Sánchez-Temprano, Agustín Relova, José Luis Camiña, Jesús P Pazos, Yolanda
Published in
Cellular and molecular neurobiology
Targeting apoptosis in the ischemic penumbra is a rational therapeutic approach for restricting cerebral infarct volume after clinical stroke. The present work explored the capability of the obestatin peptide, as a novel approach to inhibit apoptotic signaling cascades on PC12 cells. According to the results, obestatin treatment significantly reduc...
Kadir, Rais Reskiawan A Alwjwaj, Mansour Bayraktutan, Ulvi
Published in
Cellular and molecular neurobiology
Stroke continues to be the third-leading cause of death and disability worldwide. The limited availability of diagnostic tools approved therapeutics and biomarkers that help monitor disease progression or predict future events remain as the major challenges in the field of stroke medicine. Hence, attempts to discover safe and efficacious therapeuti...
Ratliff, Whitney A Saykally, Jessica N Keeley, Kristen L Driscoll, David C Murray, Kathleen E Okuka, Maja Mervis, Ronald F Delic, Vedad Citron, Bruce A
Published in
Cellular and molecular neurobiology
Mild traumatic brain injuries can have long-term consequences that interfere with the life of the patient and impose a burden on our health care system. Oxidative stress has been identified as a contributing factor for the progression of neurodegeneration following TBI. A major source of oxidative stress for many veterans is cigarette smoking and s...
Chen, Xiaogang Zhang, Lin Hua, Fu Zhuang, Yu Liu, Huan Wang, Shouguo
Published in
Cellular and molecular neurobiology
Studies have found that molecular targets that regulate tissue development are also involved in regulating tissue regeneration. Erythropoietin-producing hepatocyte A4 (EphA4) not only plays a guiding role in neurite outgrowth during the development of the central nervous system (CNS) but also induces injured axon retraction and inhibits axon regene...
Singh, Sanjiv Gautam, Upendr Manvi, F V
Published in
Cellular and molecular neurobiology
Extensive applications of ZnO NPs (zinc oxide nanoparticles) in daily life have created concern about their biotoxicity. Zinc oxide nanoparticles induce oxidative stress, inflammation, and apoptosis in neurons. Edaravone applies antioxidant agent and anti-inflammatory impacts in the different cells, as evaluated in both in vitro and in vivo experim...
Thapak, Pavan Khare, Pragyanshu Bishnoi, Mahendra Sharma, Shyam Sunder
Published in
Cellular and molecular neurobiology
β-Amyloid (Aβ) peptide is a characteristic feature of Alzheimer's disease (AD) and accumulation of Aβ is associated with loss of synaptic plasticity and neuronal cell death. Aggregation of Aβ initiates numerous molecular signalling pathways leading to oxidative stress, mitochondrial dysfunction as well as an imbalance of calcium ion influx homeosta...
Raeisossadati, Reza Ferrari, Merari F R
Published in
Cellular and molecular neurobiology
Organelles juxtaposition has been detected for decades, although only recently gained importance due to a pivotal role in the regulation of cellular processes dependent on membrane contact sites. Endoplasmic reticulum (ER) and mitochondria interaction is a prime example of organelles contact sites. Mitochondria-associated membranes (MAM) are propos...
Morisaki, Yudai Nakagawa, Ichiro Ogawa, Yoichi Yokoyama, Shohei Furuta, Takanori Saito, Yasuhiko Nakase, Hiroyuki
Published in
Cellular and molecular neurobiology
Ischemic postconditioning (PostC) is known to reduce cerebral ischemia/reperfusion (I/R) injury; however, whether the opening of mitochondrial ATP-dependent potassium (mito-KATP) channels and mitochondrial permeability transition pore (mPTP) cause the depolarization of the mitochondrial membrane that remains unknown. We examined the involvement of ...
Khodagholi, Fariba Maleki, Ali Motamedi, Fereshteh Mousavi, Maryam Alsadat Rafiei, Shahrbanoo Moslemi, Mehdi
Published in
Cellular and molecular neurobiology
Huntington disease (HD) is a progressive neurological disorder with dominant motor symptoms. It also has psychiatric manifestations, like anxiety and depression, that can emerge themselves before motor symptoms and impose a major burden on patients. Oxytocin (OXT) is a newly emerged treatment for disorders like autism and schizophrenia and recently...
Cao, Hui Seto, Sai Wang Bhuyan, Deep Jyoti Chan, Hoi Huen Song, Wenting
Published in
Cellular and molecular neurobiology
Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased ...
