Bagwe, Pritam V Deshpande, Radni D Juhasz, Gabor Sathaye, Sadhana Joshi, Shreerang V
Published in
Cellular and molecular neurobiology
STEP (STriatal-Enriched Protein Tyrosine Phosphatase) is a brain-specific phosphatase that plays an important role in controlling signaling molecules involved in neuronal activity and synaptic development. The striatum is the main location of the STEP enzyme. An imbalance in STEP61 activity is a risk factor for Alzheimer's disease (AD). It can cont...
Kulkarni, Prakash G Balasubramanian, Nagalakshmi Manjrekar, Ritika Banerjee, Tanushree Sakharkar, Amul
Published in
Cellular and molecular neurobiology
Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain. However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown. Mitofusin 2 (Mfn2) is a critical component of tethering complexes in mitochondria-associated membranes (MAMs) and thereby plays a pivotal role in mitochondrial functi...
Cheng, Yupei Wu, Bangqi Huang, Jingjie Chen, Yameng
Published in
Cellular and molecular neurobiology
Central Post-Stroke Pain (CPSP) is a primary sequelae of stroke that can develop in the body part corresponding to the cerebrovascular lesion after stroke, most typically after ischemic stroke but also after hemorrhagic stroke. The pathogenesis of CPSP is currently unknown, and research into its mechanism is ongoing. To summarize current research o...
Yadav, Sanjeev Kumar Jauhari, Abhishek Singh, Nishant Pandey, Anuj Sarkar, Sana Pandey, Shweta Garg, Ravindra K Parmar, Devendra Yadav, Sanjay
Published in
Cellular and molecular neurobiology
Parkinson's disease (PD) is a neurodegenerative disorder caused by the selective destruction of dopaminergic neurons (DA-nergic). Clinically, PD is diagnosed based on developing signs and symptoms. A neurological and physical examination and sometimes medical and family history also help in the diagnosis of PD. However, most of these features are v...
Bisoyi, Padmini Ratna, Deshdeepak Kumar, Gaurav Mallick, Birendra Nath Goswami, Shyamal K
Published in
Cellular and molecular neurobiology
Scaffold proteins Striatin and SG2NA assemble kinases and phosphatases into the signalling complexes called STRIPAK. Dysfunctional STRIPAKs cause cancer, cerebral cavernous malformations, etc. DJ-1, a sensor for oxidative stress, has long been associated with the Parkinson's disease, cancer, and immune disorders. SG2NA interacts with DJ-1 and Akt p...
Brugmans, Aliska K Walter, Carolin Moreno, Natalia Göbel, Carolin Holdhof, Dörthe de Faria, Flavia W Hotfilder, Marc Jeising, Daniela Frühwald, Michael C Skryabin, Boris V
...
Published in
Cellular and molecular neurobiology
The BAF (BRG1/BRM-associated factor) chromatin remodelling complex is essential for the regulation of DNA accessibility and gene expression during neuronal differentiation. Mutations of its core subunit SMARCB1 result in a broad spectrum of pathologies, including aggressive rhabdoid tumours or neurodevelopmental disorders. Other mouse models have a...
Sun, Yu-Ying Wang, Zhun Huang, Han-Chang
Published in
Cellular and molecular neurobiology
The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence indicated that ApoE4 contributes to AD through influencing β-amyloid (Aβ) deposition and clearance. However, the molecular mechanisms of ApoE4 involved in AD pathogenesis remains...
Bell-Simons, M Buchholz, S Klimek, J Zempel, H
Published in
Cellular and molecular neurobiology
The microtubule-associated protein Tau is highly enriched in axons of brain neurons where it regulates axonal outgrowth, plasticity, and transport. Efficient axonal Tau sorting is critical since somatodendritic Tau missorting is a major hallmark of Alzheimer's disease and other tauopathies. However, the molecular mechanisms of axonal Tau sorting ar...
Kabirova, M Reichenstein, M Borovok, N Sheinin, A Gorobets, D Michaelevski, I
Published in
Cellular and molecular neurobiology
Abelson non-receptor tyrosine kinases (Abl1 and Abl2) are established cellular signaling proteins, implicated in cytoskeletal reorganization essential for modulation of cell morphology and motility. During development of the central nervous system, Abl kinases play fundamental roles in neurulation and neurite outgrowth, relaying information from ax...
Mohammadshirazi, Atiyeh Apicella, Rosamaria Zylberberg, Benjamín A Mazzone, Graciela L Taccola, Giuliano
Published in
Cellular and molecular neurobiology
Several spinal motor output and essential rhythmic behaviors are controlled by supraspinal structures, although their contribution to neuronal networks for respiration and locomotion at birth still requires better characterization. As preparations of isolated brainstem and spinal networks only focus on local circuitry, we introduced the in vitro ce...
