Corrigendum: Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne–Azide Cycloadditions
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
Corrigendum: Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne–Azide Cycloadditions
Rapid and High‐Throughput SARS‐CoV‐2 RNA Detection without RNA Extraction and Amplification by Using a Microfluidic Bioc...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
Rapid, ultrasensitive, extraction‐free and amplification‐free strategy for the detection of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) RNA using a microfluidic biochip that exhibits an ultralow detection limit (600 copies mL−1) and the ability to simultaneously evaluate 15 RNA samples within 40 min. The proposed RNA detection stra...
A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern
...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
“ This study reports on a unique DNA aptamer, denoted MSA52, that displays a universally high affinity for the spike proteins of wildtype SARS‐CoV‐2 as well as the Alpha, Beta, Gamma, Epsilon, Kappa, Delta, and Omicron variants .” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202200078 ).
Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern (Chem. Eur...
...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
A unique DNA aptamer , denoted MSA52, displays universally high affinity for the spike proteins of the wild‐type SARS‐CoV‐2 as well as its Alpha, Beta, Gamma, Epsilon, Kappa, Delta and Omicron variants. This aptamer also recognizes pseudotyped lentiviruses expressing eight different spike proteins of SARS‐CoV‐2 with very high affinity, exhibiting d...
Cover Feature: Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers (Chem. Eur. J. 12/2022)
...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
Digital drug design reveals DNA aptamers binding SARS‐CoV‐2 : A hybrid in silico et vitro approach, structure and interaction‐based drug design, has been developed to create highly specific DNA aptamers for the receptor‐binding domain of the SARS‐CoV‐2 spike protein. The structure and binding affinity of the aptamers were validated by small‐angle X...
A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern
...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
This is a unique one : A unique DNA aptamer has been discovered that has the ability to recognize the spike proteins of the wildtype SARS‐CoV‐2 and its seven current variants of concern (VoCs), including B.1.1.7, B.1.351, P.1, B.1.429, B.1.617.1 B.1.617.2 and B.1.1.529 and is predicted to recognize the spike proteins of future VoCs.
Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers
...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
Applying computational methods together with experimental procedures can speed up aptamer design. By using a new iterative design procedure, structure and interaction‐based drug design (SIBDD), a highly specific aptamer to the receptor‐binding domain of the SARS‐CoV‐2 spike protein, was designed and validated. The approach combines molecular dynami...
Computational Insights into the Allosteric Effect and Dynamic Structural Features of the SARS-COV-2 Spike Protein.
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
COVID-19 caused by SARS-COV-2 is continuing to surge globally. The spike (S) protein is the key protein of SARS-COV-2 that recognizes and binds to the host target ACE2. In this study, molecular dynamics simulation was used to elucidate the allosteric effect of the S protein. Binding of ACE2 caused a centripetal movement of the receptor-binding doma...
Computational Insights into the Allosteric Effect and Dynamic Structural Features of the SARS‐COV‐2 Spike Protein
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
“ Our current research focuses on the molecular mechanism of toxicology and environmental behavior for selected pollutants .” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202104215 ).
Front Cover: Computational Insights into the Allosteric Effect and Dynamic Structural Features of the SARS‐COV‐2 Spike P...
Published in Chemistry (Weinheim an Der Bergstrasse, Germany)
Although the prefusion conformation of the spike protein of SARS‐COV‐2 can be stabilized alone, a spontaneously and energy‐friendly centripetal movement of the receptor binding domain occurs when spike protein binds to ACE2. During the binding process, several residues, especially Phe329 and Phe515, play a significant role in the allosteric effect....
