Atanasoff-Kardjalieff, Anna K Seidl, Bernhard Steinert, Katharina Daniliuc, Constantin G Schuhmacher, Rainer Humpf, Hans-Ulrich Kalinina, Svetlana Studt-Reinhold, Lena
Published in
Chembiochem : a European journal of chemical biology
Fusarium mangiferae causes the mango malformation disease (MMD) on young mango trees and seedlings resulting in economically significant crop losses. In addition, F. mangiferae produces a vast array of secondary metabolites (SMs), including mycotoxins that may contaminate the harvest. Their production is tightly regulated at the transcriptional lev...
Uno, Shinpei Harkiss, Alexander Chowdhury, Roy Caldwell, Stuart Prime, Tracy James, Andrew Gallagher, Brendan Prudent, Julien Hartley, Richard Murphy, Michael
...
Published in
Chembiochem : a European journal of chemical biology
The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred-fold within mitochondria in response to the mitochondrial membrane potential (Dym). Typically, a simple alkane links the TPP to its "cargo", increasing overall hydrophobi...
Higashi, Sayaka Imamura, Yuki Kikuma, Takashi Matoba, Takahiro Orita, Saya Yamaguchi, Yoshiki Ito, Yukishige Takeda, Yoichi
Published in
Chembiochem : a European journal of chemical biology
In the endoplasmic reticulum glycoprotein quality control system, UDP-glucose : glycoprotein glucosyltransferase (UGGT) functions as a folding sensor. Although it is known to form a heterodimer with selenoprotein F (SelenoF), the details of the complex formation remain obscure. A pulldown assay using co-transfected SelenoF and truncated mutants of ...
Yin, Lixin Zhou, Yang Hong, Sheng Ding, Feiqing Cai, Hui
Published in
Chembiochem : a European journal of chemical biology
Cancer vaccines are based on a vaccinology strategy whereby the patient's immune system is harnessed to induce a specific immune response to kill cancer cells and comprises two categories: prophylactic and therapeutic. Glycoprotein mucin 1 (MUC1), which is overexpressed and poorly glycosylated on cancer cells, is one of the most promising candidate...
Brown, Nathaniel W Schlomach, Sandra K Marmelstein, Alan M Fiedler, Dorothea
Published in
Chembiochem : a European journal of chemical biology
Protein phosphorylation is one of the most ubiquitous post-translational modifications, regulating numerous essential processes in cells. Accordingly, the large-scale annotation of phosphorylation sites continues to provide central insight into the regulation of signaling networks. The global analysis of the phosphoproteome typically relies on mass...
Ray, Devin M Flood, Julia R David, Yael
Published in
Chembiochem : a European journal of chemical biology
Biochemical studies of integral membrane proteins are often hampered by low purification yields and technical limitations such as aggregation causing in vitro manipulations to be challenging. The ability of controlling proteins in live cells bypasses these limitations while broadening the scope of accessible questions owing to the proteins being in...
Liu, Jing Li, Shu-Ming
Published in
Chembiochem : a European journal of chemical biology
Secondary metabolites derived from microorganism constitute an important part of natural products. Mining of the microbial genomes revealed a large number of uncharacterized biosynthetic gene clusters, indicating their greater potential to synthetize specialized or secondary metabolites (SMs) than identified by classic fermentation and isolation ap...
Lou, Jinchao Qualls, Megan L Best, Michael D
Published in
Chembiochem : a European journal of chemical biology
Liposomes are highly effective nanocarriers for encapsulating and delivering a wide range of therapeutic cargo. While advancements in liposome design have improved several pharmacological characteristics, an important area that would benefit from further progress involves cellular targeting and entry. In this concept article, we will focus on recen...
Jeong, Seoneun Lee, Kwonjung Yoo, Sung Hyun Lee, Hee-Seung Kwon, Sunbum
Published in
Chembiochem : a European journal of chemical biology
Metal-peptide networks (MPNs), which are assembled from short peptides and metal ions, are considered one of the most fascinating metal-organic coordinated architectures because of their unique and complicated structures. Although MPNs have considerable potential for development into versatile materials, they have not been developed for practical a...
Wu, Chuan-Shuo Cheng, Liang
Published in
Chembiochem : a European journal of chemical biology
Proteins are intriguing biomacromolecules for all living systems, not only as essential building blocks of organisms, but also as participants in almost every aspect of cellular activity such as metabolism and gene transcription/expression. Developing chemical biology tools that are capable of labeling/modifying proteins is a powerful method for de...
