Passaro, A. Mancuso, P. Gandini, S. Spitaleri, G. Labanca, V. Guerini-Rocco, E. Barberis, M. Catania, C. Del Signore, E. de Marinis, F.
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Published in
Clinical and Translational Oncology
PurposeImmunotherapy is a new standard first-line treatment for non-small cell lung cancers (NSCLC) with high programmed cell death-ligand 1 (PD-L1) expression (≥ 50%) and second-line treatment regardless of PD-L1 status, though not all patients benefit from this approach. Much effort is ongoing to identify robust prognostic and predictive biomarke...
Alvarez-SanNicolas, J. Gracia-Alegria, I. Trullols-Tarrago, L. Peiro-Ibañez, A. Lamas-Gomez, C.
Published in
Clinical and Translational Oncology
PurposeSurvival in Ewing’s sarcoma (ES) has increased with the use of chemotherapy. Surgical techniques such as limb salvage (LS) have been developed. Survival and adverse events have been widely studied in general series of ES, but there are few specific series of ES cases treated by LS, despite this being the most commonly used (surgical) approac...
Remon, J. García-Campelo, R. de Álava, E. Vera, R. Rodríguez-Peralto, J. L. Rodríguez-Lescure, Á. Bellosillo, B. Garrido, P. Rojo, F. Álvarez-Alegret, R.
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Published in
Clinical and Translational Oncology
The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing considerably. The diagnosis of these genomic alterations can lead to tailored treatment at the onset of disease or on progression and to obtaining additional predictive information on immunotherapy efficacy. However, in up to 25% of ca...
Zhao, Y. Qiao, G. Wang, X. Song, Y. Zhou, X. Jiang, N. Zhou, L. Huang, H. Zhao, J. Morse, M. A.
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Published in
Clinical and Translational Oncology
BackgroundAdvanced non-small cell lung cancer (NSCLC) has remained challenging to treat effectively. This study aimed to investigate the clinical effects and safety of immunotherapy with dendritic cells and cytokine-induced killer cells (DC-CIK) administered with chemotherapy (CT) in this malignancy.MethodsWe have developed a new clinical trial des...
Calderon, C. Carmona-Bayonas, A. Beato, C. Ghanem, I. Hernandez, R. Majem, M. Rosa Diaz, A. Higuera, O. Mut Lloret, M. Jimenez-Fonseca, P.
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Published in
Clinical and Translational Oncology
IntroductionThis study analyzes the prevalence of malnutrition, depression, anxiety, and somatization and which factor has the biggest effect on quality of life (QoL) in individuals with resected cancer.MethodsA prospective study was conducted among 747 participants. Participants completed the EORTC-QLQ30, MST, and BSI-18 questionnaires.ResultsPrev...
Hui, L. Wu, H. Wang, T.-W. Yang, N. Guo, X. Jang, X.-J.
Published in
Clinical and Translational Oncology
PurposeThe purpose of our study was to investigate an underlying mechanism that hydrogen peroxide-induced mitophagy contributed to laryngeal cancer cells survivals under oxidative stress condition.MethodsTumor tissue and serum samples were collected from patients with laryngeal cancer. The Hep2 cell, a human laryngeal carcinoma cell, was used in in...
Bräutigam, E. Lampl, C. Track, C. Nieder, C. Pichler, J. Hammer, J. Geinitz, H.
Published in
Clinical and Translational Oncology
PurposeThe aim of this retrospective study was to evaluate survival outcomes in well-performing, mainly, young patients receiving a sequence of all available therapeutic options for relapsed glioblastoma, including re-irradiation.MethodsWe performed a retrospective analysis of 27 patients irradiated twice for glioblastoma between 2008 and 2016. In ...
Zhang, Y. Wang, X. Chen, T.
Published in
Clinical and Translational Oncology
BackgroundHuaier extract has been demonstrated to exhibit potent anti-tumor effects in various types of cancer cells. However, the clinical benefit of Huaier granule in breast cancer has not been reported. In this study, we aimed to evaluate the efficacy of Huaier granule in breast cancer patients.MethodsOur study included 284 breast cancer patient...
Zhang, X.-B. Yang, Y.-Y. Zeng, Y. Zeng, H.-Q. Fu, B.-B. Ko, C.-Y. Luo, X. Du, Y.-P. Chen, L.-D. Lai, Y.-T.
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Published in
Clinical and Translational Oncology
BackgroundObstructive sleep apnea (OSA) is associated with cancer incidence and mortality. The underlying mechanism is unclear. This study aims to evaluate the influence of intermittent hypoxia (IH), a novel hallmark of OSA, on tumor and to access the anti-tumor effect of endostatin on a mouse model with OSA.MethodsThe C57BL/6 J mice were randomly ...
Grávalos, C. Sanmartín, O. Gúrpide, A. España, A. Majem, M. Suh Oh, H. J. Aragón, I. Segura, S. Beato, C. Botella, R.
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Published in
Clinical and Translational Oncology
Progress in the understanding of many tumors has enabled the development of new therapies, such as those targeted at specific molecules involved in cell growth (targeted therapies) or intended to modulate the immune system (immunotherapy). However, along with the clinical benefit provided by these new treatments, new adverse effects have also appea...
