Blum, Arnon Meerson, Ari Rohana, Hanan Jabaly, Hanin Nahul, Nahul Celesh, Dorina Romanenko, Olga Tamir, Snait
Published in
Clinical and experimental medicine
To test the hypothesis that microRNAs may play a role in diabetic retinopathy, we measured the levels of different markers [microRNAs, vascular endothelial growth factor (VEGF), nitric oxide (NO), and total antioxidant capacity (TAO)] in patients with type 2 diabetes mellitus (T2DM) and microvascular complications. Sixty-nine patients were recruite...
Peng, Yue Pei, Qiongfei Feng, Siqi Su, Ya Liu, Ruixi Yi, Qijian Guo, Pengfei
Published in
Clinical and experimental medicine
The purpose of this study was to examine the serum levels of fibroblast growth factor 21 (FGF21) in children with acute Kawasaki disease (KD) and to investigate its relationship with coronary artery lesions (CALs). Blood samples from 58 children with KD before intravenous immunoglobulin treatment and from 28 healthy children as control group were c...
Mytsyk, Yulian Borys, Yuriy Tumanovska, Lesia Stroy, Dmytro Kucher, Askold Gazdikova, Katarina Rodrigo, Luis Kruzliak, Peter Prosecky, Robert Urdzik, Peter
...
Published in
Clinical and experimental medicine
None of the currently investigated molecular markers demonstrated sufficient accuracy in prognostication of the renal cell carcinoma (RCC) oncologic outcomes; thus, none of them has been recommended for the application in the routine clinical practice. The role of miR-15a as a potential prognostic marker for RCC is still not unveiled. The aim of ou...
Xin, Feng Yao, Dong-Wei Fan, Li Liu, Jiu-Hua Liu, Xiao-Dong
Published in
Clinical and experimental medicine
Bladder cancer is the second most common urological cancer worldwide with low early diagnosis and high mortality. Since the time of diagnosis directly affects survival rate, early detection and precise biomarkers of bladder cancer are very important. Adenylate kinase 4 (AK4) is a key enzyme involved in cellular metabolism and multiple cancer develo...
Zhou, Fan Xu, Tingting Deng, Chunyan Yu, Haiyan Wang, Xiaodong
Published in
Clinical and experimental medicine
Thrombocytopenia is the second most common hematological disease during pregnancy and is mainly caused by gestational thrombocytopenia, immune thrombocytopenia, or preeclampsia/HELLP syndrome. This study aims to investigate the causes and pregnancy outcomes of thrombocytopenia in pregnancies with platelet counts below 50 × 109/L. We retrospectively...
Wen, Yaoan Chen, Yeda Duan, Xiaolu Zhu, Wei Cai, Chao Deng, Tuo Zeng, Guohua
Published in
Clinical and experimental medicine
The prognostic value of programed death-ligand 1 (PD-L1) in urothelial carcinoma (UC) has been assessed in previous studies, while the results remain controversial and heterogeneous. Therefore, we performed this meta-analysis to explore the prognostic effect of PD-L1 in patients with UC. PubMed, Embase and Web of Science were searched to identify t...
Jiang, Han-Ji Wang, Xiao-Xiao Luo, Bi-Fen Cong, Xu Jin, Qian Qin, Hong Zhang, Hai-Ying Kong, Xiang-Sha Wei, Lai Feng, Bo
...
Published in
Clinical and experimental medicine
Direct antiviral agents (DAAs) can eliminate hepatitis C virus rapidly and make chronic hepatitis C (CHC) curable. The changes in the innate immune system during treatment with DAAs are still in dispute. To investigate how the functions of natural killer (NK) cells change during and after treatment with DAAs in each NK cell subset. Thirteen CHC pat...
Tinti, Maria Giulia Carnevale, Vincenzo Inglese, Michele Molinaro, Francesca Bernal, Marco Migliore, Alberto De Cata, Angelo
Published in
Clinical and experimental medicine
Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality is 36.9%, despite the recent pr...
Alharbi, Azzah Thompson, Jonathan P Brindle, Nicholas P Stover, Cordula M
Published in
Clinical and experimental medicine
Septicaemia is an acute inflammatory reaction in the bloodstream to the presence of pathogen-associated molecular patterns. Whole blood stimulation assays capture endotoxin-induced formation of aggregates between platelets and leucocytes using flow cytometry. We wanted to assess extent of spontaneous aggregate formation in whole blood stimulation a...
Pankowska, Violetta Malkowski, Bogdan Wedrowski, Mateusz Wedrowska, Ewelina Roszkowski, Krzysztof
Published in
Clinical and Experimental Medicine
Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be a marker of the biological cha...