Khramchikhin, Andrey V Skryl'nikova, Mariya А Pavlyukova, Yuliya N Zarubaev, Vladimir V Esaulkova, Yana L Muryleva, Anna А Shmanyova, Nadezhda T Danagulyan, Gevorg G Ostrovskii, Vladimir А
Published in
Chemistry of heterocyclic compounds
3-{[(1-Methyl-1H-tetrazol-5-yl)imino]methyl}quinoline-2-thiol and 3-{[(2-methyl-2H-tetrazol-5-yl)imino]methyl}quinoline-2-thiol were synthesized. The sequence of the thiol-Michael reaction and the (aza)-Morita-Baylis-Hillman reaction yielded 4-[(1-methyl-1H-tetrazol-5-yl)amino]-2-phenyl-4H-thiopyrano[2,3-b]quinoline-3-carbaldehyde, 4-[(2-methyl-2H-...
Khomenko, Dmytro M Doroshchuk, Roman O Ohorodnik, Yulia M Ivanova, Hanna V Zakharchenko, Borys V Raspertova, Ilona V Vaschenko, Oleksandr V Dobrydnev, Alexey V Grygorenko, Oleksandr O Lampeka, Rostyslav D
...
Published in
Chemistry of heterocyclic compounds
An efficient approach to the gram-scale synthesis of 3(5)-substituted, 1,3- and 1,5-disubstituted 1,2,4-triazole-derived building blocks is described. The key synthetic precursors - 1,2,4-triazole-3(5)-carboxylates (20 examples, 35-89% yield) were prepared from readily available acyl hydrazides and ethyl 2-ethoxy-2-iminoacetate hydrochloride. Furth...
Belyakova, Yulia Yu. Radulov, Peter S.
Published in
Chemistry of Heterocyclic Compounds
A summary of approaches developed for the synthesis of stable cyclic aza-peroxides is presented.
Shuvalov, Vladislav Yu Chernenko, Sergei А Shatsauskas, Anton L Samsonenko, Anna L Dmitriev, Maksim V Fisyuk, Alexander S
Published in
Chemistry of heterocyclic compounds
The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline ...
Mikolaichuk, Olga V Zarubaev, Vladimir V Muryleva, Anna А Esaulkova, Yana L Spasibenko, Daria V Batyrenko, Alina А Kornyakov, Ilya V Trifonov, Rostislav Е
Published in
Chemistry of heterocyclic compounds
The reaction of 5-aryl-NH-tetrazoles with adamantan-1-ol in concentrated sulfuric acid proceeds regioselectively with the formation of the corresponding 2-adamantyl-5-aryl-2H-tetrazoles. Nitration of these compounds leads to 2-(adamantan-1-yl)-5-(3-nitroaryl)-2Htetrazoles. The structures and composition of the obtained novel 2-adamantyl-5-aryltetra...
Mamedov, Vakhid А. Zhukova, Nataliya А. Kadyrova, Milyausha S.
Published in
Chemistry of Heterocyclic Compounds
The review discusses the use of the Dimroth rearrangement in the synthesis of condensed pyrimidines which are key structural fragments of antiviral agents. The main attention is given to publications over the past 10 years. The bibliography includes 107 references.
Fedotov, Victor V. Rusinov, Vladimir L. Ulomsky, Evgeny N. Mukhin, Evgeny M. Gorbunov, Evgeny B. Chupakhin, Oleg N.
Published in
Chemistry of Heterocyclic Compounds
The review presents data on the synthesis as well as studies of biological activity of new derivatives of pyrimido[1,2- a ]benzimidazoles published over the last decade. The bibliography of the review includes 136 sources.
Simurova, Nataliia V. Maiboroda, Olena I.
Published in
Chemistry of Heterocyclic Compounds
The microreview summarizes data published since 2015 on the antiviral properties and synthesis of compounds containing the 1,2,4-triazole ring.
Koifman, Oskar I. Lebedeva, Natalia Sh. Gubarev, Yury A. Koifman, Mikhail O.
Published in
Chemistry of Heterocyclic Compounds
In this work, we analyze the latest data on the molecular docking of a range of SARS-CoV-2 proteins to protoporphyrin IX, verteporfin, and chlorin e6, as well as consider the prospects for using chlorins and porphyrins as agents for photoinactivation of the SARS2 virus.
Ostrovskii, Vladimir А. Danagulyan, Gevorg G. Nesterova, Olga M. Pavlyukova, Yulia N. Tolstyakov, Vladimir V. Zarubina, Olga S. Slepukhin, Pavel А. Esaulkova, Yana L. Muryleva, Anna А. Zarubaev, Vladimir V.
...
Published in
Chemistry of Heterocyclic Compounds
Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,...
