Li, Manhua Ke, Jing Wang, Qiuhong Qian, Hongyan Yang, Lei Zhang, Xunlei Xiao, Jinzhang Ding, Haifang Shan, Xiaohang Liu, Qingqing
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Published in
Clinical and experimental medicine
Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly increased in clinical GC tissues com...
Liu, Hailing Pan, Yunbao Meng, Shan Zhang, Wanggang Zhou, Fuling
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Clinical and experimental medicine
Multiple myeloma (MM) is a complex disease and is presently an incurable malignant plasma cell tumor. Although the introduction of proteasome inhibitor and the immunomodulators markedly improved the effect of myeloma therapy, most patients still suffer from relapse even with an initially effective therapy. Accumulating evidence suggests that immuno...
Tong, Shichao Liu, Ji Zhang, Changqing
Published in
Clinical and experimental medicine
Rheumatoid arthritis (RA) is a chronic disease affecting daily life of numerous patients, and uncontrolled proliferation of synovial fibroblasts plays vital role during the pathology of RA. Platelet-rich plasma (PRP), widely used in tissue regeneration and pain management, is rarely studied in RA. This study aims to investigate the effect of PRP on...
D'Alto, Michele Riccardi, Antonella Argiento, Paola Di Stefano, Ilaria Romeo, Emanuele Iacono, Agostino Mattera D'Andrea, Antonello Fasano, Serena Sanduzzi, Alessandro Bocchino, Marialuisa
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Published in
Clinical and experimental medicine
Undifferentiated connective tissue disease at risk for systemic sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc, is a condition characterized by Raynaud's phenomenon with serum SSc marker autoantibodies and/or typical capillaroscopic findings and unsatisfying classification criteria for the disease. The aim of the present s...
Bautista-Herrera, L A De la Cruz-Mosso, U Morales-Zambrano, R Villanueva-Quintero, G D Hernández-Bello, J Ramírez-Dueñas, M G Martínez-López, E Brennan-Bourdon, L M Baños-Hernández, C J Muñoz-Valle, J F
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Published in
Clinical and experimental medicine
Psoriatic arthritis (PsA) is an autoimmune inflammatory disease associated with psoriasis. The cause of this pathology is still unknown, but research suggests the diseases are caused by a deregulated cytokine production. MIF is a cytokine associated with immunomodulation of Th1, Th2, and Th17 cytokine profiles in inflammatory diseases. Based on thi...
Tahara, Tomomitsu Tahara, Sayumi Horiguchi, Noriyuki Kawamura, Tomohiko Okubo, Masaaki Yamada, Hyuga Yoshida, Dai Ohmori, Takafumi Maeda, Kohei Komura, Naruomi
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Published in
Clinical and experimental medicine
DNA methylation of leukocyte DNA has been proposed to be a biomarker for cancer that can be used to target patients for appropriate clinical implementation. We investigated IGF2 DMR and LINE1 methylation in the leukocyte DNA and their association with clinicopathological features and prognosis of gastric cancer (GC) patients. Methylation status of ...
Lin, Shuai Wang, Meng Liu, Xinghan Zhu, Wenge Guo, Yan Dai, Zhiming Yang, Pengtao Tian, Tian Dai, Cong Zheng, Yi
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Published in
Clinical and experimental medicine
Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs...
Vestita, Michelangelo Lospalluti, Lucia Giudice, Giuseppe Bonamonte, Domenico Rossiello, Ignazio Filoni, Angela
Published in
Clinical and experimental medicine
Pan, Yunbao Liu, Guohong Zhou, Fuling Su, Bojin Li, Yirong
Published in
Clinical and experimental medicine
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with epigenetic modifications being increasingly identified as important targets for cancer research. DNA methylation catalyzed by DNA methyltransferases (DNMTs) is one of the essential epigenetic mechanisms that control cell proliferation, apoptosis, differentia...
Omran, Dalia Yosry, Ayman Darweesh, Samar K Nabeel, Mohammed M El-Beshlawey, Mohammed Saif, Sameh Fared, Azza Hassany, Mohamed Zayed, Rania A
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Clinical and experimental medicine
Evaluation of liver fibrosis stage is crucial in the assessment of chronic HCV patients, regarding decision to start treatment and during follow-up. Our aim was to assess the validity of the enhanced liver fibrosis (ELF) score in discrimination of advanced stage of liver fibrosis in naïve chronic HCV patients. We prospectively evaluated liver fibro...
