π–π Catalysis in Carbon Flatland—Flipping [8]Annulene on Graphene
Published in Chemistry - A European Journal
Yellow Emission from Low Coordination Site of Sr2SiO4:Eu2+, Ce3+: Influence of Lanthanide Dopants on the Electron Densit...
Published in Chemistry - A European Journal
Lanthanide doping through a crystal site engineering approach tunes the emission wavelength suitable for LED applications, but weak emission from low coordination sites remains a huge challenge. Herein the use of a sensitizer is reported to enhance the emission strength and unravel the crystallinity and phase, as this approach demands a large amoun...
Mixed-Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools To Determine the Substrate Sp...
Published in Chemistry - A European Journal
The mixed-linkage (1→3),(1→4)-d-glucan (MLG) specific glycosyl hydrolase lichenase is an important biochemical tool for the structural characterization of MLGs. It holds potential for application in the brewery, animal feed, and biofuel industries. Several defined MLG oligosaccharides obtained by automated glycan assembly are used to analyze the su...
Active Site Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Asse...
Published in Chemistry - A European Journal
Xylan-degrading enzymes are crucial for the deconstruction of hemicellulosic biomass, making the hydrolysis products available for various industrial applications such as the production of biofuel. To determine the substrate specificities of these enzymes, we prepared a collection of complex xylan oligosaccharides by automated glycan assembly. Seve...
Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity.
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
The amyloid beta peptide 42 (Aβ42) is an aggregation-prone peptide that plays a pivotal role in Alzheimer's disease. We report that a subtle perturbation to the peptide through a single chirality change at glutamate 22 leads to a pronounced delay in the β-sheet adoption of the peptide. This was accompanied by an attenuated propensity of the peptide...
Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...
Automated synthesis of arabinoxylan-oligosaccharides enables characterization of antibodies that recognize plant cell wa...
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
Monoclonal antibodies that recognize plant cell wall glycans are used for high-resolution imaging, providing important information about the structure and function of cell wall polysaccharides. To characterize the binding epitopes of these powerful molecular probes a library of eleven plant arabinoxylan oligosaccharides was produced by automated so...
Rhodium(III)- and iridium(III)-catalyzed C7 alkylation of indolines with diazo compounds.
Published in Chemistry - A European Journal
A Rh(III)-catalyzed procedure for the C7-selective C-H alkylation of various indolines with α-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N2 as the sole bypr...
Modulating aβ33-42 peptide assembly by graphene oxide.
Published in Chemistry - A European Journal
Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33-42 ). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results supp...
Highly efficient direct aerobic oxidative esterification of cinnamyl alcohol with alkyl alcohols catalysed by gold nanop...
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
The selective aerobic oxidation of cinnamyl alcohol to cinnamaldehyde, as well as direct oxidative esterification of this alcohol with primary and secondary aliphatic alcohols, were achieved with high chemoselectivity by using gold nanoparticles supported in a nanoporous semicrystalline multi-block copolymer matrix, which consisted of syndiotactic ...
