Chang, Hyo Won Lee, MyungJin Lee, Yoon Sun Kim, Song Hee Lee, Jong Cheol Park, Jung Je Nam, Hae Yun Kim, Mi Ra Han, Myung Woul Kim, Seong Who
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Published in
Cellular signalling
The manner in which p53 maintains redox homeostasis and the means by which two key metabolic elements, glucose and glutamine, contribute to p53-dependent redox stability remain unclear. To elucidate the manner in which p53 deals with glucose-deprived, reactive oxygen species (ROS)-prone conditions in this regard, two isogenic cancer subclones (HN3R...
Smolgovsky, Sasha Ibeh, Udoka Tamayo, Tatiana Peña Alcaide, Pilar
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Cellular signalling
The fibrotic response has evolutionary worked in tandem with the inflammatory response to facilitate healing following injury or tissue destruction as a result of pathogen clearance. However, excessive inflammation and fibrosis are key pathological drivers of organ tissue damage. Moreover, fibrosis can occur in several conditions associated with ch...
Wang, Yan Dong, Tianfu Wang, Peishun Li, Shuqin Wu, Geng Zhou, Jun Wang, Zhiqi
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Cellular signalling
Breast cancer ranks as the major reason for mortality in women populations, accounting for 23% of all cancer deaths. One in every three Asian women encounters the risk of this cancer in their lifetime. Long intergenic non-coding RNAs (lincRNAs) have emerged as tumor promoters and suppressors. The molecular mechanism of breast cancer remains elusive...
Yaghoubi, Neda Zahedi Avval, Farnaz Khazaei, Majid Aghaee-Bakhtiari, Seyed Hamid
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Cellular signalling
Colorectal cancer (CRC) is a noticeable reason of cancer-associated deaths with a high incidence and mortality rate. Countless effort have been put into the improving clinical management of CRC patients including more effective tools and a wide variety of biomarkers for diagnostic, prognostic or predictive purposes. In recent years, dysregulated mi...
Chatterjee, Subhajit Sinha, Saptarshi Molla, Sefinew Hembram, Krushna Chandra Kundu, Chanakya Nath
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Cellular signalling
Concurrent use of DNA damaging agents with PARP inhibitors contribute to the effectiveness of the anticancer therapy. But there is a dearth of reports on the antiangiogenic effects of PARP inhibitors and the suppression of angiogenesis by this drug combination is not yet reported. For the successful development of cancer therapeutics, anti-cancer d...
Zheng, Donglin Li, Mengmeng Li, Guofei Hu, Jing Jiang, Xin Wang, Yabo Sun, Yuhua
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Cellular signalling
Temporal lobe epilepsy (TLE) is the most prevalent form of acquired epilepsy. Circular RNAs (circRNAs) have recently been highlighted as important regulators in TLE. Nevertheless, the role and mechanism of circRNA Drosha ribonuclease III (circ_DROSHA) in TLE pathogenesis are still unknown. Magnesium-free extracellular solution was used to establish...
Garvin, Alexandra M Khokhar, Bilal S Czubryt, Michael P Hale, Taben M
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Cellular signalling
Angiotensin II (Ang II) is a primary mediator of profibrotic signaling in the heart and more specifically, the cardiac fibroblast. Ang II-mediated cardiomyocyte hypertrophy in combination with cardiac fibroblast proliferation, activation, and extracellular matrix production compromise cardiac function and increase mortality in humans. Profibrotic a...
Velazquez, Fabiola N Hernandez-Corbacho, Maria Trayssac, Magali Stith, Jeffrey L Bonica, Joseph Jean, Bernandie Pulkoski-Gross, Michael J Carroll, Brittany L Salama, Mohamed F Hannun, Yusuf A
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Cellular signalling
Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and e...
Zhang, Yanyu Pisano, Michael Li, Nianhu Tan, Guoqing Sun, Fumou Cheng, Yan Zhang, Yanyan Cui, Xing
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Cellular signalling
Peripheral neuropathy (PN) is an incurable complication of multiple myeloma (MM) which adversely affects patients' quality of life. The important roles that Circular RNAs (circRNAs) play in tumor progression, and exosome-mediated intracellular communication has been recognized as a crucial factor in the pathogenesis of MM. However, the role of exos...
Wang, Yuehong Yu, Ruihuan Wu, Lingyun Yang, Guangdong
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Cellular signalling
Recognized as a novel and important gasotransmitter, hydrogen sulfide (H2S) is widely present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H2S has been shown to regulate oxidative stress and lipid metabolism. The aim of the present study is to examine the role of H2S in ferroptosis and lipid peroxidation in mouse myoblasts...
