Clinical Chemistry Laboratory Medicine in the post-acute COVID-19 era
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Inadvertent omission of a specimen integrity comment – an overlooked post-analytical error
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Monoclonal whole IgG impairs both fibrin and thrombin formation: hemostasis and surface plasmon resonance studies
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Monoclonal gammopathies frequently associate with hemostatic alterations. Thrombotic events occur with high incidence particularly upon treatment, while in rarer cases hemorrhagic diathesis can be observed. The pathology of these tendencies could be caused by thrombocytopenia or hyperviscosity burden of circulating monoclonal antibodies....
Screening for sickle cell disease: focus on newborn investigations
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Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Drepanocytosis is a genetic disease relevant for its epidemiological, clinical and socio-economic aspects. In our country the prevalence is highly uneven with peaks in former malaria areas, but migration flows in recent years have led to significant changes. In this document we review the screening programs currently existing in Italy with particul...
Analytical performance specifications – moving from models to practical recommendations
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Outcome-based analytical performance specifications: current status and future challenges
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Analytical performance specifications (APS) based on outcomes refer to how ‘good’ the analytical performance of a test needs to be to do more good than harm to the patient. Analytical performance of a measurand affects its clinical performance. Without first setting clinical performance requirements, it is difficult to define how good analytically ...
The EFLM European Urinalysis Guideline 2023
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Background The EFLM Task and Finish Group Urinalysis has updated the ECLM European Urinalysis Guidelines (2000) on urinalysis and urine bacterial culture, to improve accuracy of these examinations in European clinical laboratories, and to support diagnostic industry to develop new technologies. Recommendations Graded recommendations were built in t...
Applying the Milan models to setting analytical performance specifications – considering all the information
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Analytical performance specifications (APS) are used for decisions about the required analytical quality of pathology tests to meet clinical needs. The Milan models, based on clinical outcome, biological variation, or state of the art, were developed to provide a framework for setting APS. An approach has been proposed to assign each measurand to o...
Acute myeloid leukemia with blue-green neutrophilic inclusions have different outcomes: two cases and review of the lite...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Report from the HarmoSter study: different LC-MS/MS androstenedione, DHEAS and testosterone methods compare well; howeve...
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Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Current liquid chromatography-tandem mass spectrometry (LC-MS/MS) applications for circulating androgen measurements are technically diverse. Previously, variable results have been reported for testosterone. Data are scarce for androstenedione and absent for dehydroepiandrosterone sulfate (DHEAS). We assessed the agreement of androstened...
