Galli, Claudio Julicher, Paul Plebani, Mario
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
The diagnosis of hepatitis C virus (HCV) infection has been traditionally based on the detection of the host antibody response. Although antibody assays are available in different formats and are fairly accurate, they cannot distinguish between an ongoing infection with HCV replicative activity and a past infection where HCV has been cleared, spont...
Tsiakanikas, Panagiotis Kontos, Christos K. Kerimis, Dimitrios Papadopoulos, Iordanis N. Scorilas, Andreas
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Background: MicroRNAs (miRNAs) may function either as oncogenes or tumor suppressors and are heavily involved in the initiation and progression of cancer, and in metastasis of tumor cells. MicroRNA-28-5p (miR-28-5p) targets several cancer-related genes and is hence involved in cell proliferation, migration, invasion and epithelial-mesenchymal trans...
Jendrzejewski, Jarosław Obołończyk, Łukasz Leczycka, Martina Eva Utracka, Alicja Ciura, Przemysław Makowski, Waldemar Sworczak, Krzysztof
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Sheldon, Joanna
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Gruber, Aurélia Pacault, Mathilde El Khattabi, Laila Allach Vaucouleur, Nicolas Orhant, Lucie Bienvenu, Thierry Girodon, Emmanuelle Vidaud, Dominique Leturcq, France Costa, Catherine
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Background: To limit risks of miscarriages associated with invasive procedures of current prenatal diagnosis practice, we aim to develop a personalized medicine-based protocol for non-invasive prenatal diagnosis (NIPD) of monogenic disorders relying on the detection of paternally inherited mutations in maternal blood using droplet digital PCR (ddPC...
Zhang, Shulan Wu, Ziyan Zhang, Wen Zhao, Jiuliang Norman, Gary L. Zeng, Xiaofeng Zhang, Fengchun Li, Yongzhe
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Clinical Chemistry and Laboratory Medicine (CCLM)
Background: Increasing evidence has highlighted the role of non-criteria antiphospholipid antibodies (aPLs) as important supplements to the current criteria aPLs for the diagnosis of antiphospholipid syndrome (APS). In this retrospective study, we evaluated the clinical relevance of antibodies to phosphatidylserine/prothrombin (aPS/PT) in Chinese p...
Manso, Jacopo Pezzani, Raffaele Scarpa, Riccardo Gallo, Nicoletta Betterle, Corrado
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Autoimmune Addison’s disease (AAD) is the most frequent cause of adrenocortical insufficiency. The natural history of AAD usually comprises five consecutive stages with the first stage characterized by the increase of plasma renin consistent with the impairment of pars glomerulosa, which is usually the first affected layer of the adrenal cortex. We...
Kopkova, Alena Sana, Jiri Fadrus, Pavel Slaby, Ondrej
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells rele...
Plebani, Mario
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
In the last few decades, laboratory medicine has undergone monumental changes, and laboratory technology, which has made enormous advances, now has new clinical applications thanks to the identification of a growing number of biomarkers and risk factors conducive to the promotion of predictive and preventive interventions that have enhanced the rol...
Ilie, Marius Hofman, Véronique Leroy, Sylvie Cohen, Charlotte Heeke, Simon Cattet, Florian Bence, Coraline Lalvée, Salomé Mouroux, Jérôme Marquette, Charles-Hugo
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Background: Circulating tumor cells (CTCs) hold potential for noninvasive diagnosis, prognosis and prediction testing in non-small cell lung cancer (NSCLC) patients. Minimizing degradation or loss of CTCs is pivotal for detection and profiling of the low abundance and fragile CTCs, particularly in clinical trials. We prospectively investigated (NCT...
