Li, Keyi Guo, Qingbo Zhang, Xuedong Dong, Xinqian Liu, Wei Zhang, Anqi Li, Yingxue Yan, Jinqiang Jia, Guotao Zheng, Zheng
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Published in
Clinical and experimental immunology
Tertiary lymphoid structure (TLS) provides a local and critical microenvironment for both cellular and humoral immunity and supports effective antigen presentation and lymphocyte activation. However, the gene expression profile and prognostic significance of TLS in oral cancer remain largely unrevealed. In this study, we found the presence of both ...
Ivancic, R Iqbal, H deSilva, B Pan, Q Matrka, L
Published in
Clinical and experimental immunology
Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therapy used when surgery cannot cont...
Amodio, D Santilli, V Zangari, P Cotugno, N Manno, E C Rocca, S Rossi, P Cancrini, C Finocchi, A Chassiakos, A
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Published in
Clinical and experimental immunology
Generation of antigen-specific humoral responses following vaccination or infection requires the maturation and function of highly specialized immune cells in secondary lymphoid organs (SLO), such as lymph nodes or tonsils. Factors that orchestrate the dynamics of these cells are still poorly understood. Currently, experimental approaches that enab...
Gulli, F Napodano, C Marino, M Ciasca, G Pocino, K Basile, V Visentini, M Stefanile, A Todi, L De Spirito, M
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Published in
Clinical and experimental immunology
Several reports have highlighted the abnormal increments of serum immunoglobulin free light chains (FLCs) in the course of systemic autoimmune rheumatic diseases (SARD), but a comparative analysis among different conditions is still lacking. A strong association between elevated FLC and hepatitis C virus (HCV)-related mixed cryoglobulinaemia (HCVMC...
Peters, F S Peeters, A M A van den Bosch, T P P Mooyaart, A L van de Wetering, J Betjes, M G H Baan, C C Boer, K
Published in
Clinical and experimental immunology
Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here, we analysed genome-wide DNA methylation of circulating T cells of...
Bennett, F C Molofsky, A V
Published in
Clinical and experimental immunology
Mental illness exerts a major burden on human health, yet evidence-based treatments are rudimentary due to a limited understanding of the underlying pathologies. Clinical studies point to roles for the immune system in psychiatric diseases, while basic science has revealed that the brain has an active and multi-cellular resident immune system that ...
Chen, Z Deng, Y Li, F Xiao, B Zhou, X Tao, Z
Published in
Clinical and experimental immunology
Allergic rhinitis is thought to be an allergic disease associated with immunoglobulin (Ig)E-mediated immune response, characterized by increased T helper type 2 (Th2) cytokine production, elevated eosinophil levels in the nasal mucosa and induced nasal secretions. MicroRNA (miRNA) microarray data revealed that the expression level of miR-466a-3p wa...
Prucha, M Sedivy, P Stadler, P Zdrahal, P Prokopova, P Voska, L Sedlackova, L
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Clinical and experimental immunology
The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected...
Zhang, Y Jin, S
Published in
Clinical and experimental immunology
Anti-phospholipid syndrome (APS) is characterized by recurrent pathological pregnancy, arterial or venous thrombosis in the presence of anti-phospholipid antibody (aPL). Complement activation is recognized as an intermediate link leading to placental thrombosis and placental inflammation in APS model mice. Decay accelerating factor (DAF, CD55), MAC...
Sandor, A M Jacobelli, J Friedman, R S
Published in
Clinical and experimental immunology
Inhibition of immune cell trafficking to the pancreatic islets during type 1 diabetes (T1D) has therapeutic potential, since targeting of T cell and B cell trafficking has been clinically effective in other autoimmune diseases. Trafficking to the islets is characterized by redundancy in adhesion molecule and chemokine usage, which has not enabled e...
