Bold, Christian Paul Gut, Melanie Schürmann, Jasmine Lucena-Agell, Daniel Gertsch, Jürg Díaz, José Fernando Altmann, Karl-Heinz
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
We describe the convergent synthesis of three prototypical examples of a new class of analogues of the complex, cytotoxic marine macrolide (-)-zampanolide that incorporate an embedded N-substituted morpholine moiety in place of the natural tetrahydropyran ring. The final construction of the macrolactone core was based on a high-yielding intramolecu...
Kumar, Abhishek Semwal, Shrivats Choudhury, Joyanta
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Chemistry (Weinheim an der Bergstrasse, Germany)
The "hydricity" of a species refers to its hydride-donor ability. Similar to how the pKa is useful for determining the extent of dissociation of an acid, the hydricity plays a vital role in understanding hydride-transfer reactions. A large number of transition-metal-catalyzed processes involve the hydride-transfer reaction as a key step. Among thes...
Chen, Yuan Fu, Lulu Sun, Baobao Qian, Cheng Pangannaya, Srikala Zhu, Hong Ma, Jing Jiang, Juli Ni, Zhigang Wang, Ruibing
...
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Chemistry (Weinheim an der Bergstrasse, Germany)
Chiral α-amino acids play critical roles in the metabolic process in nearly all life forms. So far, chiral recognition of α-amino acids has mainly focused on the determination of l/d enantiomers. Herein, selection of planar chiral conformations between water-soluble pillar[5]arene WP5 and pillar[6]arene WP6 was observed due to α-side chain or ethyl...
Elahi, Syed Meheboob Raizada, Mukul Sahu, Pradip Kumar Konar, Sanjit
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Chemistry (Weinheim an der Bergstrasse, Germany)
Design, synthesis, and applications of metal-organic frameworks (MOFs) are among the most salient fields of research in modern inorganic and materials chemistry. As the structure and physical properties of MOFs are mostly dependent on the organic linkers or ligands, the choice of ligand system is of utmost importance in the design of MOFs. One such...
Mizuta, Satoshi Kitamura, Kanami Kitagawa, Ayako Yamaguchi, Tomoko Ishikawa, Takeshi
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Chemistry (Weinheim an der Bergstrasse, Germany)
Silver-promoted C-F bond formation in α-bromoamides by using AgF under mild conditions is reported. This simple method enables access to tertiary, secondary, and primary alkyl fluorides involving biomolecular scaffolds. This transformation is applicable to primary and secondary amides and shows broad functional-group tolerance. Kinetics experiments...
Pace, Kristen A Klepov, Vladislav V Berseneva, Anna A Zur Loye, Hans-Conrad
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Chemistry (Weinheim an der Bergstrasse, Germany)
Covalency in actinides has emerged as a resounding research topic on account of the technological importance in separating minor actinides from lanthanides for spent nuclear fuel processing, and utilization of their distinct bonding properties has been realized as a route towards overcoming this challenge. Because of the limited radial extent of th...
Ordoñez, Osvaldo Yu, Xiaojuan Wu, Guang Autschbach, Jochen Hayton, Trevor W
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Chemistry (Weinheim an der Bergstrasse, Germany)
Reaction of [UO2 Cl2 (THF)3 ] with 3 equivalents of LiC6 Cl5 in Et2 O resulted in the formation of first uranyl aryl complex [Li(Et2 O)2 (THF)][UO2 (C6 Cl5 )3 ] ([Li][1]) in good yields. Subsequent dissolution of [Li][1] in THF resulted in conversion into [Li(THF)4 ][UO2 (C6 Cl5 )3 (THF)] ([Li][2]), also in good yields. DFT calculations reveal that...
Sandvoß, Alexander Wiest, Johannes M
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted...
Aguillón, Anderson R Leão, Raquel A C Miranda, Leandro S M de Souza, Rodrigo O M A
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Chemistry (Weinheim an der Bergstrasse, Germany)
The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its phytotherapeutic research. Recently, some countries have included CBD as an antiepileptic product for compassionate use in children with refractory epilepsy. The growing demand for CBD has led to the ...
Özen, Bilal Fadaei Tirani, Farzaneh Schenk, Kurt Lin, Kun-Han Scopelliti, Rosario Corminboeuf, Clémence Frauenrath, Holger
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
The use of crystal engineering to control the supramolecular arrangement of π-conjugated molecules in the solid-state is of considerable interest for the development of novel organic electronic materials. In this study, we investigated the effect of combining of two types of supramolecular interaction with different geometric requirements, amide hy...
