Hetherington, Kristina Hegedus, Zsofia Edwards, Thomas A Sessions, Richard Nelson, Adam Wilson, Andrew John
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Protein-protein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptide based inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for function, yet, they do not predominantly populate the...
Gerken, Michael Turnbull, Douglas Wetmore, Stacey D Hazendonk, Paul
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Chemistry (Weinheim an der Bergstrasse, Germany)
The enhanced reactivity of [WF 5 ] + over WF 6 has been exploited to access a neutral derivative of elusive WF 5 . The reaction of WF 6 (NC 5 H 5 ) 2 with [(CH 3 ) 3 Si(NC 5 H 5 )][O 3 SCF 3 ] in CH 2 Cl 2 results in quantitative formation of trigonal-dodecahedral [WF 5 (NC 5 H 5 ) 3 ] + , which has been characterised as its [O 3 SCF 3 ] - salt by ...
Sun, Zhihua Lu, Lei Pan, Xiong Luo, Junhua
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Organic-inorganic metal halide perovskites (most notably CH 3 NH 3 PbI 3 ) have demonstrated remarkable physical attributes for photovoltaic and diverse optoelectronic applications, whereas the concerns on toxicity of the lead (Pb) content in chemical composition still motivate further exploration of new nontoxic candidates. Lead-free halide double...
Rustler, Karin Gomila, Alexandre Maleeva, Galyna Gorostiza, Pau Bregestovski, Piotr König, Burkhard
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Chemistry (Weinheim an der Bergstrasse, Germany)
Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABA A Rs) and displays full and reve...
Dagoneau, Dylan Wang, Qian Zhu, Jieping
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Chemistry (Weinheim an der Bergstrasse, Germany)
the strategy involving the use of functionalized tetrahydro-6H-cycloocta[b]indol-6-one is reported as a key intermediate for synthesis of members of the sarpagine-ajmaline-macroline family of monoterpene indole alkaloids. The desired tricycle was synthesized through the following key steps: 1) Evans' syn-selective aldolization; 2) Liebeskind-Srogl ...
Dardashti, Rebecca Notis Kumar, Shailesh Sternisha, Shawn M. Reddy, Post Sai Miller, Brian G. Metanis, Norman
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Chemistry (Weinheim an der Bergstrasse, Germany)
The design and synthesis of γ-selenolysine, a selenol-containing form of the commonly modified proteinogenic amino acid, lysine is reported. The utility of γ-selenolysine is demonstrated with the traceless ligation of the small ubiquitin-like modifier protein, SUMO-1, to a peptide segment of human glucokinase.
Bialy, Roger M Ali, Monsur M Li, Yingfu Brennan, John D
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Chemistry (Weinheim an der Bergstrasse, Germany)
We report a method to detect proteins via suppression of rolling circle amplification (RCA) by using an appropriate aptamer as the linear primer (denoted as an aptaprimer) to initiate RCA. In the absence of a protein target, the aptaprimer is free to initiate RCA, which can produce long DNA products that are detected via binding of a fluorescent in...
O'Hagan, David
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
This Review outlines the progression, primarily of our own work, but with important contributions from other labs, on the synthesis and properties of multiple vicinally fluorinated alkyl chains and rings. Chain conformations of individual diastereoisomers with -CHF- at adjacent carbons are influenced by stereoelectronic factors associated with the ...
Notaro, Anna Jakubaszek, Marta Koch, Severin Rubbiani, Riccardo Dömötör, Orsolya Enyedy, Éva A Dotou, Mazzarine Bedioui, Fethi Tharaud, Mickaël Goud, Bruno
...
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Cancer is one of the main causes of death worldwide. Chemotherapy, despite its severe side effects, is to date one of the leading strategies against cancer. Metal-based drugs present several potential advantages when compared to organic compounds and they have gained trust from the scientific community after the approval on the market of the drug c...
Xu, Jie Miyamoto, Shunichi Tojo, Sachiko Kawai, Kiyohiko
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Controlling the conformation and function of biomolecules through photoregulators holds great promise as a spatiotemporally controllable tool for disease control. In addition, introducing photoregulators into biomolecules has also found applications in constructing smart nanomaterials. In spite of the astonishing advances that have been made in the...
