Shavit, R Maoz-Segal, R Frizinsky, S Haj-Yahia, S Offengenden, I Machnas-Mayan, D Tunisky, Y Iancovici-Kidon, M Agmon-Levin, N
Published in
Clinical and experimental immunology
Primary immunodeficiency disorders (PID) are a group of heterogeneous disorders characterized by recurrent infections, autoimmunity, increased lymphoproliferative disorders and other malignancies. PID is classified into cellular or humoral disorders or a combination of both. We evaluated the clinical differences among adult patients with three vari...
Weckmann, M Thiele, D Liboschik, L Bahmer, T Pech, M Dittrich, A-M Fuchs, O Happle, C Schaub, B Ricklefs, I
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Published in
Clinical and experimental immunology
Levels of cytokines are used for in-depth characterization of patients with asthma; however, the variability over time might be a critical confounder. To analyze the course of serum cytokines in children, adolescents and adults with asthma and in healthy controls and to propose statistical methods to control for seasonal effects. Of 532 screened su...
Krishnan, S O'Boyle, C Smith, C J Hulme, S Allan, S M Grainger, J R Lawrence, C B
Published in
Clinical and experimental immunology
Systemic immune changes following ischaemic stroke are associated with increased susceptibility to infection and poor patient outcome due to their role in exacerbating the ischaemic injury and long-term disability. Alterations to the abundance or function of almost all components of the immune system post-stroke have been identified, including lymp...
El Hawary, R Meshaal, S Mauracher, A A Opitz, L Abd Elaziz, D Lotfy, S Eldash, A Boutros, J Galal, N Pachlopnik Schmid, J
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Published in
Clinical and experimental immunology
Severe combined immunodeficiency (SCID) is fatal if not treated with immune reconstitution. In Egypt, T- B+ SCID accounts for 38·5% of SCID diagnoses. An accurate genetic diagnosis is essential for choosing appropriate treatment modalities and for offering genetic counseling to the patient's family. The objectives of this study were to describe the...
Osada, A Matsumoto, I Mikami, N Ohyama, A Kurata, I Kondo, Y Tsuboi, H Ishigami, A Sano, Y Arai, T
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Clinical and experimental immunology
The citrullinated inter-alpha-trypsin inhibitor heavy chain 4 (cit-ITIH4) was identified as its blood level was associated with the arthritis score in peptide glucose-6-phosphate-isomerase-induced arthritis (pGIA) mice and the disease activity in patients with rheumatoid arthritis (RA). This study aimed to clarify its citrullination pathway and fun...
Tran, J Q Grover, D Zhang, M Stapels, M Brennan, R Bangari, D S Piepenhagen, P A Roberts, E Oliva, P Zubair, F
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Published in
Clinical and experimental immunology
Biological treatments such as enzyme-replacement therapies (ERT) can generate anti-drug antibodies (ADA), which may reduce drug efficacy and impact patient safety and consequently led to research to mitigate ADA responses. Transient low-dose methotrexate (TLD-MTX) as a prophylactic ITI regimen, when administered concurrently with ERT, induces long-...
Vukovic, N van Elsas, A Verbeek, J S Zaiss, D M W
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Clinical and experimental immunology
The clinical application of monoclonal antibodies (mAbs) has revolutionized the field of cancer therapy, as it has enabled the successful treatment of previously untreatable types of cancer. Different mechanisms play a role in the anti-tumour effect of mAbs. These include blocking of tumour-specific growth factor receptors or of immune modulatory m...
Halpert, G Halperin Sheinfeld, M Monteran, L Sharif, K Volkov, A Nadler, R Schlesinger, A Barshak, I Kalechman, Y Blank, M
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Published in
Clinical and experimental immunology
Despite undeniable improvement in the management of rheumatoid arthritis (RA), the discovery of more effective, less toxic and, ideally, less immune suppressive drugs are much needed. In the current study, we set to explore the potential anti-rheumatic activity of the non-toxic, tellurium-based immunomodulator, AS101 in an experimental animal model...
Halpert, G Katz, I Shovman, O Tarasov, S Ganina, K K Petrova, N Tocut, M Volkov, A Barshack, I Blank, M
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Published in
Clinical and experimental immunology
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease that leads to joint destruction and disability. Despite a significant progress in administration of biological agents for RA patients, there is still a need for improved therapy. Intravenous immunoglobulins (IVIG), a pooled polyspecific immunoglobulin (Ig)G extracted from 5000 ...
Del Pino Molina, L Torres Canizales, J M Pernía, O Rodríguez Pena, R Ibanez de Caceres, I López Granados, E
Published in
Clinical and experimental immunology
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia and different degrees of B cell compartment alteration. Memory B cell differentiation requires the orchestrated activation of several intracellular signaling pathways that lead to the activation of a number of factors, such as nuclear factor...
