Li, Jindong Jin, Chengyan Sun, Lihua Wang, Bin Hua, Peiyan Zhang, Yan
Published in
Clinical Epigenetics
ObjectiveAlthough esophageal squamous cell carcinoma (ESCC)-oriented mechanism has been widely explored, the integrated action of histone deacetylase 2 (HDAC2), microRNA (miR)-503-5p and C-X-C motif chemokine 10 (CXCL10) in ESCC has not been thoroughly explored. Thus, we performed the research to study the role of HDAC2/miR-503-5p/CXCL10 axis in ES...
Monasso, Giulietta S. Küpers, Leanne K. Jaddoe, Vincent W. V. Heil, Sandra G. Felix, Janine F.
Published in
Clinical Epigenetics
BackgroundCirculating folate, vitamin B12 and homocysteine concentrations during fetal development have been associated with health outcomes in childhood. Changes in fetal DNA methylation may be an underlying mechanism. This may be reflected in altered epigenetic aging of the fetus, as compared to chronological aging. The difference between gestati...
Dieckmann, Linda Lahti-Pulkkinen, Marius Kvist, Tuomas Lahti, Jari DeWitt, Peter E. Cruceanu, Cristiana Laivuori, Hannele Sammallahti, Sara Villa, Pia M. Suomalainen-König, Sanna
...
Published in
Clinical Epigenetics
BackgroundEpigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variabl...
Kruppa, Jochen Sieg, Miriam Richter, Gesa Pohrt, Anne
Published in
Clinical Epigenetics
BackgroundIn DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-values. M-values follow a normal distribution and help to detect differentially methylated CpG sites. As biological effect measures,...
Stomper, Julia Meier, Ruth Ma, Tobias Pfeifer, Dietmar Ihorst, Gabriele Blagitko-Dorfs, Nadja Greve, Gabriele Zimmer, Dennis Platzbecker, Uwe Hagemeijer, Anne
...
Published in
Clinical Epigenetics
An amendment to this paper has been published and can be accessed via the original article.
Cao, Jiali Wu, Qichang Huang, Yanru Wang, Lingye Su, Zhiying Ye, Huiming
Published in
Clinical Epigenetics
Congenital heart disease (CHD) is a common structural birth defect worldwide, and defects typically occur in the walls and valves of the heart or enlarged blood vessels. Chromosomal abnormalities and genetic mutations only account for a small portion of the pathogenic mechanisms of CHD, and the etiology of most cases remains unknown. The role of ep...
Ruan, Weimei Chen, Xu Huang, Ming Wang, Hong Chen, Jiaxin Liang, Zhixin Zhang, Jingtong Yu, Yanqi Chen, Shang Xu, Shizhong
...
Published in
Clinical Epigenetics
BackgroundCurrent non-invasive tests have limited sensitivities and lack capabilities of pre-operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and validate a urine-based DNA methylation assay as a clinically feasible test for improving BC detection and enabling pre-operative risk stratifications.MethodsA urine-bas...
Cho, Young-Dan Kim, Woo-Jin Ryoo, Hyun-Mo Kim, Hong-Gee Kim, Kyoung-Hwa Ku, Young Seol, Yang-Jo
Published in
Clinical Epigenetics
BackgroundThe Encyclopedia of DNA Elements (ENCODE) project has advanced our knowledge of the functional elements in the genome and epigenome. The aim of this article was to provide the comprehension about current research trends from ENCODE project and establish the link between epigenetics and periodontal diseases based on epigenome studies and s...
Shao, Keke Pu, Weilin Zhang, Jianfeng Guo, Shicheng Qian, Fei Glurich, Ingrid Jin, Qing Ma, Yanyun Ju, Shaoqing Zhang, Zhao
...
Published in
Clinical Epigenetics
BackgroundAberrant DNA methylation has been firmly established as a factor contributing to the pathogenesis of colorectal cancer (CRC) via its capacity to silence tumour suppressor genes. However, the methylation status of multiple tumour suppressor genes and their roles in promoting CRC metastasis are not well characterised.MethodsWe explored the ...
Bazzocco, Sarah Dopeso, Higinio Martínez-Barriocanal, Águeda Anguita, Estefanía Nieto, Rocío Li, Jing García-Vidal, Elia Maggio, Valentina Rodrigues, Paulo de Marcondes, Priscila Guimarães
...
Published in
Clinical Epigenetics
BackgroundCancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further investigation is required to systematically identify cancer driver genes regulated by promoter hypermethylation.ResultsUsing genom...
