Cardoso‐Fernandes, António Blumenthal, Kimberly G. Chiriac, Anca Mirela Tarrio, Isabel Afonso‐João, David Delgado, Luís Fonseca, João Almeida Azevedo, Luís Filipe Sousa‐Pinto, Bernardo
Published in
Clinical and Translational Allergy
Background Patients with a penicillin allergy label tend to have worse clinical outcomes and increased healthcare use. Drug provocation tests (DPT) are the gold‐standard in the diagnostic workup of penicillin allergy, but safety concerns may hinder their performance. We aimed to assess the frequency of severe reactions following a DPT in patients w...
Farkas, Henriette Stobiecki, Marcin Peter, Jonny Kinaciyan, Tamar Maurer, Marcus Aygören‐Pürsün, Emel Kiani‐Alikhan, Sorena Wu, Adrian Reshef, Avner Bygum, Anette
...
Published in
Clinical and Translational Allergy
Background Berotralstat (BCX7353) is an oral, once‐daily inhibitor of plasma kallikrein recently approved for prevention of angioedema attacks in adults and adolescents with hereditary angioedema (HAE). The objective of this report is to summarize results from an interim analysis of an ongoing long‐term safety study of berotralstat in patients with...
Di Bona, Danilo Paoletti, Giovanni Chu, Derek K. Pepys, Jack Macchia, Luigi Heffler, Enrico Canonica, Giorgio Walter
Published in
Clinical and Translational Allergy
Background Observational comparative effectiveness studies in allergen immunotherapy (AIT) represent an important evidence source answering research questions that can be challenging to obtain from randomized controlled trials (RCTs), such as long‐term benefits of AIT, the effects on asthma prevention and the onset of new allergen sensitizations. H...
Bousquet, Jean Pfaar, Oliver Agache, Ioana Bedbrook, Anna Akdis, Cezmi A Canonica, G. Walter Chivato, Tomas Al‐Ahmad, Mona Abdul Latiff, Amir H Ansotegui, Ignacio J
...
Published in
Clinical and Translational Allergy
Amaral, Rita Jacinto, Tiago Malinovschi, Andrei Janson, Christer Price, David Fonseca, João A. Alving, Kjell
Published in
Clinical and Translational Allergy
Background Blood eosinophil (B‐Eos) count is an emerging biomarker in the management of respiratory disease but determinants of B‐Eos count besides respiratory disease are poorly described. Therefore, we aimed to evaluate the influence of non‐respiratory diseases on B‐Eos count, in comparison to the effect on two other biomarkers: fraction of exhal...
Li, Lisha Wang, Zixi Cui, Le Xu, Yingyang Guan, Kai Zhao, Bin
Published in
Clinical and Translational Allergy
Background Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the anaphylaxis risks related to different mAbs is essential for their appropriate and safe administration. This study aimed to evaluate the associations between different mAbs and anaphylactic reactions...
Becker, Sven Zieglmayer, Petra Canto, Gabriela Fassio, Filippo Yong, Patrick Acikel, Cengizhan Raskopf, Esther Steveling‐Klein, Esther Helen Allekotte, Silke Mösges, Ralph
...
Published in
Clinical and Translational Allergy
Background The World Allergy Organization and the European Academy of Allergy and Clinical Immunology recommend to perform product‐specific meta‐analyses for allergen‐specific immunotherapies because of the high degree of heterogeneity between individual products. This meta‐analysis evaluates the efficacy and safety of Glutaraldehyde‐modified and M...
Siekierzynska, Aleksandra Piasecka‐Kwiatkowska, Dorota Myszka, Aleksander Burzynska, Marta Sozanska, Barbara Sozanski, Tomasz
Published in
Clinical and Translational Allergy
Background Apple tree fruits ( Malus × domestica Borkh.) are a rich source of nutrients and nutraceuticals and are recommended as a part of the healthy, staple diet. However, apples could be also the cause of allergies including severe reactions. Allergies to fruits like apples are predominantly associated with pollinosis. In North and Central Eu...
Skypala, Isabel J. Asero, Ricardo Barber, Domingo Cecchi, Lorenzo Diaz Perales, Arazeli Hoffmann‐Sommergruber, Karin Pastorello, Elide A. Swoboda, Ines Bartra, Joan Ebo, Didier G.
...
Published in
Clinical and Translational Allergy
Background Discovered and described 40 years ago, non‐specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. Aim The aim of th...
Jin, Jing Gan, Kexin Zhao, Lan Jia, Huijuan Zhu, Yifan Li, Xiongwei Yang, Zhaowei Ye, Zhengwen Cao, Ke Wang, Zhiqiang
...
Published in
Clinical and Translational Allergy
Background Pru p 1 is a major allergen in peach and nectarine, and the different content in varieties may affect the degree of allergic reactions. This study aimed to quantify Pru p 1 levels in representative peach varieties and select hypoallergenic Pru p 1 varieties. Methods To obtain monoclonal and polyclonal antibodies, mice and rabbits, respec...
