Goda, Satoshi Hayakawa, Seiichi Karakawa, Shuhei Okada, Satoshi Kawaguchi, Hiroshi Kobayashi, Masao
Published in
Clinical and experimental immunology
Autoimmune neutropenia (AIN) in childhood is characterized by chronic neutropenia and positivity for antineutrophil antibodies, resulting in the excessive destruction of neutrophils. In this study, we investigated the involvement of regulatory T cells (Tregs) in the pathogenesis of AIN in childhood. Tregs have been classified into three subpopulati...
Zayas-Santiago, A Díaz-García, A Nuñez-Rodríguez, R Inyushin, M
Published in
Clinical and experimental immunology
Many cancer types are intrinsically associated with specific types of amyloidosis, in which amyloid is accumulated locally inside tumors or systemically. Usually, this condition relates to the hyperproduction of specific amylogenic proteins. Recently, we found that the accumulation of amyloid beta (Aβ) peptide immunofluorescence is linked to glioma...
Scheurer, J Reisser, T Leithäuser, F Messmann, J J Holzmann, K Debatin, K-M Strauss, G
Published in
Clinical and experimental immunology
The immunosuppressant rapamycin (RAPA) inhibits mammalian target of rapamycin (mTOR) functions and is applied after allogeneic bone marrow transplantation (BMT) to attenuate the development of graft-versus-host disease (GVHD), although the cellular targets of RAPA treatment are not well defined. Allogeneic T cells are the main drivers of GVHD, whil...
Oras, A Quirant-Sanchez, B Popadic, D Thunberg, S Winqvist, O Heck, S Cwikowski, M Riemann, D Seliger, B Martinez Caceres, E
...
Published in
Clinical and experimental immunology
A group of European FOCIS Centers of Excellence adapted panels of the Human Immunophenotyping Consortium (HIPC) for whole blood analysis. Using four core panels [T/regulatory T cell/B/natural killer (T/Treg /B/NK) and myeloid cells] the main leukocyte populations were analyzed in a clinical-diagnostic setting in a harmonized manner across different...
Björkander, S Carvalho-Queiroz, C Hallberg, J Persson, J-O Johansson, M A Nussbaum, B Jenmalm, M C Nilsson, C Sverremark-Ekström, E
Published in
Clinical and experimental immunology
Alterations in the composition and reduced diversity of the infant microbiome are associated with allergic disease in children. Further, an altered microbiota is linked to immune dysregulation, including skewing of different T helper (Th) subsets, which is also seen in atopic individuals. The aim of this study was, therefore, to investigate the ass...
Thwaites, R S
Published in
Clinical and experimental immunology
Lingblom, C Andersson, K Wennerås, C
Published in
Clinical and experimental immunology
Galectin-10 is involved in the T cell suppressive activity of regulatory T cells and eosinophils alike. We have identified a subpopulation of T cell suppressive eosinophils that express CD16 on the surface and contain more galectin-10 compared with conventional CD16-negative eosinophils. Our main goal was to determine how the intracellular protein ...
Liang, Q Tong, L Xiang, L Shen, S Pan, C Liu, C Zhang, H
Published in
Clinical and experimental immunology
Semi-allogeneic embryos are not rejected by the maternal immune system due to maternal-fetal immune tolerance. Progesterone (P) receptor (PR)-expressing γδ T cells are present in healthy pregnant women. In the presence of P, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF), which can facilitate immu...
Wieczfinska, J Sitarek, P Kowalczyk, T Pawliczak, R
Published in
Clinical and experimental immunology
Bronchial asthma is believed to be provoked by the interaction between airway inflammation and remodeling. Airway remodeling is a complex and poorly understood process, and controlling it appears key for halting the progression of asthma and other obstructive lung diseases. Plants synthesize a number of valuable compounds as constitutive products a...
Long, Y Zhao, X Liu, Chang Xia, C Liu, Chen
Published in
Clinical and experimental immunology
Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1+ and ICOS+ PD-1+ Tfh subsets w...
