Xu, Huijuan Zhong, Ren Wang, Kai Li, Xuerong Zhao, Yanxia Jiang, Jian Si, Shaoyong Sun, Lirong
Published in
Clinical and Applied Thrombosis/Hemostasis
This study was conducted to assess the levels of inflammatory factors and angiogenic factors in patients with severe hemophilia A and evaluate their diagnostic values for acute joint bleeding. This study included a total of 144 patients with severe hemophilia A. Of them, 66 had acute joint bleeding. Ninety healthy volunteers were recruited as contr...
Abdulqader, Aveen M. Raouf Mohammed, Ali Ibrahim Rachid, Shwan Ghoraishizadeh, Peyman Mahmood, Sarwar Noori
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Clinical and Applied Thrombosis/Hemostasis
Hemophilia A (HA) is a severe coagulation disorder affecting 1 in 5000 to 10 000 male births. In severe cases, the most deleterious large DNA rearrangements are inversions of intron 22 (Inv22) and intron 1 (Inv1) of the factor VIII (FVIII) gene. These account for 40% to 50% and 1% to 5% of all causative mutations, respectively. Nevertheless, no gen...
Gruber, Philipp Fluri, Felix Schweizer, Juliane Luft, Andreas Müller, Beat Christ-Crain, Mirjam Katan, Mira
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Clinical and Applied Thrombosis/Hemostasis
Objective: The aim of this study was to confirm previous observations that proenkephalin A (PENK-A) may serve as prognostic marker in the setting of acute ischemic stroke in a large stroke cohort. Methods: The plasma concentration of PENK-A was measured within 72 hours of symptom onset in 320 consecutively enrolled patients with stroke. The primary...
Yan, Bin Wang, Qi Du, Weipeng Zhai, Suping Gou, Chaoyang Hu, Tianxi Xia, Lijun Ruan, Changgeng Zhao, Yiming
Published in
Clinical and Applied Thrombosis/Hemostasis
von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD). The aim of this study was to investigate the association between VWF and the severity of coronary stenosis quantified by the Gensini score in acute myocardial infarction (AMI),...
Phan, Trung Brailovsky, Yevgeniy Fareed, Jawed Hoppensteadt, Debra Iqbal, Omer Darki, Amir
Published in
Clinical and Applied Thrombosis/Hemostasis
The aim of this study was to investigate the utility of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to predict all-cause mortality in patients presenting with acute pulmonary embolism (PE). Three hundred consecutive patients with acute PE between March 2016 and December 2018 were retrospectively analyzed. We iden...
Zahran, Asmaa M. Nafady, Asmaa Saad, Khaled Hetta, Helal F. Abdallah, Alam-Eldin M. Abdel-Aziz, Safwat M. Embaby, Mostafa M. Abo Elgheet, Amir M. Darwish, Sanaa F. Abo-Elela, Mohamed Gamil M.
...
Published in
Clinical and Applied Thrombosis/Hemostasis
Background: Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of hydroxyurea (HU) treatment on the value of NLR and some inflammatory mediators in SCD. Methods: The hematological parameters and clinical events were analyzed in 35 children with...
Celebi, Savas Celebi, Ozlem Ozcan Berkalp, Berkten Aydogdu, Sinan Amasyali, Basri
Published in
Clinical and Applied Thrombosis/Hemostasis
Blood group types are associated with coronary artery disease. However, data are scarce about the impact of blood group types on coronary collateral circulation. In this study, we aimed to investigate the relationship between the blood group types and coronary collateral circulation. Two hundred and twelve patients who underwent coronary angiograph...
Shih, Ming-Yang Wang, Jiaan-Der Yin, Jia-De Tsan, Yu-Tse Chan, Wei-Cheng
Published in
Clinical and Applied Thrombosis/Hemostasis
There has been an ongoing debate as to whether hemophilia A (HA) is more severe than hemophilia B (HB), and there are studies supporting each side of the argument. The study aimed to investigate whether any differences in major bleeding events exist between patients with severe HA and HB. A nationwide, population-based retrospective cohort study us...
Hill, Nathan R. Sandler, Belinda Bergrath, Evelien Milenković, Dušan Ashaye, Ajibade O. Farooqui, Usman Cohen, Alexander T.
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Clinical and Applied Thrombosis/Hemostasis
There is no direct evidence comparing the 2 most commonly prescribed direct oral anticoagulants, apixaban and rivaroxaban, used for stroke prevention in nonvalvular atrial fibrillation (NVAF). A number of network meta-analyses (NMAs) of randomized control trials and real-world evidence (RWE) studies comparing the efficacy, effectiveness, and safety...
Siddiqui, Fakiha Tafur, Alfonso Bontekoe, Emily Iqbal, Omer Jeske, Walter Mehrotra, Siddharth Hoppensteadt, Debra Ramacciotti, Eduardo Fareed, Jawed
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Clinical and Applied Thrombosis/Hemostasis
Andexanet alfa is a recombinant factor Xa decoy protein, designed to reverse bleeding associated with oral anti-Xa agents. Andexanet alfa is also reported to neutralize the effects of heparin-related drugs. This study focused on the neutralization profiles of unfractionated heparin (UFH), enoxaparin, and, a chemically synthetic pentasaccharide, fon...
