Kemp Gudmundsdottir, Katrin Svennberg, Emma Friberg, Leif Hygrell, Tove Frykman, Viveka Al-Khalili, Faris Hijazi, Ziad Rosenqvist, Mårten Engdahl, Johan
Published in
Circulation
Guidelines have suggested screening for atrial fibrillation to enable early treatment and avoid downstream negative clinical events. We aimed to determine whether atrial fibrillation screening potentially enhanced by NT-proBNP (N-terminal pro-B-type natriuretic peptide) would reduce stroke or systemic embolism incidence compared with a control grou...
DeFilippis, Andrew P Abbott, J Dawn Herbert, Brandon M Bertolet, Marnie H Chaitman, Bernard R White, Harvey D Goldsweig, Andrew M Polonsky, Tamar S Gupta, Rajesh Alsweiler, Caroline
...
Published in
Circulation
The MINT trial (Myocardial Ischemia and Transfusion) raised concern for harm from a restrictive versus liberal transfusion strategy in patients with acute myocardial infarction (MI) and anemia. Type 1 and type 2 MI are distinct pathophysiologic entities that may respond differently to blood transfusion. This analysis sought to determine whether the...
Butt, Jawad H McMurray, John Jv Claggett, Brian L Jhund, Pardeep S Neuen, Brendon L Mc Causland, Finnian Desai, Akshay Lam, Carolyn Sp Pitt, Bertram Pfeffer, Marc A
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Published in
Circulation
Background: Kidney outcomes have been variably defined using non-standardized composite endpoints in key heart failure (HF) trials, thus introducing complexity in their interpretation and cross-trial comparability. We examined the effects of steroidal mineralocorticoid receptor antagonists (MRAs), the angiotensin receptor-neprilysin inhibitor (ARNI...
Suero-Abreu, Giselle Alexandra Sung, Lily Parakh, Anushri Ghoshhajra, Brian Neilan, Tomas G DeFaria Yeh, Doreen Hung, Yin P Cameron, Danielle B Bloom, Jordan P
Published in
Circulation
Lamy, André Sirota, Dmitry A Jacques, Frederic Poostizadeh, Ahmad Noiseux, Nicolas Efremov, Sergey Demers, Philippe Akselrod, Boris Wang, Chew Yin Arora, Rakesh C
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Published in
Circulation
Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared with intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranexamic acid reduces the risk of in-hospital seizure without incr...
Morrow, Andrew Young, Robin Abraham, George R Hoole, Stephen Greenwood, John P Arnold, Jayanth Ranjit El Shibly, Mohamed Shanmuganathan, Mayooran Ferreira, Vanessa Rakhit, Roby
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Published in
Circulation
Background: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, and health-related quality of life. The G allele of the noncoding single nucleotide polymorphism RS9349379 enhances expression of the endothelin-1 gene (EDN1) in human vascular cells, potentially in...
Collet, Carlos Munhoz, Daniel Mizukami, Takuya Sonck, Jeroen Matsuo, Hitoshi Shinke, Toshiro Ando, Hirohiko Ko, Brian Biscaglia, Simone Rivero, Fernando
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Published in
Circulation
Diffuse coronary artery disease affects the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiologic coronary artery disease patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict op...
Hoeper, Marius M Oerke, Britta Wissmüller, Max Leuchte, Hanno Opitz, Christian Halank, Michael Seyfarth, Hans-Juergen Baldus, Stephan Bauersachs, Johann Böhm, Michael
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Published in
Circulation
We assessed the efficacy and safety of tadalafil, a phosphodiesterase type 5 inhibitor, in patients with heart failure with preserved ejection fraction and combined postcapillary and precapillary pulmonary hypertension. In the double-blind PASSION study (Phosphodiesterase-5 Inhibition in Patients With Heart Failure With Preserved Ejection Fraction ...
Kandzari, David E Weber, Michael A Pathak, Atul Zidar, James P Saxena, Manish David, Shukri W Schmieder, Roland E Janas, Adam J Langer, Christopher Persu, Alexandre
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Published in
Circulation
Renal denervation (RDN) has demonstrated clinically relevant reductions in blood pressure (BP) among individuals with uncontrolled hypertension despite lifestyle intervention and medications. The safety and effectiveness of alcohol-mediated RDN have not been formally studied in this indication. TARGET BP I is a prospective, international, sham-cont...
Zhu, Yike Ackers-Johnson, Matthew Shanmugam, Muthu K Pakkiri, Leroy Sivappiragasam Drum, Chester Lee Chen, Yanpu Kim, Johnny Paltzer, Wyatt G Mahmoud, Ahmed I Tan, Wilson Lek Wen
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Published in
Circulation
Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by cardiomyocyte dedifferentiation (CMDD), wherein adult cardiomyocytes revert to a less matured state th...
