Hasan, Hiba Ali Abdulmalek, Emilia Rahman, Mohd Basyaruddin Abdul Shaari, Khozirah Binti Yamin, Bohari Mohd. Chan, Kim Wei
Published in
Chemistry Central Journal
BackgroundAlthough the development of antibiotic and antioxidant manufacturing, the problem of bacterial resistance and food and/or cosmetics oxidation still needs more efforts to design new derivatives which can help to minimize these troubles. Benzimidazo[1,2-c]quinazolines are nitrogen-rich heterocyclic compounds that possess many pharmaceutical...
Feng, Da Wei, Fenju Wang, Zhao Kang, Dongwei Zhan, Peng Liu, Xinyong
Published in
Chemistry Central Journal
BackgroundEtravirine (ETV) was approved as the second generation drug for use in individuals infected with HIV-1 in 2008 by the U.S. FDA with its unique antiviral activity, high specificity, and low toxicity. However, there are some shortcomings of the existing synthetic routes, such as the long reaction time and poor yield.ResultsThis article desc...
Mabrouk, Mokhtar Hammad, Sherin F. Abdelaziz, Mohamed A. Mansour, Fotouh R.
Published in
Chemistry Central Journal
Ligand exchange method is introduced as an alternative to Job’s and mole ratio methods for studying the stoichiometry of relatively weak metal complexes in solutions. The method involves adding varying amounts of a ligand (L) to an excess constant amount of a colored complex (MX) with appropriate stability and molar absorptivity. The absorbance of ...
Desta, Zelalem Yibralign Cherie, Desie Alemaw
Published in
Chemistry Central Journal
BackgroundThe extracts from the aerial parts of Portulaca quadrifida have been reported to show the total flavonoid content, antioxidant and antibacterial activities.ResultsOur results revealed that the total flavonoid content of methanol and chloroform extracts is 2.335 ± 0.0097 and 1.7312 ± 0.0082 mgQE/100 g respectively. The two extracts also sh...
McAdam, Kevin Enos, Trevor Goss, Carol Kimpton, Harriet Faizi, Arif Edwards, Steve Wright, Christopher Porter, Andrew Rodu, Brad
Published in
Chemistry Central Journal
Differences in health risks between different styles of smokeless tobacco products (STPs) have prompted interest in their relative levels of toxic chemicals. We report here the development of methods for the analysis of STPs for coumarin and for α-angelica lactone (α-AL), both of which have been included in various published lists of tobacco toxica...
Shah, Rashmi Verma, Prabhakar Kumar
Published in
Chemistry Central Journal
Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. It has been reported to p...
Lasekan, Ola Hussein, Fatma Khalifa
Published in
Chemistry Central Journal
BackgroundPineapple is highly relished for its attractive sweet flavour and it is widely consumed in both fresh and canned forms. Pineapple flavour is a blend of a number of volatile and non-volatile compounds that are present in small amounts and in complex mixtures. The aroma compounds composition may be used for purposes of quality control as we...
Mandal, Subhankar P. Garg, Aakriti Prabitha, P. Wadhwani, Ashish D. Adhikary, Laxmi Kumar, B. R. Prashantha
Published in
Chemistry Central Journal
BackgroundAn alarming requirement for finding newer antidiabetic glitazones as agonists to PPARγ are on its utmost need from past few years as the side effects associated with the available drug therapy is dreadful. In this context, herein, we have made an attempt to develop some novel glitazones as PPARγ agonists, by rational and computer aided dr...
Ji, Hong Cai, Jianghong Gan, Nana Wang, Zhaohua Wu, Liyang Li, Guorong Yi, Tao
Published in
Chemistry Central Journal
A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki–Miyaura c...
Gawad, Jineetkumar Bonde, Chandrakant
Published in
Chemistry Central Journal
Tuberculosis is an air-borne disease, mostly affecting young adults in their productive years. Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives. The required building block of imidazopyridine was synthesized from commercially available 5,5-diaminopyridine-3-ol followed by ...
