Mario Plebani turns 70
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Procalcitonin (PCT)-guided antibiotic stewardship in Asia-Pacific countries: adaptation based on an expert consensus mee...
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Introduction Recently, an expert consensus on optimal use of procalcitonin (PCT)-guided antibiotic stewardship was published focusing mainly on Europe and the United States. However, for Asia-Pacific countries, recommendations may need adaptation due to differences in types of infections, available resources and standard of clinical care. Methods P...
Programme for Harmonization to the International Scale in Latin America for BCR-ABL1 quantification in CML patients: fin...
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives The quantitation of BCR-ABL1 mRNA is mandatory for chronic myeloid leukemia (CML) patients, and RT-qPCR is the most extensively used method in testing laboratories worldwide. Nevertheless, substantial variation in RT-qPCR results makes inter-laboratory comparability hard. To facilitate inter-laboratory comparative assessment, an internat...
Faecal haemoglobin distributions by sex, age, deprivation and geographical region: consequences for colorectal cancer sc...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Faecal immunochemical tests for haemoglobin (FIT) are becoming widely used in colorectal cancer (CRC) screening and assessment of symptomatic patients. Faecal haemoglobin concentration (f-Hb) thresholds are used to guide subsequent investigation. We established the distributions of f-Hb in a large screening population by sex, age, depriv...
Stabilization patterns and variability of hs-CRP, NT-proBNP and ST2 during 1 year after acute coronary syndrome admissio...
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Details of the biological variability of high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and ST2 are currently lacking in patients with acute coronary syndrome (ACS) but are crucial knowledge when aiming to use these biomarkers for personalized risk prediction. In the current s...
Biotin interference: evaluation of a new generation of electrochemiluminescent immunoassays for high-sensitive troponin ...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Background Biotin is currently a matter of concern for laboratories using biotin-streptavidin-based immunoassays. Biotin interferences have been reported for high-sensitive troponin T (hsTnT) and thyroid-stimulating hormone (TSH) assays. We aimed to evaluate the new generation of hsTnT and TSH electrochemiluminescent immunoassays announced to be le...
Analytical evaluation of Reebio procalcitonin latex-enhanced immunoturbidimetric assay on the HITACHI Labospect 008AS
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Clinical risk assessment of biotin interference with a high-sensitivity cardiac troponin T assay
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Biotin >20.0 ng/mL (81.8 nmol/L) can reduce Elecsys® Troponin T Gen 5 (TnT Gen 5; Roche Diagnostics) assay recovery, potentially leading to false-negative results in patients with suspected acute myocardial infarction (AMI). We aimed to determine the prevalence of elevated biotin and AMI misclassification risk from biotin interference wi...
A continued method performance monitoring approach for the determination of pediatric renin samples – application within...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Background Plasma renin levels were determined in the academia-driven, EU-funded “Labeling of Enalapril from Neonates up to Adolescents” (LENA) project to evaluate its role in pediatric heart failure. Quality-controlled bioanalysis is crucial to ensure reliable data generation. However, a comprehensive bioanalytical quality control (QC) concept to ...
Electrophoretic α1-globulin for screening of α1-antitrypsin deficient variants
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Background Available screening procedures for the detection of α1-antitrypsin-deficient (AATD) mutations have suboptimal cost-effectiveness ratios. The aim in this study was to evaluate and compare the viability of a composite approach, primarily based on the α1-globulin fraction, in identifying AAT genetic analysis eligible patients against standa...
