Critical role of laboratory medicine in the global response to the COVID-19 pandemic
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Individualized metabolomics: opportunities and challenges
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The goal of advancing science in health care is to provide high quality treatment and therapeutic opportunities to patients in need. This is especially true in precision medicine, wherein the ultimate goal is to link disease phenotypes to targeted treatments and novel therapeutics at the scale of an individual. With the advent of -omics technologie...
Blood biochemical characteristics of patients with coronavirus disease 2019 (COVID-19): a systemic review and meta-analy...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objective Recently, there have been several studies on the clinical characteristics of patients with coronavirus disease 2019 (COVID-19); however, these studies have mainly been concentrated in Wuhan, China; the sample sizes of each article were different; and the reported clinical characteristics, especially blood biochemical indices, were quite d...
Variability between testing methods for SARS-CoV-2 nucleic acid detection 16 days post-discharge: a case report
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest ev...
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. Initial response to this pandemic involved the development, production, and distribution of diagnostic molecular assays at an unprecedented rate, leading to minimal validation requireme...
Validation of a chemiluminescent assay for specific SARS-CoV-2 antibody
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Faced with the COVID-19 pandemic and its impact on the availability and quality of both therapeutic and diagnostic methods, the Belgian authorities have decided to launch a procedure for additional evaluation of the performance of serological tests offered for sale on the national territory. This has been proposed with a double aim: (1) ...
Dynamic profile and clinical implications of hematological parameters in hospitalized patients with coronavirus disease ...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives As people across the world suffer from coronavirus disease 2019 (COVID-19), further studies are needed to facilitate evaluating the severity and prognosis of COVID-19 patients. In the study, we aimed to dissect the dynamic profile and clinical implications of hematological findings in hospitalized patients with COVID-19. Methods We retro...
Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Coronavirus disease 2019 (COVID-19) represents a new pandemic caused by severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2). A previous pooled analysis clearly identified elevated D-dimer levels as being associated with severity of COVID-19. Since then, several other studies have provided clearer support for this initial evidence. Ho...
COVID-19: progression of disease and intravascular coagulation – present status and future perspectives
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human societ...
Biosafety measures for preventing infection from COVID-19 in clinical laboratories: IFCC Taskforce Recommendations
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Coronavirus disease 2019 (COVID-19) is the third coronavirus outbreak that has emerged in the past 20 years, after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). One important aspect, highlighted by many global health organizations, is that this novel coronavirus outbreak may be especially hazardous to healthc...
