Campos, Glenda V de Souza, Aline M A Ji, Hong West, Crystal A Wu, Xie Lee, Dexter L Aguilar, Brittany L Forcelli, Patrick A de Menezes, Rodrigo C Sandberg, Kathryn
...
Published in
Cellular and molecular neurobiology
Women who have bilateral oophorectomies prior to the age of natural menopause are at increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type disorders. Clinical and animal studies indicate angiotensin type 1 receptor (AT1R) blockers (ARBs) have blood pressure (BP)-independent neuroprotective effects. To investiga...
Wu, Ziyi Zhang, Yi Zhang, Yinong Zhao, Ping
Published in
Cellular and molecular neurobiology
Sevoflurane is a widely used inhalational anesthetic in pediatric medicine that has been reported to have deleterious effects on the developing brain. Strategies to mitigate these detrimental effects are lacking. Sirtuin 2 (SIRT2) is a member of nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases involved in a wide range of path...
Kadir, Rais Reskiawan A Bayraktutan, Ulvi
Published in
Cellular and molecular neurobiology
Stroke continues to be one of the leading causes of mortality and morbidity worldwide. Restoration of cerebral blood flow by recombinant plasminogen activator (rtPA) with or without mechanical thrombectomy is considered the most effective therapy for rescuing brain tissue from ischaemic damage, but this requires advanced facilities and highly skill...
Martínez-Tapia, Ricardo J Chavarría, Anahí Navarro, Luz
Published in
Cellular and molecular neurobiology
Biological rhythms, especially those that last close to 24 h, better known as circadian rhythms, are highly regulated phenomena, maintained throughout evolution in various organisms which allow organisms to predict, prepare for, and adapt to environmental changes. One of these phenomena that exhibit biological rhythms is the immune response to exte...
Sahab-Negah, Sajad Hajali, Vahid Moradi, Hamid Reza Gorji, Ali
Published in
Cellular and molecular neurobiology
Alzheimer's disease (AD) is described as cognitive and memory impairments with a sex-related epidemiological profile, affecting two times more women than men. There is emerging evidence that alternations in the hippocampal neurogenesis occur at the early stage of AD. Therapies that may effectively slow, stop, or regenerate the dying neurons in AD a...
Teixeira, Bianca Luise Amarante-Silva, Diego Visoni, Silvia Beatriz Garcez, Ricardo Castilho Trentin, Andrea Gonçalves
Published in
Cellular and molecular neurobiology
Neural crest cells (NCCs) comprise a population of multipotent progenitors and stem cells at the origin of the peripheral nervous system (PNS) and melanocytes of skin, which are profoundly influenced by microenvironmental factors, among which is basic fibroblast growth factor 2 (FGF2). In this work, we further investigated the role of this growth f...
Amtul, Zareen Randhawa, Jasmine Najdat, Abdullah N. Hill, David J. Arany, Edith J.
Published in
Cellular and Molecular Neurobiology
Besides other causes, ischemia and Alzheimer’s disease pathology is also linked to decreased cerebral blood flow (CBF). There is little or no consensus about the role of neuroglial cells in maintaining CBF in various neuropathologies. This consensus becomes scarcer when it comes to clinical and experimental cases of comorbid Abeta-amyloid (Aβ) toxi...
Sanyal, Jaya Anirudhan, Athira Banerjee, Tapas Kumar Guha, Gautam Ramakrishnan Veerabathiran, Murugesan, Ram Ahmed, S S J Shiek Rao, Vadlamudi Raghavendra
Published in
Cellular and molecular neurobiology
Besides clinical and imaging techniques, there is a lack of molecular makers for the diagnosis of Parkinson's disease (PD). There is an immense need to develop biomarkers associated with the phenotypes which may be valuable for individualized treatment. Single-nucleotide polymorphisms (PARK2: Ser167Asn (G>A) and Val380Leu (G>C); PARK7: IVS4 + 46G>A...
Perrone, Benedetta La Cognata, Valentina Sprovieri, Teresa Ungaro, Carmine Conforti, Francesca Luisa Andò, Sebastiano Cavallaro, Sebastiano
Published in
Cellular and molecular neurobiology
Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), Parkinson's, Alzheimer's, and Huntington's disease affect a rapidly increasing population worldwide. Although common pathogenic mechanisms have been identified (e.g., protein aggregation or dysfunction, immune response alteration and axonal degen...
Du, Hexi Chen, Xianguo Zhang, Li Liu, Yi Zhan, Changsheng Chen, Jing Wang, Hui Yu, Ziqiang Liang, Chaozhao
Published in
Cellular and molecular neurobiology
Patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) commonly experience learning and memory decline and the underlying pathogenesis remains unclear. Therefore, we aimed to study the effects of CP/CPPS on cognitive function by using a mouse model of experimental autoimmune prostatitis (EAP). Non-obese diabetic mice were immunize...
