Bakusic, J. Vrieze, E. Ghosh, M. Pizzagalli, D. A. Bekaert, B. Claes, S. Godderis, L.
Published in
Clinical Epigenetics
BackgroundThere is a growing interest in the role of brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in the pathways linked to anhedonia and reward learning on the one hand and cognitive performance, on the other hand. However, the epigenetic mechanisms behind this remain unkno...
Slot, Evelien Boers, Ruben Boers, Joachim van IJcken, Wilfred F. J. Tibboel, Dick Gribnau, Joost Rottier, Robbert de Klein, Annelies
Published in
Clinical Epigenetics
BackgroundAlveolar capillary dysplasia with or without misalignment of the pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with a variety of heterozygous genomic alterations in the FOXF1 gene or its 60 kb enhancer. Cases without a genomic alteration in the FOXF1 locus have been described as well. The mechanisms responsible...
Noberini, Roberta Savoia, Evelyn Oliva Brandini, Stefania Greco, Francesco Marra, Francesca Bertalot, Giovanni Pruneri, Giancarlo McDonnell, Liam A. Bonaldi, Tiziana
Published in
Clinical Epigenetics
BackgroundIncreasing evidence linking epigenetic mechanisms and different diseases, including cancer, has prompted in the last 15 years the investigation of histone post-translational modifications (PTMs) in clinical samples. Methods allowing the isolation of histones from patient samples followed by the accurate and comprehensive quantification of...
Maredia, Ashna Guzzardi, David Aleinati, Mohammad Iqbal, Fatima Khaira, Arshroop Madhu, Aiswarya Wang, Xuemei Barker, Alex J. McCarthy, Patrick M. Fedak, Paul W. M.
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Published in
Clinical Epigenetics
BackgroundThe dilation of the aorta that occurs as a consequence of a congenitally bicuspid aortic valve (BAV) is associated with a risk of dissection, aneurysm or rupture. With progressive aortopathy, surgery is often recommended, but current patient selection strategies have limitations. A blood-based assay to identify those who would most benefi...
Jacobs, An Güiza, Fabian Verlinden, Ines Dulfer, Karolijn Garcia Guerra, Gonzalo Joosten, Koen Verbruggen, Sascha C. Vanhorebeek, Ilse Van den Berghe, Greet
Published in
Clinical Epigenetics
BackgroundThe PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-term internalizing, externalizing and total emotional/behavioral problems in critically ill children, as observed 4 years later. Ear...
Basu, Amitava Tiwari, Vijay K.
Published in
Clinical Epigenetics
Epigenetic mechanisms are known to define cell-type identity and function. Hence, reprogramming of one cell type into another essentially requires a rewiring of the underlying epigenome. Cellular reprogramming can convert somatic cells to induced pluripotent stem cells (iPSCs) that can be directed to differentiate to specific cell types. Trans-diff...
Chan, David W. Lam, Wai-Yip Chen, Fushun Yung, Mingo M. H. Chan, Yau-Sang Chan, Wai-Sun He, Fangfang Liu, Stephanie S. Chan, Karen K. L. Li, Benjamin
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Published in
Clinical Epigenetics
BackgroundIn contrast to stable genetic events, epigenetic changes are highly plastic and play crucial roles in tumor evolution and development. Epithelial ovarian cancer (EOC) is a highly heterogeneous disease that is generally associated with poor prognosis and treatment failure. Profiling epigenome-wide DNA methylation status is therefore essent...
Marttila, Saara Viiri, Leena E. Mishra, Pashupati P. Kühnel, Brigitte Matias-Garcia, Pamela R. Lyytikäinen, Leo-Pekka Ceder, Tiina Mononen, Nina Rathmann, Wolfgang Winkelmann, Juliane
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Published in
Clinical Epigenetics
BackgroundNon-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how this methylation status associates with nc886 RNA expression. Furthermore, we investigated the associations between the nc886 methylation st...
Feng, Li-yuan Yan, Bing-bing Huang, Yong-zhi Li, Li
Published in
Clinical Epigenetics
BackgroundPrimary or acquired chemoresistance is a key link in the high mortality rate of ovarian cancer. There is no reliable method to predict chemoresistance in ovarian cancer. We hypothesized that specific methylation characteristics could distinguish chemoresistant and chemosensitive ovarian cancer patients.MethodsIn this study, we used 450 K ...
Duan, Kuaikuai Mayer, Andrew R. Shaff, Nicholas A. Chen, Jiayu Lin, Dongdong Calhoun, Vince D. Jensen, Dawn M. Liu, Jingyu
Published in
Clinical Epigenetics
BackgroundMajor depression has been recognized as the most commonly diagnosed psychiatric complication of mild traumatic brain injury (mTBI). Moreover, major depression is associated with poor outcomes following mTBI; however, the underlying biological mechanisms of this are largely unknown. Recently, genomic and epigenetic factors have been increa...
