Kroeger, Asja A Karton, Amir
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Noncovalent interactions are an integral part of the modern catalysis toolbox. Although stronger noncovalent interactions such as hydrogen bonding are commonly the main driving force of catalysis, π-π interactions typically provide smaller additional stabilizations, for example, to afford selectivity enhancements. Here, it is shown computationally ...
Rajaboopathi Mani Gupta, Santosh Kumar Ghosh, Partha Sarathi Jiang, Huaidong
Published in
Chemistry - A European Journal
Lanthanide doping through a crystal site engineering approach tunes the emission wavelength suitable for LED applications, but weak emission from low coordination sites remains a huge challenge. Herein the use of a sensitizer is reported to enhance the emission strength and unravel the crystallinity and phase, as this approach demands a large amoun...
Ségaud, Nathalie De Thomasson, Constance Daverat, Caroline Sénéchal-David, Katell Dos Santos, Amandine Steinmetz, Vincent Maître, Philippe Rebilly, Jean-Noël Banse, Frédéric Olivia Reinaud
...
Published in
Chemistry - A European Journal
A heteroditopic ligand associated with a calix[6]arene scaffold bearing a tris(imidazole) coordinating site at its small rim and an amine/pyridine ligand at its large rim has been prepared, and its regioselective coordination to ZnII at the small rim and FeII in the amine/pyridine ligand has been achieved. The heterodinuclear complex obtained displ...
Dallabernardina, Pietro Frank Schuhmacher Seeberger, Peter H Pfrengle, Fabian
Published in
Chemistry - A European Journal
The mixed-linkage (1→3),(1→4)-d-glucan (MLG) specific glycosyl hydrolase lichenase is an important biochemical tool for the structural characterization of MLGs. It holds potential for application in the brewery, animal feed, and biofuel industries. Several defined MLG oligosaccharides obtained by automated glycan assembly are used to analyze the su...
Senf, Deborah Ruprecht, Colin de Kruijff, Goswinus H M Simonetti, Sebastian O Frank Schuhmacher Seeberger, Peter H Pfrengle, Fabian
Published in
Chemistry - A European Journal
Xylan-degrading enzymes are crucial for the deconstruction of hemicellulosic biomass, making the hydrolysis products available for various industrial applications such as the production of biofuel. To determine the substrate specificities of these enzymes, we prepared a collection of complex xylan oligosaccharides by automated glycan assembly. Seve...
Warner, Christopher J A Dutta, Subrata Foley, Alejandro R Raskatov, Jevgenij A
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
The amyloid beta peptide 42 (Aβ42) is an aggregation-prone peptide that plays a pivotal role in Alzheimer's disease. We report that a subtle perturbation to the peptide through a single chirality change at glutamate 22 leads to a pronounced delay in the β-sheet adoption of the peptide. This was accompanied by an attenuated propensity of the peptide...
Inthasot, Alex Brunetti, Emilio Lejeune, Manuel Menard, Nicolas Prangé, Thierry Fusaro, Luca Bruylants, Gilles Olivia Reinaud Luhmer, Michel Jabin, Ivan
...
Published in
Chemistry - A European Journal
The Huisgen thermal reaction between an organic azide and an acetylene was employed for the selective monofunctionalization of a X6 -azacryptand ligand bearing a tren coordinating unit [X6 stands for calix[6]arene and tren for tris(2-aminoethyl)amine]. Supramolecular assistance, originating from the formation of a host-guest inclusion complex betwe...
Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...
Schmidt, Deborah Schuhmacher, Frank Geissner, Andreas Seeberger, Peter H Pfrengle, Fabian
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Monoclonal antibodies that recognize plant cell wall glycans are used for high-resolution imaging, providing important information about the structure and function of cell wall polysaccharides. To characterize the binding epitopes of these powerful molecular probes a library of eleven plant arabinoxylan oligosaccharides was produced by automated so...
Ai, Wen Yang, Xueyan Wu, Yunxiang Wang, Xuan Li, Yuanchao Yang, Yaxi Zhou, Bing
Published in
Chemistry - A European Journal
A Rh(III)-catalyzed procedure for the C7-selective C-H alkylation of various indolines with α-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N2 as the sole bypr...