Baker, Madelyn R Lee, Andrew S Rajadhyaksha, Anjali M
Published in
Channels (Austin, Tex.)
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not surprising given the work from multiple laboratories using cell and animal models that have established that Cav1.2 and Cav1.3 L-type calcium channels (LTCCs), encoded by CACNA1C a...
Kunzelmann, Karl Centeio, Raquel Ousingsawat, Jiraporn Talbi, Khaoula Seidler, Ursula Schreiber, Rainer
Published in
Channels (Austin, Tex.)
SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gained attention because of its modifier role in the gastrointestinal manifestation of cystic fibrosis (CF). SLC2...
Bibollet, Hugo Kramer, Audra Bannister, Roger A Hernández-Ochoa, Erick O
Published in
Channels (Austin, Tex.)
The CaV1.1 voltage-gated Ca2+ channel carries L-type Ca2+ current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle. Significant breakthroughs in the EC coupling field have often been close on the heels of technological advancement. In particular, CaV1.1 was the first voltage-gated Ca2+ channel to be cloned, the ...
Chai, Fangyu Zhang, Jingfang Fu, Tao Jiang, Peng Huang, Yichuan Wang, Lin Yan, Shu Yan, Xudong Yu, Longgang Xu, Zhen
...
Published in
Channels
SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of tumors. Unfortunately, the prognostic role of SLC2A3 in head and neck squamous cell carcinoma (HNSC) is less known. In the present study, we...
Spafford, J. David
Published in
Channels
One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion selectivity filter. The HFS+1 site is dubbed a “ beacon ” for its location at the entryway just above the ...
Lin, Wenfeng Xiong, Jiaqi Jiang, Yefan Liu, Hao Bian, Jinhui Wang, Juejin Shao, Yongfeng Ni, Buqing
Published in
Channels
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of MFS and to identify a potential effective target for attenu...
Heigl, Thomas Netzer, Michael A. Zanetti, Lucia Ganglberger, Matthias Fernández-Quintero, Monica L. Koschak, Alexandra
Published in
Channels
Cav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, CACNA1F , can cause congenital stationary night-blindness type 2 (CSNB2). Due to phenotypic variability in CSNB2, characterization of pathological variants is necessary to better ...
Xu, Pan Shao, Ru-Ru He, Yuan
Published in
Channels
TRPV1 channel is a sensitive ion channel activated by some noxious stimuli and has been reported to change many physiological functions after its activation. In this paper, we present a scientometric approach to explore the trends of the association between TRPV1 channel and inflammation and our goal is to provide creative directions for future res...
Page, Karen M Gumerov, Vadim M Dahimene, Shehrazade Zhulin, Igor B Dolphin, Annette C
Published in
Channels
In this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are present in all α2δ proteins. We have also included new data on the key function of these domains with respect to am...
Hussey, John W. Limpitikul, Worawan B. Dick, Ivy E.
Published in
Channels
Calcium ions (Ca2+) are the basis of a unique and potent array of cellular responses. Calmodulin (CaM) is a small but vital protein that is able to rapidly transmit information about changes in Ca2+ concentrations to its regulatory targets. CaM plays a critical role in cellular Ca2+ signaling, and interacts with a myriad of target proteins. Ca2+-de...
