Dallabernardina, Pietro Frank Schuhmacher Seeberger, Peter H Pfrengle, Fabian
Published in
Chemistry - A European Journal
The mixed-linkage (1→3),(1→4)-d-glucan (MLG) specific glycosyl hydrolase lichenase is an important biochemical tool for the structural characterization of MLGs. It holds potential for application in the brewery, animal feed, and biofuel industries. Several defined MLG oligosaccharides obtained by automated glycan assembly are used to analyze the su...
Senf, Deborah Ruprecht, Colin de Kruijff, Goswinus H M Simonetti, Sebastian O Frank Schuhmacher Seeberger, Peter H Pfrengle, Fabian
Published in
Chemistry - A European Journal
Xylan-degrading enzymes are crucial for the deconstruction of hemicellulosic biomass, making the hydrolysis products available for various industrial applications such as the production of biofuel. To determine the substrate specificities of these enzymes, we prepared a collection of complex xylan oligosaccharides by automated glycan assembly. Seve...
Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...
Werner, Stefan Ebert, Helgard Lechner, Bob-Dan Lange, Frank Achilles, Anja Bärenwald, Ruth Poppe, Silvio Blume, Alfred Saalwächter, Kay Tschierske, Carsten
...
Published in
Chemistry - A European Journal
A novel class of bolapolyphile (BP) molecules are shown to integrate into phospholipid bilayers and self-assemble into unique sixfold symmetric domains of snowflake-like dendritic shapes. The BPs comprise three philicities: a lipophilic, rigid, π-π stacking core; two flexible lipophilic side chains; and two hydrophilic, hydrogen-bonding head groups...
Deborah Schmidt Frank Schuhmacher Andreas Geissner Peter H. Seeberger Fabian Pfrengle
Published in
Chemistry - A European Journal
Ai, Wen Yang, Xueyan Wu, Yunxiang Wang, Xuan Li, Yuanchao Yang, Yaxi Zhou, Bing
Published in
Chemistry - A European Journal
A Rh(III)-catalyzed procedure for the C7-selective C-H alkylation of various indolines with α-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N2 as the sole bypr...
Li, Qiang Liu, Lei Zhang, Shuai Xu, Meng Wang, Xueqin Wang, Chen Besenbacher, Flemming Dong, Mingdong
Published in
Chemistry - A European Journal
Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33-42 ). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results supp...
Bartual-Murgui, Carlos Akou, Amal Shepherd, Helena J Molnár, Gábor Real, J Antonio Salmon, Lionel Bousseksou, Azzedine
Published in
Chemistry - A European Journal
A study of the spin-crossover (SCO) behavior of the tridimensional porous coordination polymer {Fe(bpac)[Pt(CN)4]} (bpac=bis(4-pyridyl)acetylene) on adsorption of different mono- and polyhalobenzene guest molecules is presented. The resolution of the crystal structure of {Fe(bpac)[Pt(CN)4]}⋅G (G=1,2,4-trichlorobenzene) shows preferential guest site...
Islam, Saidul Aguilar, Juan A Powner, Matthew W Nilsson, Mathias Morris, Gareth A Sutherland, John D
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
In the context of prebiotic chemistry, one of the characteristics of mixed nitrogenous-oxygenous chemistry is its propensity to give rise to highly complex reaction mixtures. There is therefore an urgent need to develop improved spectroscopic techniques if onerous chromatographic separations are to be avoided. One potential avenue is the combinatio...
Magrez, Magaly Le Guen, Yann Baslé, Olivier Crévisy, Christophe Mauduit, Marc
Published in
Chemistry - A European Journal
