Lynch, Kara L Zhou, Shuxia Kaul, Ravi Walker, Roger Wu, Alan H
Published in
Clinical chemistry
The SARS-CoV-2 virus has mutated and evolved since the inception of the COVID-19 pandemic bringing into question the future effectiveness of current vaccines and antibody therapeutics. With evolution of the virus updated methods for the evaluation of the immune response in infected and vaccinated individuals are required to determine the durability...
Haymond, Shannon Master, Stephen R
Published in
Clinical chemistry
Chen, Hui Li, Zhao Feng, Sheng Richard-Greenblatt, Melissa Hutson, Emily Andrianus, Stefen Glaser, Laurel J Rodino, Kyle G Qian, Jianing Jayaraman, Dinesh
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Published in
Clinical chemistry
High-sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen assays are desirable to mitigate false negative results. Limited data are available to quantify and track SARS-CoV-2 antigen burden in respiratory samples from different populations. We developed the Microbubbling SARS-CoV-2 Antigen Assay (MSAA) with smartphone re...
Berna, Amalia Z Odom John, Audrey R
Published in
Clinical chemistry
Starkly highlighted by the current COVID-19 pandemic, infectious diseases continue to have an outsized impact on human health worldwide. Diagnostic testing for infection can be challenging due to resource limitations, time constraints, or shortcomings in the accuracy of existing diagnostics. Rapid, simple diagnostics are highly desirable. There is ...
Hui, Lisa Knight, Marian Edlow, Andrea Homer, Caroline Danchin, Margie
Published in
Clinical Chemistry
Fretts, Amanda M Jensen, Paul N Hoofnagle, Andrew N McKnight, Barbara Sitlani, Colleen M Siscovick, David S King, Irena B Psaty, Bruce M Sotoodehnia, Nona Lemaitre, Rozenn N
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Published in
Clinical chemistry
Recent studies suggest that associations of ceramides (Cer) and sphingomyelins (SM) with health outcomes differ according to the fatty acid acylated to the sphingoid backbone. The purpose of this study was to assess associations of Cer and SM species with mortality. The study population included participants from the Cardiovascular Health Study (CH...
Alharbi, Hana Bennett, Michael J He, Miao Master, Stephen R Ganetzky, Rebecca D
Published in
Clinical chemistry
Halper-Stromberg, Eitan McCall, Chad M Haley, Lisa M Lin, Ming-Tseh Vogt, Samantha Gocke, Christopher D Eshleman, James R Stevens, Wendy Martinson, Neil A Epeldegui, Marta
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Published in
Clinical chemistry
Clonal immunoglobulin and T-cell receptor rearrangements serve as tumor-specific markers that have become mainstays of the diagnosis and monitoring of lymphoid malignancy. Next-generation sequencing (NGS) techniques targeting these loci have been successfully applied to lymphoblastic leukemia and multiple myeloma for minimal residual disease detect...
Chen, Junman Qiu, Tian Mauk, Michael G Fan, Yaguang Jiang, Yong Ying, Jianming Zhou, Qinghua Qiao, Youlin Bau, Haim H Song, Jinzhao
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Published in
Clinical Chemistry
Chang, Adrienne Mzava, Omary Lenz, Joan S Cheng, Alexandre P Burnham, Philip Motley, S Timothy Bennett, Crissa Connelly, John T Dadhania, Darshana M Suthanthiran, Manikkam
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Published in
Clinical Chemistry
Background Metagenomic sequencing of microbial cell-free DNA (cfDNA) in blood and urine is increasingly used as a tool for unbiased infection screening. The sensitivity of metagenomic cfDNA sequencing assays is determined by the efficiency by which the assay recovers microbial cfDNA vs host-specific cfDNA. We hypothesized that the choice of methods...
