
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Published in
Clinical and experimental medicine
Prognosis of diffuse large B cell lymphoma (DLBCL) can be predicted by various factors. The most widely used tool for prediction is the international prognostic index (IPI). β2-microglobulin is a tumor marker commonly used in hematological malignancies. β2-microglobulin is well correlated with outcome of DLBCL. It has been used as an adjunctive too...
Bosquillon de Jarcy, Laure Akbil, Bengisu Mhlekude, Baxolele Leyens, Johanna Postmus, Dylan Harnisch, Greta Jansen, Jenny Schmidt, Marie L Aigner, Annette Pott, Fabian
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Published in
Clinical and experimental medicine
Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP, displays broad antiviral activity. It reduces HIV-1 infectivity by interfering with Env maturation and virion incorporation, and increases survival of Influenza A virus-infected mice via antiviral innate immune signaling. Its antiviral potential in SARS-CoV-2 infection remains la...
Yang, Lin Zhao, Qiuling Chen, Ting Liu, Wenbin Qiu, Xiuliang Chen, Jincan Huang, Shengqiang Huang, Ruyi Dong, Liangliang
Published in
Clinical and experimental medicine
Anti-PD-1 immunotherapy has been widely applied in patients with some types of lymphoma. Classical Hodgkin's lymphoma (cHL) is highly sensitive to immunotherapy, but non-Hodgkin's lymphoma (NHL) does not show a good response. Studies have indicated that haematopoietic progenitor kinase 1 (HPK1) suppresses T cells and reduces antitumour immunity. Th...
Huang, Peng Wang, YuHan Zhang, PengFei Li, Qiu
Published in
Clinical and experimental medicine
Reversible protein ubiquitination represents an essential determinator of cellular homeostasis, and the ubiquitin-specific enzymes, particularly deubiquitinases (DUBs), are emerging as promising targets for drug development. DUBs are composed of seven different subfamilies, out of which ubiquitin-specific proteases (USPs) are the largest family wit...
Asperti, Michela Cantamessa, Luca Gryzik, Magdalena Bugatti, Mattia Codenotti, Silvia Denardo, Andrea Vermi, William Fanzani, Alessandro Poli, Maura
Published in
Clinical and experimental medicine
Rhabdomyosarcoma (RMS) is an aggressive rare neoplasm that derives from mesenchymal cells, which frequently develops resistance to the current therapies and the formation of metastases. Thus, new therapies are needed. The alteration of iron metabolism in cancer cells was effective in reducing the progression of many tumors but not yet investigated ...
Zhang, Youao Peng, Yongzheng Xia, Xu
Published in
Clinical and experimental medicine
Many studies have shown that gut microbiota is closely related to autoimmune diseases (ADs). Studies on gut microbiota and ADs have also increased significantly, but no bibliometric analysis has summarized the association between gut microbiota and ADs. This study aimed to conduct a bibliometric and visual analysis of published studies on gut micro...
Luo, Hai-Qing Huang, Yu-Meng Li, Jing Tang, Xu-Dong Chen, Ran Wang, Yan Ren, Jing Dai, Qiu-Qin Lan, Liu-Bo Chen, Jiang-Yan
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Published in
Clinical and experimental medicine
Omega-3 has been proposed as an antitumor substance that suppresses the growth and metastasis of multiple types of tumor cells, including lung cancer, but the specific mechanisms involved remain obscure. Our previous studies showed that the expression of chemokine ligand 18 was related to the migration and metastasis of non-small cell lung cancer. ...
